A5101791392- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Traditional Chinese Medicine Analysis
- HER2/EGFR in Cancer Research
- Flavonoids in Medical Research
- Genetic factors in colorectal cancer
- Polymer composites and self-healing
- Stress Responses and Cortisol
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mesenchymal stem cell research
- Epoxy Resin Curing Processes
- Wnt/β-catenin signaling in development and cancer
- Selenium in Biological Systems
- Effects of Radiation Exposure
- Astronomical and nuclear sciences
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
Luoyang Institute of Science and Technology
2022
University of California, Berkeley
1999-2020
Henan University of Science and Technology
2019-2020
Eli Lilly (United States)
2020
Abstract In earlier studies, the assimilation of selenate by plants appeared to be limited its reduction, a step that is thought mediated ATP sulfurylase. Here, Arabidopsis APS1 gene, encoding plastidic sulfurylase, was constitutively overexpressed in Indian mustard (Brassica juncea). Compared with untransformed plants, sulfurylase activity 2- 2.5-fold higher shoots and roots transgenic seedlings, 1.5- 2-fold but not selenate-supplied mature ATP-sulfurylase-overexpressing (APS) plants. The...
Rheumatoid arthritis (RA) is an autoimmune disease that may be associated with gut microbiota via the aryl hydrocarbon receptor (AhR). Human umbilical mesenchymal stem cells (HUMSCs) have therapeutic potential against RA, but underlying mechanism has not been fully elucidated. The purpose of this study was to explore action HUMSCs in rats collagen-induced (CIA).HUMSCs (1 × 106) were transplanted into each rat CIA. tissue localization and effects ankles assessed. immune status expression...
红色文化的本质是红色基因，红色基因的落地生根就是红色青年。浙江作为中国共产党的发源地，其深厚的历史文化背景为五四精神的传播提供了肥沃土壤。本文首先回顾了五四前夕浙江进步青年力量的形成，分析了其背后的历史、教育和文化因素。接着，重点分析了五四运动期间浙江青年积极参与抗议活动、形成反帝爱国浪潮的过程，以及浙江学生联合会的成立与作用。特别指出，爱国青年们通过创办《浙江新潮》等进步刊物，推动了新思想的传播和社会的觉醒。结论认为，五四精神的核心理念，如爱国主义和科学精神，对当代思想政治教育具有重要意义，能够培养青年学生的社会责任感和创新意识，为实现中华民族的伟大复兴贡献力量。通过挖掘五四精神在浙江的传播，能够为新时代的思政教育提供丰富的素材和实践案例。
Abstract: A method for the simultaneous determination of parecoxib and its metabolite valdecoxib in beagle plasma by UPLC-MS/MS was developed validated. After extracted acetonitrile precipitation, analytes were separated on an Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) using acetonitrile-formic acid as mobile phase gradient mode. The monitored multiple reaction monitoring (MRM) electrospray negative ion mass transfer pairs m/z 368.97→ 119.01 parecoxib, 312.89→ 118.02 valdecoxib,...
Abstract This paper delves to improve the upper‐limit temperature of hydrogenated nitrile rubber (HNBR) through regulation vulcanization process, filler system and cross‐linking additive. The tensile test scanning electron microscope images showed that aging at 180°C significantly accelerated deterioration in property HNBR compared with 150°C aging. results a higher dosage bis(1‐(tert‐butylperoxy)‐1‐methylethyl)‐benzene curing agent reduced compression set without sacrificing its strength....
In our research, a straightforward UPLC-MS/MS method, with diazepam as the internal standard (IS), was proposed and acknowledged to determine concentrations of enasidenib in rat plasma. When preparing sample, we used acetonitrile for protein precipitation. The gradient elution method used, mobile phase 0.1% formic acid. Diazepam IS. We Acquity UPLC BEH C18 column separate Under positive ion electrospray ionization (ESI) source conditions, mass transfer pairs were monitored by multiple...
Chaihu-shugan-san (CHSGS) has been widely used in China to treat depression and gastrointestinal diseases for thousands of years, but little is known about its pharmacokinetic properties. The purpose our study develop a reliable sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method detect five components beagle plasma their after oral administration CHSGS beagles. An Agilent C18 column (2.1 × 150 mm, 3.5 μ m) was separate the analytes, temperature...
Abstract Patients with non-small cell lung cancer (NSCLC) activating epidermal growth factor receptor (EGFR) mutations initially respond to small molecule inhibitors of the EGFR tyrosine kinase such as gefitinib and erlotinib. However, secondary in domain lead acquired resistance these limited clinical efficacy, T790M mutation being most common mechanism more than half patients that experience disease progression. CK-101 (also known RX518) is a novel, irreversible, orally administered...
To explore the relationship between mutant p53 and multidrug resistance in gastric cancer.Mutant (mp53) mp53+sv40Tag were transferred to cancer cell line SGC-7901. The MDR-1 mRNA was examined using RT-PCR, difference chemotherapeutic sensitivity of SGC-7901 cells with compared those controls by MTT method.SGC-7901 showed higher than that other two groups. 5-Fu control (P<0.05), but no (P>0.05). ADM mp53 There CDDP (P>0.05).Mutante genes relates cancer.
A reliable and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of zanubrutinib in plasma beagle dogs. The column used an Acquity BEH C18 (2.1 mm × 50 mm, 1.7 μm), maintained at 40°C with injection volume 2 μl. gradient elution program as follows: 0-1 min, 10-10% A; 1-1.1 10-90% 1.1-2.1 90-90% 2.1-2.2 90-10% 2.2-3.0 A. Mobile phase 0.1% formic acid, B acetonitrile, total analysis time 3 min. performed positive...
Objective Study the computer toxicity prediction technology and predict carcinogenicity of rats from chemical components Chinese materia medica, in order to provide a new method for safety evaluation medica. Methods The Mold2 software (version 2.0.0)was used calculate molecular descriptors 1 532 components. After preliminary screening descriptors, quantitative structure-activity relationship (QSAR)models were built up with Random Forest (RF)for optimum model. From 83 kinds toxic...