A5037319695- Nanoparticle-Based Drug Delivery
- Economic and Financial Impacts of Cancer
- Prostate Cancer Treatment and Research
- Cancer Mechanisms and Therapy
- Hormonal and reproductive studies
- COVID-19 and healthcare impacts
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Natural product bioactivities and synthesis
- Molecular Biology Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Alzheimer's disease research and treatments
- Autoimmune and Inflammatory Disorders Research
- Occupational Health and Safety Research
- Histone Deacetylase Inhibitors Research
- Natural Compounds in Disease Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Plant-derived Lignans Synthesis and Bioactivity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neonatal and Maternal Infections
- Systemic Lupus Erythematosus Research
- Ferroptosis and cancer prognosis
- Infant Health and Development
- Protease and Inhibitor Mechanisms
Liaoning University of Traditional Chinese Medicine
2023-2025
Shenyang Pharmaceutical University
2024-2025
Target (United States)
2025
Macau University of Science and Technology
2025
Affiliated Zhongshan Hospital of Dalian University
2025
Dalian Medical University
2022-2024
Second Affiliated Hospital of Dalian Medical University
2022-2024
Huazhong University of Science and Technology
2022
Zhejiang Cancer Hospital
2009-2020
Novogene Bioinformatics Institute
2020
Background: Ovarian cancer is difficult to detect in its early stages, and it has a high potential for invasion metastasis, along with rate of recurrence. These factors contribute the poor prognosis reduced survival times patients this disease. The effectiveness conventional chemoradiotherapy remains limited. Nano-particles, as novel drug delivery system, have significant improving therapeutic efficacy overcoming these challenges. Methods: According expression level matrix...
Objective: Schisandrin B (Sch B) is a bioactive dibenzocyclooctadiene derizative that prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated Sch has neuroprotective action by reducing oxidative stress and effectively preventing inflammation. It follows potential treatment for Alzheimer's disease (AD). However, drug's solubility, bioavailability, lower permeability blood–brain barrier (BBB) can all reduce its efficacy during therapy process. Therefore, this study...
Rheumatoid arthritis (RA) is an autoimmune disease whose pathophysiology closely related to inflammation-associated cells and the microenvironment of inflamed joints. This study aimed develop dual-targeted, reactive oxygen species (ROS)/pH dual-responsive, size-shrinkable intelligent micelles targeting M1 macrophages fibroblast-like synoviocytes (FLSs) enhance drug efficacy safety. These were surface-modified with PEG5000 prolong their circulation time in bloodstream hide molecules. The...
Low immune infiltration is closely associated with poor clinical results and an unfavorable response to therapy in triple-negative breast cancer (TNBC). T-cell exhaustion (TEX) a significant risk factor for tumor immunosuppression invasion. Although improving TEX enhancing effector function are promising strategies strengthening immunotherapy, their role the pathogenesis of TNBC remains unclear. This study's objective was develop prognostic model based on exhausted CD8+ (CD8+ Tex)-related...
Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for serious infections in humans. The overuse of antibiotics has led to the evolution resistance genes bacteria. This study aimed develop pH-responsive micelle, loaded with therapy drugs and modified antimicrobial peptides, treat drug-resistant bacterial at varying depths. micelles containing azithromycin curcumin, Magainin II, were prepared using thin-film dispersion method. physicochemical properties...
Introduction: Ovarian cancer is a malignant tumor that arises in the female reproductive system and associated with very high mortality rate. This primarily due to highly invasive nature of metastasis recurrence. Transforming immune environment from an immunosuppressive state anti-tumor through phenotypic transformation tumor-associated macrophages crucial for inhibiting growth, metastasis, recurrence ovarian cancer. Methods: A polymer micelle (RC-PH-Ms) containing paclitaxel (PTX) honokiol...
This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance. Proteomic analysis compared differential protein expression between CRC patients with (CRLM) those without (CRNLM). Bioinformatics survival analyses identified key proteins validated them using the TCGA database for significance. Clinical pathological data, along tissue samples from our center, were used create microarrays immunohistochemistry....
LY01005 (Goserelin acetate sustained-release microsphere injection) is a modified gonadotropin-releasing hormone (GnRH) agonist injected monthly. This phase III trial study aimed to evaluated the efficacy and safety of in Chinese patients with prostate cancer.
Prostate cancer (PCa) is the second most prevalent malignancy and fifth cause of cancer-related deaths in men. A crucial challenge identifying population at risk rapid progression from hormone-sensitive prostate (HSPC) to lethal castration-resistant (CRPC). We collected 78 HSPC biopsies measured their proteomes using pressure cycling technology a pulsed data-independent acquisition pipeline. quantified 7355 proteins these biopsies. total 251 showed differential expression between patients...
Abstract Bladder cancer (BC) is a prevalent urological tumor with high recurrence rates, requiring long‐term monitoring. Although cystoscopy the primary diagnostic method, its invasiveness and cost hinder routine screening follow‐up. This study aimed to develop novel tool utilizing newly developed on‐chip heating dPCR platform, which features integrated rapid temperature control capabilities, for non‐invasive BC detection. The platform improved by integrating multi‐color detection system,...
Abstract Background: Due to the increased risk of viral infection and severe shortage medical resources during pandemic COVID-19, most hospitals in epidemic areas significantly reduced non-emergency admissions services, if not closed. As a result, it has been difficult treat cancer patients on time, which adversely affects their prognosis. To address this problem, centers must develop strategic plan manage both inpatients outpatients pandemic, provide them with necessary treatment, at same...