A5010479640- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Psoriasis: Treatment and Pathogenesis
- Health Systems, Economic Evaluations, Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Axon Guidance and Neuronal Signaling
- Immunodeficiency and Autoimmune Disorders
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Whipple's Disease and Interleukins
- Functional Brain Connectivity Studies
- Dermatology and Skin Diseases
- Galectins and Cancer Biology
- HER2/EGFR in Cancer Research
- Advanced Proteomics Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Kruppel-like factors research
- Neurological Disorders and Treatments
- Machine Learning in Healthcare
- Metabolomics and Mass Spectrometry Studies
- Acupuncture Treatment Research Studies
- Hippo pathway signaling and YAP/TAZ
Eisai (United States)
2023-2024
XinHua Hospital
2024
Shanghai Jiao Tong University
2024
C2N Diagnostics (United States)
2010-2022
Centre Hospitalier de l’Université de Montréal
2013-2022
Hainan General Hospital
2020
Chinese PLA General Hospital
2020
Anhui Medical University
2019
Université de Montréal
2010-2016
Hôpital Notre-Dame
2010-2013
Abstract Background The development of blood-based biomarker tests that are accurate and robust for Alzheimer’s disease (AD) pathology have the potential to aid clinical diagnosis facilitate enrollment in AD drug trials. We developed a high-resolution mass spectrometry (MS)-based test quantifies plasma Aβ42 Aβ40 concentrations identifies ApoE proteotype. evaluated robustness, performance, commercial viability this MS assay distinguishing brain amyloid status. Methods used novel analyze 414...
<h3>Importance</h3> The diagnostic evaluation for Alzheimer disease may be improved by a blood-based test identifying presence of brain amyloid plaque pathology. <h3>Objective</h3> To determine the clinical performance associated with algorithm incorporating plasma amyloid-β (Aβ) 42:40 ratio, patient age, and apoE proteotype to identify status. <h3>Design, Setting, Participants</h3> This cohort study includes analysis from 2 independent cross-sectional studies: discovery Plasma Test...
It has been suggested that IL-17RC forms a complex with IL-17RA to mediate the functions of IL-17A and IL-17F homodimers as well IL-17A/F heterodimers. is still unclear whether absolutely required for signaling IL-17 cytokines in vivo. By using Il-17rc-deficient mice, we show essential IL-17A, IL-17F, both vitro does not preassociate on cell surface; rather can induce formation an complex. This process dependent intracellular similar expression fibroblast growth factor genes IL-17Rs (SEFIR)...
Tau neurofibrillary tangles are found in the brains of patients suffering from Alzheimer's disease and other tauopathies. The progressive spreading tau pathology one brain region to next is believed be caused by extracellular transsynaptic transmission misfolded between neurons. Preclinical studies have shown that antibodies against can prevent this transfer cells. Thus, potential stop or slow progression observed human To test hypothesis, a humanized anti-tau antibody (ABBV-8E12) was...
There is an unmet need for accessible, less invasive, cost-effective method to facilitate clinical trial enrollment and aid in Alzheimer's disease (AD) diagnosis. APOE genotype affects the clearance deposition of amyloid-beta (Aβ) with APOE4 carriers having increased risk while APOE2 alleles appear be protective. Lower plasma Aβ42/40 correlates brain amyloidosis. In response, C2N has developed PrecivityAD™ test; LC-MS/MS assays Aβ isoform quantitation qualitative isoform-specific...
Administration of an anti-tau antibody to transgenic mice expressing human tau and patients with tauopathy increased the concentration in plasma.
Cerebrospinal fluid (CSF) is a potential source of biomarkers for many disorders the central nervous system, including Alzheimer disease (AD). Prior to comparing CSF samples between individuals identify patterns disease-associated proteins, it important examine variation within over short period time so that one can better interpret changes in as well given individual longer span. In this study, we analyzed 12 samples, composed pairs from six individuals, obtained 2 weeks apart....
Abstract Diagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood‐based biomarkers (BBMs) for AD holds promise enabling early detection pathology and timely intervention. However, several critical considerations, such as the lack consistent guidelines assessing cognition, limited understanding BBM test characteristics, insufficient evidence on performance across diverse...
Abstract Armadillo repeat containing 5 (ARMC5) is a cytosolic protein with no enzymatic activities. Little known about its function and mechanisms of action, except that gene mutations are associated risks primary macronodular adrenal gland hyperplasia. Here we map Armc5 expression by in situ hybridization, generate knockout mice, which small body size. mice have compromised T-cell proliferation differentiation into Th1 Th17 cells, increased apoptosis, reduced severity experimental...
Abstract ARMC5 is implicated in several pathological conditions, but its function remains unknown. We have previously identified CUL3 and RPB1 (the largest subunit of RNA polymerase II (Pol II) as potential ARMC5-interacting proteins. Here, we show that ARMC5, RBX1 form an active E3 ligase complex specific for RPB1. CUL3, formed Armc5 deletion caused a significant reduction ubiquitination increase accumulation RPB1, hence enlarged Pol pool normal tissues organs. The compromised degradation...
The features and functions of prostatic neuroendocrine (NE) cells remain ill-defined. Neuroendocrine differentiation (NED) in adenocarcinoma the human prostate (CaP) is associated with more aggressive disease, but underlying mediators are poorly understood. We examined these issues transgenic mice that utilize regulatory elements from cryptdin-2 gene (Defcr2) to express simian virus 40 large T antigen (TAg) NE cells. CR2-TAg develop intraepithelial neoplasia at 8 weeks age, 1 week after...
The pathology of Alzheimer's disease (AD) begins years prior to clinical diagnosis. development antecedent biomarkers that indicate the presence AD and predict risk for decline in both cognitively normal mildly impaired individuals will be useful as effective therapies are developed. While cerebrospinal fluid (CSF) markers such amyloid-β (Aβ) 42 tau useful, additional needed. To identify new markers, we utilized 2-D difference gel electrophoresis (2-D DIGE) individual CSF samples from...
We have previously characterized a transgenic mouse model (CR2-TAg) of metastatic prostate cancer arising in the neuroendocrine (NE) cell lineage. Biomarkers NE differentiation this are expressed conventional adenocarcinoma with features. To further characterize pathways that control proliferation, differentiation, and survival, we established (PNEC) lines from CR2-TAg tumors metastases. GeneChip analyses harvested at different passages, as xenografted tumors, indicated PNECs express...