A5106723772- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Glioma Diagnosis and Treatment
- Ginger and Zingiberaceae research
- Berberine and alkaloids research
- Gastrointestinal motility and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis B Virus Studies
- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and biological activities of Ficus species
- Lipid metabolism and disorders
- Enzyme Production and Characterization
- Lipoproteins and Cardiovascular Health
- Pancreatic and Hepatic Oncology Research
- Protein Hydrolysis and Bioactive Peptides
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Insect Resistance and Genetics
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Zero to Three
2021
University Gastroenterology
2014
Nanjing Medical University
2014
Changzhou No.2 People's Hospital
2014
Atherosclerosis (AS) is the leading cause of heart attacks, stroke, and peripheral vascular disease. Berberine (BBR), a botanical medicine, has diversified anti-atherosclerotic effects but with poor absorption. The aim this study was to develop an effective BBR-entrapped nano-system for treating AS in high-fat diet (HFD)-fed Apoe(-/-) mice, also explore possible underlying mechanisms involved. Three d-α-tocopherol polyethylene glycol (PEG) succinate (TPGS) analogues different PEG chain...
Abstract Atherosclerosis (AS) is associated with high morbidity and mortality, thus imposing a growing burden on modern society. Herb‐derived bicyclol (BIC) versatile bioactive compound that can be used to treat AS. However, its efficacy in AS not yet described. Here, it shown BIC normalizes gut microflora dysbiosis induced by fat diet Apoe (−/−) mice. Metagenome‐wide association study analysis verifies the modulation carbohydrate‐active enzymes short‐chain fatty acid generating genes flora...
Cholesteryl esters (CEs) are formed by the 3-hydroxyl group of cholesterol and a fatty acyl chain through an ester bond function as biologically inert storage form cholesterol. Abnormal CE levels often related to various diseases, particularly hyperlipidemia atherosclerosis. Herein, we developed mathematical model-assisted ultrahigh performance liquid chromatography–mass spectrometry (UHPLC-MS) method for untargeted identification targeted quantification CEs in plasma, different density...
We investigated the clinical significance of RUNX3 gene expression in human pancreatic carcinoma. Five samples tissues and 30 cancer paracancerous were collected. was detected by real-time PCR immunohistochemistry. The relationships between clinicopathological findings analyzed. relative quantification level mRNA carcinoma 2.60 (0.42-12.82) 1.02 (0.19-3.58), respectively (P < 0.05). percentage positive cells expressing protein 45.5 ± 26.2 6.9 6.0%, 0.01). high group (N = 9) with 45.5% or...
Atherosclerosis Treatment Herb derived drugs modulate gut microbiome homeostasis and gut-generated bio-metabolites. In article number 2105021, Jian-Dong Jiang, Yongsheng Che, Lu-Lu Wang, co-workers modify the immune cell dynamics liver function using herb-derived bicyclol, leading to improved chronic inflammation cholesterol metabolism. The endothelial activation ester accumulation in aortic arch are ameliorated causing less plaque onset.