A5034178242- Pituitary Gland Disorders and Treatments
- Air Quality and Health Impacts
- Gut microbiota and health
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Sepsis Diagnosis and Treatment
- Nanoparticles: synthesis and applications
- Pharmacogenetics and Drug Metabolism
- Immune Response and Inflammation
- Medical and Biological Ozone Research
- Glioma Diagnosis and Treatment
- Air Quality Monitoring and Forecasting
- Drug-Induced Hepatotoxicity and Protection
- Lipid Membrane Structure and Behavior
- Ophthalmology and Eye Disorders
- Hereditary Neurological Disorders
- Metabolomics and Mass Spectrometry Studies
- Barrier Structure and Function Studies
- Glutathione Transferases and Polymorphisms
Huashan Hospital
2022-2024
Fudan University
2022-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2023
Shanghai Clinical Research Center
2022-2023
Academy of Military Medical Sciences
2018-2020
Dysbiosis of gut microbiota is associated not only with intestinal disorders but also numerous extraintestinal diseases. Growth hormone-secreting pituitary adenoma (GHPA) an insidious disease persistent hypersecretion GH and IGF-1, causing increased morbidity mortality.
Despite its high mortality, specific and effective drugs for sepsis are lacking. Decoy receptor 3 (DcR3) is a potential biomarker the progression of inflammatory diseases. The recombinant human DcR3-Fc chimera protein (DcR3.Fc) suppresses responses in mice with sepsis, which critical improving survival. Fc region can exert detrimental effects on patient, endogenous peptides highly conducive to clinical application. However, mechanisms underlying DcR3 unknown. Herein, we aimed demonstrate...
Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and explore potential correlations between parameters clinical indices. Subjects methods: enrolled total 109 craniopharyngioma. utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Depression (PHQ9) Pittsburgh Sleep Index prospectively evaluated their QoL. [...]
Abstract Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, cognitive impairments. The roles of gut microbiome serum metabolome in CP‐associated hypothalamic are aimed to be explored. Patients characterized by increased Shannon diversity, Eubacterium , Clostridium Roseburia alongside decreased Alistipes Bacteroides . CP‐enriched taxa...
Abstract Objective The aim of this study was to investigate the gut microbial signatures and related pathophysiological implications in patients with Cushing's disease (CD). Design methods Twenty-seven CD 45 healthy controls were enrolled. Based on obtained metagenomics data, we performed correlation, network study, genome interaction group (GIG) analysis. Fecal metabolomics serum enzyme linked immunosorbent assay (ELISA) analysis conducted dichotomized patients. Caco-2 cells incubated...
Objective: To investigate the inflammatory mechanism of nasal instillation fine particulate matter (PM2.5)on hippocampal tissue injury in mice.Methods: Thirty C57BL/6J mice were randomly divided into 3 groups(n=10):control group, low-dose high-dose group. The doses PM2.5 group and 1.5 mg/kg BW 7.5 BW, respectively, control was given saline with an equal volume. Saline sprayed once every other time for 12 times. serum levels tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)...
Acromegaly is characterized by hypersecretion of growth hormone (GH) and insulin-like factor 1 (IGF-1), accompanied a compromise in the perception wellness. The Patient-Assessed Symptom Questionnaire (PASQ) relevant to assessing signs symptoms but mainly used evaluate efficacy pharmacological intervention. To explore perioperative variation symptom severity, divergence between subgroups stratified according clinical outcomes or treatment modalities, interaction scores indices, we...