A5010304991- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer survivorship and care
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Palliative Care and End-of-Life Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Delphi Technique in Research
- Lung Cancer Treatments and Mutations
- Childhood Cancer Survivors' Quality of Life
- Health, psychology, and well-being
- Pediatric health and respiratory diseases
- Family and Patient Care in Intensive Care Units
- Nursing Diagnosis and Documentation
- Health Systems, Economic Evaluations, Quality of Life
- Voice and Speech Disorders
- Patient-Provider Communication in Healthcare
- Cystic Fibrosis Research Advances
- Surfactants and Colloidal Systems
- Child and Adolescent Psychosocial and Emotional Development
University of Manchester
2016-2025
The Christie NHS Foundation Trust
2016-2025
Manchester Academic Health Science Centre
2016-2025
Hong Kong Polytechnic University
2024-2025
University of Newcastle Australia
2019-2024
King's College London
2024
The Christie Hospital
2018-2024
Education Trust
2024
University of Surrey
2023
Cancer Research UK
2023
<h3>Rationale:</h3> Dyspnoea is a debilitating and distressing symptom that reflected in different verbal descriptors. Evidence suggests dyspnoea, like pain perception, consists of sensory quality affective components. The objective this study was to develop an instrument measures overall dyspnoea severity using descriptors reflect its aspects. <h3>Methods:</h3> 81 were administered 123 patients with chronic obstructive pulmonary disease (COPD), 129 interstitial lung 106 heart failure. These...
Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researchers and research funders. Using Delphi method, questions statements were generated via expert group consultations one-to-one interviews (n=17). These subsequently circulated in three survey rounds (n=34, n=25, n=31) to an extended international from various settings...
There are inconsistencies in the literature regarding prevalence and assessment of chemotherapy-induced peripheral neuropathy (CIPN). This study explored CIPN natural history its characteristics patients receiving taxane- platinum-based chemotherapy. Multi-country multisite prospective longitudinal observational study. Patients were assessed before commencing three weekly during chemotherapy for up to six cycles, at 6,9, 12 months using clinician-based scales (NCI-CTCAE; WHO-CIPN criterion),...
The aim of this study was to develop a measure the impact pulmonary hypertension (PH) on health-related quality life (HRQoL) as there is need for short, validated instrument that can be used in routine clinical practice. Interviews were conducted with 30 PH patients derive 32 statements, which presented semantic differential six-point scale (0–5), contrasting adjectives at each end. This item list completed by attending clinics across UK and Ireland. Rasch analysis applied identify items...
<h3>Rationale</h3> The St George9s Respiratory Questionnaire (SGRQ) is often applied to assess health-related quality of life in patients with idiopathic pulmonary fibrosis (IPF). Some SGRQ items will inevitably have weaker measurement properties than others when this population. This study was conducted develop an IPF-specific version the SGRQ. <h3>Methods</h3> Data from a recently completed trial that enrolled subjects IPF (n=158) who and other measures were analysed at baseline 6 months....
This study was conducted to explore the interrelationships among caregiver burden, emotional status and quality of life (QoL) in caregivers lung cancer patients, identify whether burden health are associated with patient QoL. Forty-three dyads patients their were included for analysis. Caregiver-reported outcomes measured by Caregiver Burden Scale (CBS), Caregivers Quality Life Index-Cancer (CQOLC) Hospital Anxiety Depression (HADS), while patient-reported collected HADS Lung Cancer Symptom...
Abstract Background Chemotherapy‐induced peripheral neuropathy (CIPN) is a significant and difficult to manage side effect of neurotoxic chemotherapies. Several risk factors for CIPN have been identified date, but inconsistencies methodological limitations exist in past research. Also, limited number potential has investigated the past. Aim The objective this study was assess relative contribution wider range development CIPN. Methods This analysis used 6‐month data after starting...
<h3>Objective</h3> Older cancer patients are underrepresented in the pivotal trials of checkpoint inhibitors (CPIs). This study aimed to investigate impact an ageing immune system on CPI-related toxicity and provide evidence for role geriatric assessments with CPI. <h3>Methods</h3> The ELDERS is a prospective observational two cohorts: older (70+ years age) younger (<70 age). Patients advanced/metastatic non-small-cell lung or melanoma starting single-agent CPI were eligible. cohort was...
Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting asthma anxiety/depression poorly understood. The study objective is to determine anxiety depressive symptoms in asthma.Severe participants (N = 140) underwent a multidimensional assessment. Categorization were based on HADS scale sub-scores divided into four groups (< 8 both subscales; ≥ one subscale; subscales). Clinical compared between subgroups. Multivariate logistic...
Breathlessness, cough and fatigue are distressing symptoms for patients with lung cancer. There is evidence that these three form a discreet symptom cluster. This study aimed to feasibly test new non-pharmacological intervention the management of Respiratory Distress Symptom Cluster (breathlessness-cough-fatigue) in cancer.This was multi-centre, randomised controlled non-blinded parallel group feasibility trial. Eligible (patients primary cancer 'bothered' by at least two cluster symptoms)...
Pulmonary Hypertension Association UK (PHA-UK) is the only charity in especially for people affected by pulmonary hypertension (PH). To better understand impact of PH on patients and carers beyond clinical symptoms, PHA-UK carried out a cross-sectional survey effect daily living, along with follow-up assessing financial PH.This descriptive adult UK. A quantitative four key topics (time to diagnosis, quality life [QoL], specialist treatment), was made available members therapy, sent those...
Clinical trials evaluating the management of acute exacerbations COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, consensus-based minimum set outcomes we recommend evaluated in all future clinical on management, improve their quality and comparability. were identified through methodological systematic reviews qualitative interviews with 86 patients from 11 countries globally. The most...
Cancer and its treatment can have significant impacts on health status, quality of life functioning patients. Direct information from patients regarding these aspects be collected via electronic platforms in the form Patient Reported Outcome Measures (ePROMs). Research has shown that use ePROMS cancer care leads to improved communication, better symptom control, prolonged survival a reduction hospital admissions emergency department attendance. Acceptability feasibility routine ePROM...
Background. Dyspnea is a prominent symptom in asthma. The Dyspnea-12 (D-12), an instrument that quantifies breathlessness using 12 descriptors tap the physical and affective aspects, has shown promise for measurement of dyspnea cardiorespiratory disease. Objective. We report results study designed to test validity reliability D-12 population patients with Methods. This cross-sectional included 102 Subjects completed D-12, Hospital Anxiety Depression scale, St. George's Respiratory...