A5100381374- Flavonoids in Medical Research
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Gestational Diabetes Research and Management
- Microbial Natural Products and Biosynthesis
- Acute Ischemic Stroke Management
- Lung Cancer Diagnosis and Treatment
- Insect and Pesticide Research
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Gynecological conditions and treatments
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Research Studies
- Chronic Kidney Disease and Diabetes
- Medicinal Plant Pharmacodynamics Research
- Synthesis and Biological Activity
- Obesity and Health Practices
- Ectopic Pregnancy Diagnosis and Management
- Phytoestrogen effects and research
- Uterine Myomas and Treatments
- Synthesis and biological activity
- Pregnancy and preeclampsia studies
- Tea Polyphenols and Effects
- Medicinal plant effects and applications
- MRI in cancer diagnosis
Obstetrics and Gynecology Hospital of Fudan University
2022-2025
Henan University of Technology
2025
La Jolla Bioengineering Institute
2025
South China University of Technology
2025
Affiliated Eye Hospital of Wenzhou Medical College
2023
Wenzhou Medical University
2023
Guangxi Medical University
2023
Central South University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Third Xiangya Hospital
2022
Introduction: Ulcerative colitis (UC) is an inflammatory bowel disease with a high incidence rate and difficult treatment regimen. Recently, significant advances in the of intestinal diseases, particularly UC, have been made use drugs baicalin baicalein, separately or combination. However, therapeutic efficacy mechanism action baicalin, their combination therapy, UC has not fully elucidated. Materials Methods: we constructed rat model that encompassed variety complex factors, including...
Introduction: Diabetic nephropathy (DN) has become an increasing threat to health, and inflammation fibrosis play important roles in its progression. Wogonin, a flavonoid, been proven suppress various diseases, including acute kidney injury. This study aimed at investigating the effect of wogonin on diabetes-induced renal fibrosis. Materials Methods: Streptozotocin (STZ)-induced diabetic mouse models received gavage doses (10, 20, 40 mg/kg) for 12 weeks. Metabolic indices from blood urine...
Introduction: Kidney tubular epithelial injury is one of the key factors in progression diabetic nephropathy (DN). Wogonin a kind flavonoid, which has many pharmacological effects, such as anti-inflammation, anti-oxidation and anti-fibrosis. However, effect wogonin renal cells during DN still unknown. Materials Methods: STZ-induced mice were given doses (10, 20, 40 mg/kg) by intragastric administration for 16 weeks. The metabolic indexes from blood urine pathological damage tubules...
von Willebrand factor (vWF) is a large glycoprotein in circulation system, which senses hydrodynamic force at vascular injuries and then recruits platelets assembling clots. How vWF mechanosenses shear flow for molecular unfolding an important topic. Here, Förster resonance energy transfer (FRET) biosensor was developed to monitor conformation change force. The full-length vWF-based anchored on cell surface, A2 domain flanked with FRET pair. With 293T cells seeded into microfluidic...
von Willebrand factor (vWF) is a large glycoprotein in the circulation system, which senses hydrodynamic force at vascular injuries and then recruits platelets assembling clots. How vWF mechanosenses shear flow for molecular unfolding an important topic. Here, Förster resonance energy transfer (FRET) biosensor was developed to monitor conformation change force. The vWF-based anchored on cell surface, A2 domain flanked with FRET pair. With 293T cells seeded into microfluidic channels, 2.8...
Cardiovascular disease constitutes the leading cause of mortality in patients with chronic kidney (CKD) and end-stage renal disease. Despite increasing recognition a close interplay between dysfunction cardiovascular disease, termed cardiorenal syndrome (CRS), underlying mechanisms CRS remain poorly understood. Here we report development pathological cardiac hypertrophy fibrosis early stage non-uremic CKD. Moderate failure was induced three weeks after unilateral urinary obstruction (UUO)...
VEGFA is one of the most important regulators angiogenesis and plays a crucial role in cancer progression. Recent studies have highlighted relationship between expression renal cell carcinoma occurrence. However, level, gene regulation network, prognostic value, target prediction remain unclear. Therefore, system analysis expression, patients with great theoretical significance as there clinical demand for discovery new treatment targets strategies to further improve efficacy.This study used...
Objectives The relationship between prenatal physical activity (PA) and adverse birth outcomes is still inconclusive. We aimed to investigate the association PA during pregnancy by using data from Guangxi Zhuang cohort (GZBC) in China.Study Design A total of 11,292 mother-infant pairs were included GZBC China. information on status, intensity, adequacy, volume collected. Multivariable linear logistic regression models applied analyze effects weight z-scores (BW z-scores) gestational age risk...
Abstract Background Enrofloxacin is an antibacterial drug with broad-spectrum activity that widely indicated for veterinary use. We aim to develop the clinical applications of against colibacillosis by using neutropenic mice thigh infection model. Results The minimum inhibitory concentration (MIC) distribution 67 isolated E. coli strains ENR was calculated CLSI guidelines. Whereas, MIC 50 value calculation considered as population PD parameter strains. values 15 were found be nearest i.e. ,...
Abstract Chemical investigation of terrestrial and marine streptomycete isolates led to the identification two new natural pigments, namely, 6-hydroxyisatin ( 3 ) 6-hydroxy-5-methoxyisatin 4 ). Additionally, strains delivered numerous known compounds, among them N β -acetyltryptamine, -acetyltyramine, phenylacetamide, -(2-phenethyl)acetamide, 1-acetyl- -carboline, tyrosol, 2′-deoxyadenosine, 2′-deoxythymidine, anthranilic acid, 2′-deoxyuridine, indolyl-3-acetic indolyl-3-carboxylic p...
The correlation between cerebral small vessel disease (CSVD) and the outcomes of acute ischemic stroke (AIS) patients after endovascular therapy (EVT) remains elusive. We aimed to investigate effect combined white matter hyperintensities (WMH) enlarged perivascular spaces (EPVS) as detected in magnetic resonance imaging (MRI) at baseline on clinical with AIS who underwent EVT. that experienced EVT were retrospectively analyzed this single-center study. Using MRIs taken prior EVT, we rated...
Abstract Objective Stroke causes serious physical disability with impaired quality of life (QoL) and heavy burden on health. The goal this study is to explore the QoL typologies their predicting factors in physically disabled stroke survivors machine learning approach. Methods Non‐negative matrix factorization (NMF) was applied clustering 308 rural China based responses short form 36 (SF‐36) assessment life. Principal component analysis (PCA) conducted differentiate subtypes, Boruta...
To explore the effect of Fuke Qianjin Capsules on anti-endometrial fibrosis in intrauterine adhesion(IUA) rats through TGF-β1-PI3 K/Akt signaling pathway. With female SD as object, IUA rat models were established mechanical injury and infection, they randomly divided into normal group, sham operation Bujiale group(0.63 mg·kg~(-1)·d~(-1)), high-dose group(1.008 g·kg~(-1)·d~(-1)), medium-dose group(0.504 low-dose group(0.252 g·kg~(-1)·d~(-1)). The sacrificed 21 days after drug administration,...
To analyze the complex relationship between chemical components and functions of traditional Chinese medicine, this study put forward concept "chemical functiomics" for first time defined connotation significance based on research core hemostatic blood-activating/stasis-resolving herbal drugs, which provided a new direction modern medicine. The Traditional Medicine Systems Pharmacology Database Analysis Platform(TCMSP), Encyclopedia Medicine(ETCM), Natural Product Activity Species...