A5100386369- Animal Virus Infections Studies
- Urinary Bladder and Prostate Research
- Viral gastroenteritis research and epidemiology
- Prostate Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Analytical Chemistry and Chromatography
- Hormonal and reproductive studies
- Yeasts and Rust Fungi Studies
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Plant Physiology and Cultivation Studies
- Adenosine and Purinergic Signaling
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Plant Pathogens and Fungal Diseases
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Cardiac Fibrosis and Remodeling
- Simulation-Based Education in Healthcare
- Xenotransplantation and immune response
- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatment
- Ziziphus Jujuba Studies and Applications
- Innovative Educational Techniques
China Pharmaceutical University
2020-2025
Jiangnan University
2023
Zhujiang Hospital
2014-2023
Southern Medical University
2013-2023
Chinese Academy of Agricultural Sciences
2018-2023
Institute of Special Animal and Plant Sciences
2022-2023
Qingdao Agricultural University
2016-2022
Jiangsu University of Science and Technology
2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020
Chongqing Medical University
2020
Abstract Background and Aims Macrophage-derived foam cells play a causal role during the pathogenesis of atherosclerosis. P2Y6 receptor (P2Y6R) highly expressed has been considered as disease-causing factor in atherogenesis, but detailed mechanism remains unknown. This study aims to explore P2Y6R regulation macrophage foaming, its downstream pathways. Furthermore, present sought find potent antagonist investigate feasibility P2Y6R-targeting therapy for Methods The expression was examined...
More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR China 2002, there is still no reoccurrence, but evolution recombination this region are unknown. Therefore, surveillance on prevalence virus variation HCoVs circulation conducted. A total 3298 nasopharyngeal swabs samples were collected from cross-border children (<6 years, crossing border between Southern SAR) showing symptoms respiratory tract infection, such as fever (body...
Guangdong Province is the area most seriously affected by dengue fever in China. In this study, we describe spatial distribution of from 2001 to 2006 with objective informing priority areas for public health planning and resource allocation. Annualized incidence at a county level was calculated mapped show crude incidence, excess hazard, smoothed incidence. Geographic information system–based scan statistics conducted detect pattern level. Spatial cluster analyses suggested that counties...
Prostate smooth muscle tone and hyperplastic growth are involved in the pathophysiology treatment of male lower urinary tract symptoms (LUTS). Available drugs characterized by limited efficacy. Patients' adherence is particularly low to combination therapies 5α-reductase inhibitors α1-adrenoceptor antagonists, which supposed target contraction simultaneously. Consequently, molecular etiology benign prostatic hyperplasia (BPH) new compounds interfering with or prostate high interest. Here, we...
Bufalin, one of the active ingredients Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, role bufalin in renal cell carcinoma (RCC) remains unclear. In present study, it was demonstrated that inhibited proliferation, blocked cycle G2/M phase, and reduced metastasis human RCC ACHN cells via upregulation p21waf/cip1 E‑cadherin downregulation cyclin dependent kinase 1, B1, N‑cadherin, hypoxia‑inducible factor‑1α (HIF‑1α). Further mechanistic...
TRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported be a tumor suppressor or have oncogenic function in many cancer types. The aim of this study was investigate whether downregulation by small interfering ribonucleic acid (siRNA) could inhibit cell proliferation and invasion increase chemosensitivity cisplatin human lung squamous NCI-H520 cells vitro.We transformed siRNA into cells. Real time reverse transcriptase polymerase chain reaction Western blotting...
P2Y14 nucleotide receptor is a Gi protein-coupled receptor, which widely involved in physiological and pathologic events. Although several P2Y14R antagonists have been developed thus far, few successfully into therapeutic drug. In this study, on the basis of two homology models, Glide docking-based virtual screening (VS) strategy was employed for finding potent with novel chemical architectures. A total 19 structurally diverse compounds identified by VS drug-like properties testing were set...
Enantioselectivity in environmental behaviour of chiral pesticides has become a subject growing interest.
Apple Glomerella leaf spot (GLS) is a destructive fungal disease that damages apple leaves during the summer in China. Breeding new disease-resistant varieties considered to be best way of controlling GLS. A genetic study resistance was conducted by using four F1 hybrid groups ('Fuji' × 'Golden Delicious', Delicious' 'Fuji', 'Gala' and 'Fuji' 'QF-2') generated from two highly resistant or selections, 'QF-2', susceptible varieties, 'Gala'. The results showed separation ratios plants ones were...
Previous studies have demonstrated that lipopolysaccharide (LPS), as a central toxic factor of gram-negative bacteria, can induce oxidative stress and cellular inflammation to result in the impairment female fertility different organisms. Particularly, it has harmful effects on oocyte quality subsequent embryonic development. However, approach concerning how prevent oocytes from LPS-induced deterioration still remains largely unexplored. We assessed effective influences velvet antler water...
Background and Purpose In benign prostatic hyperplasia, increased prostate smooth muscle tone volume may contribute alone or together to urethral obstruction voiding symptoms. Consequently, it is assumed there a connection between growth in the prostate, but any molecular basis for this poorly understood. Here, we examined effects of Src family kinase (SFK) inhibitors on contraction stromal cells. Experimental Approach SFK inhibitors, AZM475271 PP2, were applied human tissues assess...
The present study aimed to expound the association between XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles risk of coronary artery disease (CAD) ischemic stroke.The genetic makeup XKR6 SNP in 1783 unrelated participants (controls, 643; CAD, 588 stroke, 552) Han Chinese was obtained by Snapshot technology.The genotypic frequencies were disparate CAD (GG, 81.0%; GA/AA, 19.0%) or stroke 81.2%; 18.8%) patients healthy controls 85.7%, 14.3%; P <...
Background: Once prostate cancer developed bone metastasis, the quality of life and prognosis patients are seriously affected as no effective treatment is currently available.It necessary to explore mechanism metastasis new therapeutic targets.Purpose: To find out differentially expressed serum proteins in with analyze expression key tissues, cell lines.So provide a basis for revealing designing targets.Methods: iTRAQ-based proteomics method was used compare differential without...
Epidemiologic studies revealed a context between lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and metabolic syndrome. However, molecular mechanisms underlying this relationship are largely unknown. Prostate enlargement increased prostate smooth muscle tone important factors in the pathophysiology LUTS BPH. In present study, we studied effects hormone ghrelin on rats with experimentally induced BPH, growth cultured stromal cells from human (WPMY-1),...
It has been reported that cholesterol-lowing agents can ameliorate severity of myocarditis. However, the beneficial effect claimed to be independent cholesterol reduction as there is no significant change in plasma level In present study, using experimental autoimmune myocarditis (EAM) rats an animal model, we demonstrated EAM induced elevation and impaired efflux capacity cardiac tissue. Moreover, serum high-density lipoprotein (HDL) content was reduced HDL function associated protein...
The associations between single nucleotide polymorphisms (SNPs) rs2710642 and rs10496099 their effect on the EH domain-binding protein 1 (EHBP1) gene serum lipid profiles remain uncertain. This study was performed to investigate two EHBP1 SNPs in Han Maonan populations, including association, haplotypes, effects levels. Two 564 796 participants were genotyped by high-throughput sequencing, then genotype haplotype distributions of analyzed. Moreover, risk factors levels analyzed using...
Objective . To evaluate the effects of human bone marrow mesenchymal stem cells (hBMSCs) and osteoblasts (hFOB1.19) on PC3 prostate cancer cells. Methods simulate in vivo interaction between bone/bone microenvironments cells, we established cocultures with hBMSC or hFOB1.19 evaluated their proliferation, cell cycle distribution, migration, invasion Quantitative reverse transcription polymerase chain reaction was used to detect CD59 mRNA expression The receptor activator nuclear factor- (NF-)...