A5073810472- CRISPR and Genetic Engineering
- Venous Thromboembolism Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced biosensing and bioanalysis techniques
- Sperm and Testicular Function
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Surgical Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Innovation and Socioeconomic Development
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Maternal and fetal healthcare
- Hippo pathway signaling and YAP/TAZ
- Bioactive Natural Diterpenoids Research
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Protein Kinase Regulation and GTPase Signaling
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Hemodynamic Monitoring and Therapy
- Immune cells in cancer
- Cancer Research and Treatments
Affiliated Zhongshan Hospital of Dalian University
2025
Karolinska Institutet
2024
Xiamen University
2024
Svenska Örtmedicinska Institute
2024
Helsinki University Hospital
2023
University of Helsinki
2021-2023
Zhujiang Hospital
2018-2019
Southern Medical University
2018-2019
Glaucocalyxin A (GLA), a major component isolated from Rabdosia japonica, has been proven to show anti-bacterial and anti-tumor biological characteristics according previous studies.However, its potential effect on bladder cancer remains unknown.The present research aims investigate the underlying mechanism in treating vivo vitro.Cell proliferation was analyzed by CCK-8 assay colony formation.Flow cytometry used measure cell cycle distribution apoptosis.The expressions of apoptosis-related...
This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance. Proteomic analysis compared differential protein expression between CRC patients with (CRLM) those without (CRNLM). Bioinformatics survival analyses identified key proteins validated them using the TCGA database for significance. Clinical pathological data, along tissue samples from our center, were used create microarrays immunohistochemistry....
Bufalin, one of the active ingredients Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, role bufalin in renal cell carcinoma (RCC) remains unclear. In present study, it was demonstrated that inhibited proliferation, blocked cycle G2/M phase, and reduced metastasis human RCC ACHN cells via upregulation p21waf/cip1 E‑cadherin downregulation cyclin dependent kinase 1, B1, N‑cadherin, hypoxia‑inducible factor‑1α (HIF‑1α). Further mechanistic...
Programmed cell death protein 1 (PD-1) blockade is a promising therapeutic strategy against prostate cancer.Nitroxoline has been found to have effective anticancer properties in several cancer types.We investigated the efficacy of combination therapy involving nitroxoline and PD-1 mouse model.In our vitro analysis, we that inhibited viability proliferation line RM9-Luc-PSA.Additionally, downregulated expressions phospho-PI3 kinase, phospho-Akt (Thr308), (Ser473), phospho-GSK-3β, Bcl-2,...
Precursor (pre)-CRISPR RNA (crRNA) processing can occur in both the repeat and spacer regions, leading to removal of specific segments from sequences, thereby facilitating crRNA maturation. The pre-crRNA by Cas effector ribonuclease has been observed CRISPR-Cas9 CRISPR-Cas12a systems. However, no evidence cleavage any enzyme reported these In this study, we demonstrate that DNA target binding triggers efficient spacers type II V effectors such as Cas12a, Cas12b, Cas12i, Cas12j Cas9. We show...
Abstract Introduction: Subsets of cancer-associated fibroblasts (CAFs) in colorectal cancer remain poorly characterized preventing their use as biomarkers and drug targets. Results: Integrated scRNA seq profiling multiplex staining identified four human CAF subsets These were A1 (PDGFRA+/FAP-/TF), PDGFRAhighA2 (PDGFRA+/FAP+/TF-), PDGFRAlowA2 (PDGFRA-/FAP+/TF-) A3 (PDGFRA+/FAP-/TF+) (TF: Tissue Factor).Spatial analyses spatial associations indicative specific functional interactions...
Abstract Introduction: Properties of tumor angiogenesis impact on growth and composition the microenvironment. Tumor vessels are composed pericytes other mural cells. Detailed characterization cellular microvasculature can suggest functional vessel case properties relevant for outcome, response to treatment immune surveillance. Results: Based single cell RNA-seq from three human stage II/III colon cancers pilot in-situ multi-antibody staining six tumors two main clusters perivascular cells...
To determine the role of outer dense fiber (ODF) in multiple morphological abnormalities sperm flagella Akap4 gene defect mice. Methods: knock-out (KO) mouse model was established by using editing technology. Akap4-KO male mice were identified genotype. Seven sexually mature served as an experimental group, and 7 wild-type (WT) a control group. The changes body weight testicular measured. Computer aided analysis (CASA) used to detect motility. Sperm morphology detected modified Periodic...