A5101908682- Heart Rate Variability and Autonomic Control
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Sunflower and Safflower Cultivation
- Cancer Research and Treatments
- Neurobiology and Insect Physiology Research
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- Cardiac Imaging and Diagnostics
- Luminescence Properties of Advanced Materials
- Perovskite Materials and Applications
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Coronary Interventions and Diagnostics
- Receptor Mechanisms and Signaling
- Medical Research and Treatments
- Acute Myocardial Infarction Research
- Advancements in Semiconductor Devices and Circuit Design
- RNA Interference and Gene Delivery
- Liver Disease and Transplantation
- Stress Responses and Cortisol
- High Altitude and Hypoxia
- Neonatal and fetal brain pathology
- Phytochemical and Pharmacological Studies
- Microwave Dielectric Ceramics Synthesis
National Center for Nanoscience and Technology
2021-2023
Guangxi Medical University
2023
Fourth People's Hospital of Taiyuan
2023
First Affiliated Hospital of Zhengzhou University
2022
Beijing Anzhen Hospital
2018-2019
Capital Medical University
2018-2019
Capital University
2019
Harbin Medical University
2014-2018
Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and limited flexibility of bacterial approach call for improvement. Inspired by health benefits probiotics in alleviating symptoms diseases, bioartificial are designed restore intestinal microenvironment colitis regulating redox balance, immune responses, gut microbiome. The probiotic comprises two components: an E. coli Nissle 1917-derived membrane...
Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression drug release should be spatiotemporally controlled to avoid in healthy tissues undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating orthotopic colon tumors female mice, the paramagnetic...
The complete regression of residual tumors after photothermal therapy (PTT) depends on the activation and recognition immune system. However, inevitable local inflammation PTT in tumor recruits abundant abnormal cells, especially tumor-associated macrophages (TAMs) which further promote escape survival remaining resulting recurrence progression. To solve this problem, herein we explored biomimetic nanoparticles carrying repolarization agent TAMs to remodel post-PTT inflammatory...
Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L. In this study, we aimed to evaluate effects HSYA on ovalbumin (OVA)-induced asthma in guinea pigs, and elucidate underlying mechanisms. We established a pig model by intraperitoneal injection atomized administration OVA. Guinea pigs were injected intraperitoneally with (50, 75, 112.5 mg/kg) once daily from days 2 22 before OVA administration. examined biomarkers including lung function,...
Nanocarriers with intrinsic immune adjuvant properties can activate the innate system while delivering tumor antigen, thus efficiently facilitating antitumor adaptive immunity. Bacteria-derived outer membrane vesicles (OMVs) are an excellent candidate due to their abundance of pathogen associated molecular patterns. However, during uptake OMVs by dendritic cells (DCs), interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation blockage, a phenomenon we refer...
Hydroxysafflor yellow A (HSYA) is the main active ingredient of edible plant safflower. HSYA has demonstrated anti-inflammatory effects. The inflammatory response key mechanism responsible for asthma, and pro-inflammatory platelet-activating factor (PAF) known to play a role in pathology bronchial asthma. In this study, we stimulated human smooth muscle cells (HBSMCs) with PAF examined effects on resulting asthma-related process. stimulation induced HBSMC activation, proliferation, increased...
The territory of the right coronary artery (RCA) is smaller than that left anterior descending artery. Previous studies have reported conflicting results when considering whether stable RCA-chronic total occlusion (CTO) should be reopened. coexistence diabetic and diseases represents a severe situation. Therefore, we aimed to determine if RCA-CTO in patients was necessary To our knowledge, no focused on this topic date. We enrolled with who had clinical presentations symptomatic angina or...
In tumor nanovaccines, nanocarriers enhance the delivery of antigens to antigen-presenting cells (APCs), thereby ensuring robust activation antigen-specific effector T-cells kill cells. Through employment their high immunogenicity and nanosize, we have developed a "Plug-and-Display" platform on basis bacterial outer membrane vesicles (OMVs) for nanovaccines (NanoVac), which can rapidly display different efficiently eliminate lung metastases melanoma. this study, first upgraded NanoVac...
Hydroxysafflor yellow A (HSYA) is a chemical component isolated from the Chinese medicine Carthamus tinctorius L. HSYA has numerous pharmacological effects, including protecting against and mitigating some respiratory diseases such as acute lung injury chronic obstructive pulmonary disease; however, its effect on asthma remains unclear. We previously found that attenuated ovalbumin-induced allergic in guinea pigs. Platelet activating factor (PAF) phospholipid mediator of inflammation an...
As implemented in the commercialized device modeling software, four-state nonradiative multi-phonon model has attracted intensive attention past decade for describing physics negative bias temperature instability (NBTI) and other reliability issues of Si/SiO$_\text{2}$ MOSFET devices. It was proposed initially based on assumption that oxygen vacancy defects (V$_\text{O}$) SiO$_\text{2}$ dielectric layer are bistable Si-dimer back-projected structures during carrier capture emission. Through...
Objective: To compare the differences in prevalence of mild micro-hepatic encephalopathy (MHE) among patients with cirrhosis by using psychometric hepatic score (PHES) and Stroop smartphone application (Encephal App) test. Methods: This prospective, multi-center, real-world study was initiated National Clinical Medical Research Center for Infectious Diseases Portal Hypertension Alliance registered International ClinicalTrials.gov (NCT05140837). 354 cases were enrolled 19 hospitals across...