A5037278089- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Epigenetics and DNA Methylation
- Urinary Tract Infections Management
- Cancer-related molecular mechanisms research
- Pelvic floor disorders treatments
- Urinary and Genital Oncology Studies
- Cardiac Ischemia and Reperfusion
- Sesquiterpenes and Asteraceae Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Minimally Invasive Surgical Techniques
- Bone health and treatments
- Extracellular vesicles in disease
- Urologic and reproductive health conditions
- Anesthesia and Pain Management
- Cancer-related Molecular Pathways
Zhujiang Hospital
2013-2023
Southern Medical University
2013-2023
Long noncoding RNAs (LncRNAs) are very important in the way that docetaxel resistance (DR) happens prostate cancer (PCa) patients. ImmuneScore and StromalScore were calculated using PCa-related expression data from TCGA ESTIMATE algorithm. We finally found DEGs related to immune system stroma of patients by making profiles StromalScore. The CancerSubtypes algorithm identified prognosis-related PCa subtypes, GSVA assessed their pathway activity. A UniCox regression analysis was used identify...
The management of castration-resistant prostate cancer (CRPC) is challenging, attributable to a lack efficacious therapies. Chemotherapy one the most important treatments for CRPC. Doxorubicin has been extensively used in many different tumors and often combined with other drugs enhance effects reduce toxicity. Costunolide natural sesquiterpene lactone anti-cancer properties. In this study, we first demonstrated that combination costunolide doxorubicin induced apoptosis significantly more...
OBJECTIVES: In men, human prostate cancer (PCa) has become the second most common cancer. miRNAs are short non-coding RNAs that can inhibit target gene mRNAs. Studies have showed alternation of expression in is relevant to pathogenesis tumor. present study, we aimed investigate functions miR-214-5p PCa. MATERIALS AND METHODS: 10 paired tumor tissues and homologous para-tumor were recruited, levels CRMP5 respectively determined by qRT-PCR assay. Luciferase activity analysis was performed...
Background: Castration-resistant prostate cancer (CRPC) is still considered incurable, even though the mechanisms of CRPC had been extensively researched. Studies have demonstrated that exosomes in tumor microenvironment contribute to development and progression. However, role process progression has not yet determined. Methods: Co-culturing exosome treatment assays combined with vitro vivo were performed determine function transformation androgen-dependent (ADPC) cells into...
Cluster of differentiation (CD)24 was originally described as a B lymphocyte marker and has recently received considerable attention in cancer research its overexpression been observed several types carcinoma. The CD24 molecule is glycosyl‑phosphatidylinositol‑linked cell surface protein that appears to be associated with aggressive cancers involving invasion metastasis. However, the expression human bladder clinical significance remains largely unknown no association reported between tumor...
Therapy options for prostate cancer (PCa) typically are centered on docetaxel-based chemotherapy but limited by the effects of multi-drug resistance. Recent advances have illustrated a role contactin-1 (CNTN-1) in tumor chemoresistance, while function and mechanism CNTN-1 resistance docetaxel not yet been elucidated.Docetaxel (Dox)-resistant PCa cell lines PC3 (PC3-DR) DU145 (DU145-DR) were established, short hairpin RNA (shRNA) constructs targeting generated to analyze effect knockdown...
Background: Once prostate cancer developed bone metastasis, the quality of life and prognosis patients are seriously affected as no effective treatment is currently available.It necessary to explore mechanism metastasis new therapeutic targets.Purpose: To find out differentially expressed serum proteins in with analyze expression key tissues, cell lines.So provide a basis for revealing designing targets.Methods: iTRAQ-based proteomics method was used compare differential without...
Background: Prostate cancer (PCa) is a leading cause of cancer-related death in men. Sodium phenylbutyrate (SPB) has shown its potential as an anticancer therapy numerous types. In the present study, we attempted to assess effect SPB against PCa and whether this treatment was associated with regulation survivin. Methods: Two human cell lines, DU145 PC3, were used study. Cell Counting Kit-8 (CCK-8) assay conducted measure proliferation cells incubated SPB. The on apoptosis, colony formation...
To assess the value of clinically relevant data for predicting failure removal urinary catheter within 48 hours after TUERP. Materials and Methods. We retrospectively analyzed medical records 357 patients who underwent TUERP between January 2015 July 2018, all whom stopped bladder irrigation removed operation. According to whether was successful, were classified into 2 groups: Group A successful group B a failure. Univariate analysis performed determine association patients' preoperative...
Objective To discuss the feasibility of percutaneous nephrolithotomy (PCNL) for treating upper urinary calculi under local anesthesia.Methods One thousand three hundred and sixty-three patients who suffered with were treated PCNL, puncture tracts created using anesthesia guided through ultrasound.Of 1363 patients, 475 had complicated renal caluli, 520 kidney pelvic 368 uretere calculi.Results All successfully received PCNL anesthesia.Of five used in two four nine double 25 patents one tract...
Objective To evaluate the safety and efficacy of orthotopic taenia myectomy sigmoid neobladder for elderly patients (≥ 70 years old) with bladder cancer after laparoscopic radical cystectomy.Methods We retrospectively analyzed clinical data 63 cancer,including 52 males 11 females mean age 74 old (ranged 70-87 old),who had accepted cystectomy under general anesthesia from August 2002 to July 2012.The clinic stage in those included T1N0M0 4 cases T2N0M0 59 cases.Results The operative...
To investigate the effect of progressive pre-disconnection urethral mucosal flap during transurethral plasmakinetic enucleation prostate (TUPEP) on early recovery urinary continence.Clinical data patients with benign prostatic hyperplasia (BPH) admitted in Zhujiang Hospital Southern Medical University February and May 2022 were collected. All underwent TUPEP, was performed procedure. The total operation time, postoperative bladder irrigation time catheter indwelling recorded. Urinary...
You have accessJournal of UrologyMale Voiding Dysfunction (BPH & Incontinence) Infection1 Apr 2010V328 COMBINED TRANSVESICAL AND TRANSURETHRAL ENUCLEATION OF THE PROSTATE - A NOVEL TECHNIQUE Pradeep Rao, Mihir Desai, Binshen Chen, Rene Sotelo, and Chunxiao Liu RaoPradeep Rao Mumbai, India More articles by this author , DesaiMihir Desai Los Angeles, CA ChenBinshen Chen Guangzhou, People's Republic China SoteloRene Sotelo Caracas, Venezuela LiuChunxiao View All Author...
Background: Here we present our experience of primary orthotopic taeniamyectomized sigmoid neobladder reconstruction following radical cystectomy/prostatocystectomy due to bladder/prostate rhabdomyosarcoma in children resistant chemotherapy and/or radiotherapy.Methods: Of 52 patients diagnosed with persistent genitourinary rhabdomyosarcoma, 43 boys and six girls underwent prostatocystectomy or cystectomy between August 2003 February 2019. Three did not undergo because positive urethral...
Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma. Approximately 15-20% of RMS cases arise from bladder and prostate (B/P). The optimal treatment strategy for B/P remains unclear.To retrospectively evaluate applicability our procedure performed to treat patients with RMS.This a retrospective analysis single tertiary referral hospital. From August 2003 March 2021, 62 children pathologically diagnosed underwent radical cystectomy orthotopic detaenial sigmoid neobladder...