A5026375574- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Renal function and acid-base balance
- Toxin Mechanisms and Immunotoxins
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
- Bone health and treatments
- Intensive Care Unit Cognitive Disorders
- Medicinal Plant Pharmacodynamics Research
- Phytochemistry and Biological Activities
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Sepsis Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Galectins and Cancer Biology
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Neuropeptides and Animal Physiology
- COVID-19 Clinical Research Studies
- Traditional Chinese Medicine Analysis
- Magnesium in Health and Disease
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022-2024
Guangzhou University of Chinese Medicine
2020-2022
Rheumatoid arthritis (RA) is an autoimmune disease of knee joints involving pain and inflammation. Rhoifolin a plant flavonoid known to have antioxidant anti-inflammatory properties. This study was taken identify the effect rhoifolin on complete Freund's adjuvant (CFA)-induced in rat model. Treatment with (10 20 mg/kg) showed significant improvement overall health parameters such as paw edema weight loss. morphological corroborated findings gross changes observed histopathological analysis....
Rheumatoid arthritis (RA) causes serious disability and productivity loss, there is an urgent need for appropriate biomarkers diagnosis, treatment assessment, prognosis evaluation. To identify serum markers of RA, we performed mass spectrometry (MS)-based proteomics, obtained 24 important in normal RA patient samples using a random forest machine learning model 11 protein–protein interaction (PPI) network topological analysis methods. Markers were reanalyzed additional proteomics datasets,...
Yishen Tongbi decoction (YSTB) which is an herbal formula, has been used for the treatment of rheumatoid arthritis (RA) more than ten years with a better curative effect. Methotrexate (MTX) effective anchoring agent to treat arthritis. There were, however, no head-to-head comparative randomized controlled trials comparing traditional Chinese medicine (TCM) MTX, Therefore, we performed this double-blind, double-model, trial efficacy and safety YSTB MTX in active RA 24 weeks. Patients who met...
Rheumatoid arthritis (RA) is one of the most prevalent inflammatory worldwide. However, genes and pathways associated with macrophages from synovial fluids in RA patients still remain unclear. This study aims to screen verify differentially expressed (DEGs) related identifying candidate rheumatoid by bioinformatics analysis.We searched Gene Expression Omnibus (GEO) database, GSE97779 GSE10500 expression profiling multiple microarray dataset were selected conduct a systematic analysis....
Objectives Diet has been shown to be associated with rheumatoid arthritis (RA), and magnesium inhibit inflammatory responses, but research on the relationship between dietary RA is limited controversial. In this study, we aimed explore non-linear intake in US women. Design Cross-sectional survey. Setting National Health Nutrition Examination Survey (NHANES). Primary secondary outcome measures Non-linear prevalence of RA. Participants A total 13 324 women aged 18–80 years (RA n=12 306, non-RA...
Introduction: Rheumatoid arthritis (RA) is a globally challenging and refractory autoimmune disease, constituting serious menace to human health. RA characterized by recurrent pain difficult resolve, necessitating prolonged medication for control. Yishen Tongbi decoction traditional Chinese herbal compound prescribed treating RA. We have completed 3-year RCT study that confirmed the clinical efficacy of Notably, we observed faster remission rate compared MTX week 4 treatment. In our...
Rheumatoid arthritis (RA) is a chronic autoimmune disease. Strong evidence supports that excessive activation of B cells plays critical role in the pathogenesis RA. Fc gamma receptor b (FcγRIIb) cell inhibitory and inhibits BCR (B receptor) signalling part by selectively dephosphorylating CD19 which considered co-receptor for essential activation. Our previous study demonstrated FcγRIIb I232T polymorphism presented strong genetic link to RA may lead cells. Therefore, novel therapeutic...
ABSTRACT Background This study aimed to investigate the linear and nonlinear relationships between ionized calcium levels 28-day mortality in patients with sepsis intensive care unit (ICU) provide clinicians a direction for laboratory index testing basis supplementation program. Methods The data of were extracted from Medical Information Mart Intensive Care (MIMIC-IV) database, iCa served as exposure variable, outcome variable. relationship was investigated using multivariate binary logistic...
Regulatory T (Treg) cells are important immune that regulated by adaptive immunity in the composition of Treg-cell subsets and T-cell receptors (TCRs). Treg related to most autoimmune diseases, such as rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), RA is typically attributed kidney deficiency (KD) associated with immunosenescence causes dysfunction impaired function cells. So far, however, no mechanism KD repertoires has been identified RA.Flow cytometry high-throughput...
Background: Dihydroarteannuin (DHA), which is extracted from the traditional Chinese herb Artemisia annua L , exhibits potent immunosuppressive activity in rheumatoid arthritis (RA). Strong evidence indicates that B cells act as an essential factor pathogenesis of RA, but research on function DHA regulating limited. Objective: To investigate modulatory effects joint destruction, proinflammatory cytokine production, activation, apoptosis and proliferation to explore possible associated...