A5061947040- Bone Metabolism and Diseases
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Phytochemistry and Biological Activities
- Biomarkers in Disease Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
- Antioxidant Activity and Oxidative Stress
- Bone health and osteoporosis research
- Fatty Acid Research and Health
- Phytochemicals and Antioxidant Activities
- Plant-based Medicinal Research
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Bioactive Compounds
- Tryptophan and brain disorders
- Antioxidants, Aging, Portulaca oleracea
- Growth Hormone and Insulin-like Growth Factors
- Biochemical effects in animals
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Immune cells in cancer
- Hydrogen's biological and therapeutic effects
Kunming University
2025
Xi'an Jiaotong University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
China Academy of Chinese Medical Sciences
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Beijing University of Chinese Medicine
2016-2023
Université de Montréal
2023
Zhongda Hospital Southeast University
2019-2022
Aim. In routine histopathology, decalcification is an essential step for mineralized tissues. The purpose of this study to evaluate the effects different solutions on morphological and antigenicity preservation in Sprague Dawley (SD) rat femurs. Materials Methods. Four were employed remove mineral substances from femurs, including 10% neutral buffered EDTA, 3% nitric acid, 5% 8% hydrochloric acid/formic acid. Shaking low temperature used process samples. stainings hematoxylin-eosin (HE)...
Gut dysbiosis and oxidative stress may trigger senile osteoporosis. Fructus Ligustri Lucidi (FLL) has bone-preserving properties affects the intestinal microecology. However, mechanism of anti-osteoporotic effect FLL its link to gut microbiota remains be elucidated. Here, we demonstrated that sustained exposure ICR mice D-galactose / sodium nitrite for 90 days causes aging-related osteoporosis reduced cognitive performance. The aging phenotype is also characterized by increased in serum....
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovitis and cartilage destruction. The active compound, icariin (ICA), derived from the herb Epimedium, exhibits potent anti-inflammatory properties. However, its clinical utility limited water insolubility, poor permeability, low bioavailability. To address these challenges, we developed multifunctional drug delivery system—adipose-derived stem cells-exosomes (ADSCs-EXO)-ICA to target macrophages in synovial...
Background/Aims: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed investigate potential effects of on mice fed high-fat diet (HFD) explore possible mechanisms involved. Methods: Male C57BL/6J an HFD for 12 weeks were supplemented (40 mg/kg/day) via gavage additional 8 weeks....
Salvianolic acid B prevents body weight gain and improves insulin sensitivity in obese mice. The underlying mechanism behind these effects may be associated with the regulation of metabolic endotoxemia, gut microbiota homeostasis LPS/TLR4 pathway.
Purpose: Increasing evidence supported that semaphorin 3A (Sema3A), insulin-like growth factor (IGF)-1 and β-catenin were involved in the development of osteoporosis diabetes. This study is aimed to evaluate whether Sema3A/IGF-1/β-catenin directly alterations bone microarchitecture strength diabetic rats. Methods: Diabetic rats induced by streptozotocin high fat diet exposure. Bone femurs evaluated micro-CT scanning, three-point bending examination stainings HE, alizarin red S safranin...
Purpose: This study is designed to explore whether Fructus ligustri lucidi (FLL) exhibits antioxidant effect in ovariectomized (OVX) rats, and identify the signaling pathway involved this process. Methods: OVX rats were treated with FLL aqueous extract (3.5 g/kg) for 12 weeks. Serum, uteri, tibias harvested from levels of total capacity (TAC), nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy-desoxyguanosine (8-OHdG), superoxide dismutase (SOD) determined. Changes NF-κB-p65,...
This study was aimed at examining the effects of lycopene on bone metabolism in high-fat diet (HFD)- induced obese mice and to identify potential underlying mechanisms. Mice were fed a HFD for 12 weeks then continue with or without intervention (15 mg/kg) additional 10 weeks. The blood glucose lipid metabolism, as well serum levels total antioxidant capacity (T-AOC), superoxide dismutase (SOD), malondialdehyde (MDA) determined by biochemical assays. Bone histomorphological features...
In diabetic islets, the infiltration of macrophages into intra-islets triggers islet β cells dysfunction. Lycopene may preserve M1/M2 macrophage homeostasis to improve function via TLR4/MyD88/NF-κB signaling pathway.
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt hydrolyzes glucose-derived to glycerol, counters metabolic and promotes healthy aging in C. elegans. However, mechanism whereby G3PP activation extends healthspan lifespan, particularly under glucotoxicity, remained unknown. Here, we show overexpression of elegans...
ObjectivesOsteoporosis (OP) is characterized by reduced bone mass and impaired microstructure. Paeoniflorin (PF) isolated from peony root with anti-inflammatory, immunomodulatory, bone-protective effects. Up to now, the mechanism of anti-OP in PF has not been completely clarified.MethodsThe expression MEDAG osteoclasts, osteoblasts adipocytes was detected RT-qPCR. The OVX mouse model constructed, oral administration performed for 15 weeks. Bone microstructure H&E staining a micro-CT system,...
Exposure to Ti 3 C 2 T x leads metabolic disorders in Microcystis aeruginosa , reducing the photosynthetic efficiency and growth of algal cells.