A5102891713- Bone Tissue Engineering Materials
- Advanced Sensor and Energy Harvesting Materials
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- MicroRNA in disease regulation
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Axon Guidance and Neuronal Signaling
- Erythrocyte Function and Pathophysiology
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Connexins and lens biology
- Bone health and osteoporosis research
- Hereditary Neurological Disorders
- Circular RNAs in diseases
- Virus-based gene therapy research
- Bone and Joint Diseases
- Medical and Biological Sciences
- Nerve injury and regeneration
- biodegradable polymer synthesis and properties
- Ion channel regulation and function
Hainan Eye Hospital
2025
Sun Yat-sen University
2025
Sichuan University
2015-2024
West China Hospital of Sichuan University
2016-2024
Jinan University
2020
Peking Union Medical College Hospital
2018
State Key Laboratory of Oral Diseases
2013-2015
Chinese University of Hong Kong
2011-2015
University of Hong Kong
2011-2015
Stomatology Hospital
2015
Abstract Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed nerves, mechanical loads-induced withdrawal using orthodontic tooth movement (OTM) model. Firstly, was activated after 3rd day OTM, coinciding with a decrease nerves an increase pain threshold. Sema3A, rather than growth factor (NGF), highly both trigeminal ganglion axons periodontal ligament following OTM. Moreover,...
Three-dimensional (3D)-printed biodegradable polymer scaffolds are at the forefront of personalized constructs for bone tissue engineering. However, it remains challenging to create a biological microenvironment growth. Herein, we developed novel yet feasible approach facilitate biomimetic mineralization via self-adaptive nanotopography, which overcomes difficulties in surface biofunctionalization 3D-printed polycaprolactone (PCL) scaffolds. The building blocks nanotopography were PCL...
Background Dysthyroid optic neuropathy (DON), the most severe complication of thyroid eye disease (TED), has unclear mechanisms and unsatisfactory treatment outcomes. This study aimed to identify key pathways inflammation-related core genes driving DON progression, potentially informing new therapeutic strategies improving management. Methods Retro-orbital tissues from DON, non-DON TED, healthy controls (HCs) were analyzed using bulk RNA sequencing. Differentially expressed (DEGs) identified...
Aberrant expression of microRNAs (miRs) serves essential roles in the generation and progression various types human cancer. In present study, biological functions miR-381 gastric carcinoma (GC) were focused upon. The results reverse transcription-quantitative polymerase chain reaction analysis revealed that was significantly downregulated GC tissue samples. Furthermore, low identified to be associated with lymphatic metastasis advanced tumor-node-metastasis stage (III+IV). Upregulation...
Abstract Parathyroid hormone (PTH) plays crucial role in maintaining calcium and phosphorus homeostasis. In the progression of secondary hyperparathyroidism (SHPT), expression calcium-sensing receptors (CaSR) parathyroid gland decreases, which leads to persistent hypersecretion PTH. How precisely manipulate PTH secretion tissue underlying molecular mechanism is not clear. Here, we establish an optogenetic approach that bypasses CaSR inhibit human hyperplastic cells. We found stimulation...
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation that eventually leads to joint destruction. Treatment for RA primarily consists of cytokine inhibitors, B cell‐depleting agents, and T cell costimulatory blocking agents. In recent years, miRNAs have come into play with better therapeutic results less side effects, yet their clinical use often limited structural instability. By incorporating miR‐23b the structure tFNAs form complex...
The effective regeneration of large bone defects via tissue engineering is challenging due to the difficulty in creating an osteogenic microenvironment. Inspired by fibrillar architecture natural extracellular matrix, we developed a nanoscale bioengineering strategy produce fibril-like composite scaffolds with enhanced capability. To activate surface for biofunctionalization, self-adaptive ridge-like nanolamellae were constructed on poly(ε-caprolactone) (PCL) electrospinning surface-directed...
One-dimensional conducting polymer nanostructure arrays could provide short ion transport paths, thus delivering superior chemical/physical performance and having large potential as intelligent switching materials. In this work, in situ electrochemical atomic force microscopy is employed to monitor the self-assembly of polypyrrole nanotube template-free polymerization. The specific spreading behavior pyrrole micelles on conductive substrate important large-area insight into discussed....
In this study, pore size and porosity distribution of porous Ti-6Al-4V scaffolds (pTi) were controlled by 3D printing. The effects at a constant porosity, or pertaining to functions adhesion, proliferation, differentiation the mouse embryonic osteoblast precursor (MC3T3-E1) cells researched separately.3D printing was used design five groups pTi, designated as PS300/HP, PS300/LP, PS500/HP, PS500/LP, PS800/HP based on distribution. MC3T3-E1 cultured non-porous samples (npTi) prepared control....