Autophagy is essential for maintaining both survival and health of cells. normally suppressed by amino acids insulin. It unclear what happens to the autophagy activity in presence insulin resistance hyperinsulinemia. In this study, we examined hyperinsulinemia associated mechanism. Insulin were induced mice a high fat diet, followed measurements markers. Our results show that was livers with Transcript levels some key genes also Conversely, increased streptozotocin-induced deficiency. Levels...

Abstract Background Glucose variability is one of components the dysglycemia in diabetes and may play an important role development diabetic vascular complications. The objective this study was to assess relationship between glycemic determined by a continuous glucose monitoring (CGM) system presence severity coronary artery disease (CAD) patients with type 2 mellitus (T2DM). Methods In 344 T2DM chest pain, angiography revealed CAD (coronary stenosis ≥ 50% luminal diameter narrowing) 252 92...

Dysglycemia is associated with poorer prognosis in patients acute myocardial infarction (AMI). Whether admission glycemic variability (GV) has important value of AMI still unknown. The aim the study to investigate prognostic GV, glucose, and glycosylated hemoglobin (HbA(1c)) patients.We measured blood HbA(1c), GV on 222 consecutive diagnosed AMI. indicated as mean amplitude excursions (MAGE), was determined by a continuous glucose monitoring system. MAGE categorized ≥3.9 or <3.9 mmol/L,...

We sought to investigate the characteristics, survival and risk factors for mortality in Chinese patients with connective tissue disease (CTD)-associated pulmonary arterial hypertension (APAH) modern therapy era. 129 consecutive adult who visited one of three referral centres China a diagnosis CTD-APAH confirmed by right heart catheterisation during previous 5 years were enrolled. The end-point was all-cause death or data censoring. Systemic lupus erythematosus most common underlying CTD...

A majority of subjects with insulin resistance and hyperinsulinemia can maintain their blood glucose levels normal for the whole life presumably through protein kinase B (Akt)-dependent signaling. In this study, we found that basal Akt phosphorylation level was increased in liver gastrocnemius mice under high-fat diet (HFD). Levels mitochondrial DNA expression some mitochondrion-associated genes were decreased by HFD primarily liver. Triglyceride content both HFD. Oxidative stress induced...

Growing evidence suggests that epicardial adipose tissue (EAT) may play a key role in the pathogenesis and development of coronary artery disease (CAD) by producing several inflammatory adipokines. Chemerin, novel adipokine, has been reported to be involved regulating immune responses glucolipid metabolism. Given these properties, chemerin provide an interesting link between obesity, inflammation atherosclerosis. In this study, we sought determine relationship expression EAT severity...

Subjects with type 1 diabetes mellitus (T1DM) eventually develop insulin resistance and other features of T2DM such as cardiovascular disorders. The exact mechanism has been not completely understood. In this study, we tested the hypothesis that excessive or inappropriate exposure to is a primary mediator in T1DM. We found continuous mice non-obese detemir, which similar some current conventional treatment human T1DM, induced severe resistance, whereas untreated hyperglycemia for same amount...

Abstract Background Acute phase hyperglycemia has been associated with increased mortality in patients acute myocardial infarction (AMI). However, the predictive value of glycemic excursion for adverse outcome elderly AMI is not clear. The aim this study to investigate prognostic early in-hospital and hemoglobin A 1c (HbA ) one-year major cardiac event (MACE) AMI. Methods We studied 186 patients, whose clinical data were collected Global Registry Coronary Events (GRACE) risk score calculated...

Abstract Lung adenocarcinoma (LUAD) is a common type of lung cancer with high incidence and poor prognosis. Hypoxia DNA methylation play important regulatory roles in progression. The purpose the present study was to explore relationship between hypoxia methylation, identify key genes for hypoxia-regulated LUAD score (HS) calculated using GSVA algorithm. Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment protein–protein interaction (PPI) analysis were performed...

Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum levels in MetS as well their association various parameters humans. A total 131 consecutive patients MetS, 162 age-matched, healthy subjects were recruited for this study. Serum concentrations determined using enzyme-linked immunosorbent assay. Lipid...

Abstract Background and Objectives Hyperglycemia is associated with adverse outcomes in patients acute myocardial infarction (AMI) as well heart failure. However, the significance of admission glycemic variability (GV) predicting among diabetes failure (HF) following ST-segment elevation (ASTEMI) remains unclear. This study aims to explore prognostic value GV glycosylated hemoglobin (HbA1c) levels individuals diagnosed type 2 HF ASTEMI. Methods We measured HbA1c upon 484 consecutive GV,...

The primary player that induces insulin resistance has not been established. Here, we studied whether or fat can cause in the presence of deficiency. Our results showed high-fat diet (HFD) induced C57BL/6 (B6) mice. HFD-induced was prevented largely by streptozotocin (STZ)-induced moderate STZ-induced deficiency ectopic accumulation and oxidative stress liver gastrocnemius. HFD- insulin-induced increase hepatic expression long-chain acyl-CoA synthetases (ACSL), which are necessary for fatty...

Agranulocytosis is a rare adverse effect of methimazole. The usual duration treatment prior to the onset agranulocytosis approximately 1 4 months, and can be as long year. together with hepatotoxicity an extremely idiosyncratic side methimazole treatment. We present unprecedented case Grave's disease patient who showed strong reaction obvious which developed only six days after administration. This case, along literature review, offered aim increase awareness physicians sudden from

Severe calorie restriction (CR) is shown to improve or even reverse β-cell dysfunction in patients with obesity and type 2 diabetes mellitus. However, whether mild moderate CR can induced by the underlying mechanism remain unclear. Autophagy plays an important role maintaining mass, architecture function of β-cells. While impact on autophagy unknown. This study aims investigate effects activity diet-induced obese (DIO) mice.DIO C57BL/6 mice were subjected 3 weeks switching normal chow (HF →...

Admission hyperglycemia is associated with increased mortality and major adverse cardiac events (MACE) in patients or without diabetes mellitus after acute myocardial infarction (AMI). However, effects of glycemic variability (GV) on outcomes non-diabetes AMI still remains unclear. The aim this study to compare the prognostic value in-hospital GV admission blood glucose (ABG) for 3-month MACE ST elevation (STEMI) who underwent percutaneous coronary intervention (PCI).We analyzed 256 STEMI...

VEGF is critical in the pathogenesis of malignant pleural effusion (MPE). To understand clinical benefits antiangiogenic agents, efficacy chemotherapy containing bevacizmab was investigated patients with lung adenocarcinoma-induced MPE.The data adenocarcinoma MPE treated bevacizumab plus on day 1, every three weeks, for ≤ 6 cycles retrospectively collected. Patients who achieved a response or stable disease were administered as maintenance therapy until progression. The primary outcomes...