A5101953532- Water resources management and optimization
- Hydrology and Watershed Management Studies
- Spine and Intervertebral Disc Pathology
- Immune Cell Function and Interaction
- Electrospun Nanofibers in Biomedical Applications
- Advanced Glycation End Products research
- Spinal Fractures and Fixation Techniques
- Flood Risk Assessment and Management
- Cancer-related molecular mechanisms research
- Water-Energy-Food Nexus Studies
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Antimicrobial Peptides and Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone Tissue Engineering Materials
- Scoliosis diagnosis and treatment
- Hemostasis and retained surgical items
- Hydrology and Drought Analysis
- Cervical and Thoracic Myelopathy
- Remote Sensing and LiDAR Applications
- Machine Learning in Bioinformatics
- Wind and Air Flow Studies
Changjiang Water Resources Commission
2022-2025
Sun Yat-sen University
2009-2024
Beijing Normal University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2021-2024
Xuzhou Medical College
2023-2024
Third Affiliated Hospital of Zhengzhou University
2022
Yangtze University
2022
Third Affiliated Hospital of Southern Medical University
2014-2021
China Agricultural University
2019-2021
Wuhan University
2007-2020
The hydrological cycle, affected by climate change and rapid urbanization in recent decades, has been altered to some extent further poses great challenges three key factors of water resources allocation (i.e., efficiency, equity sustainability). However, previous studies usually focused on one or two aspects without considering their underlying interconnections, which are insufficient for interaction cognition between hydrology social systems. This study aims at reinforcing management all...
Abstract Rainfall and wind speed are two important meteorological variables that have a significant impact on agriculture, human health, socio-economic development. While individual rainfall or events been widely studied, little attention has devoted to studying the lead–lag relationship between speed, particularly in coastal regions where strong dependence is expected. Taking China's coastline as case study, this paper aims explore variation trends of reveal relationships speeds days before...
In Brief Study Design. To examine the effects of a tumor necrosis factor (TNF)-α antagonist (etanercept) on rat spinal cord injury and identify possible mechanism for its action. Objective. elucidate contribution etanercept to pathologic cascade in suppression neuronal oligodendroglial apoptosis. Summary Background Data. Etanercept has been recently used successfully treatment inflammatory disorders. However, only few studies have examined role suppressing apoptosis injury. Methods. or...
Object The surgical approach and treatment of thoracolumbar osteoporotic vertebral collapse with neurological deficit have not been documented in detail. Anterior surgery provides good decompression solid fusion, but the surgery-related risk is relatively higher than that associated posterior approach. In surgery, major problem after correction instrumentation failure to support anterior spinal column, leading loss kyphosis. aim this study was evaluate efficacy reinforcing short-segment...
Abstract Introduction Ossification of the ligamentum flavum (OLF) spine is associated with serious neurologic compromise, but pathomechanism this process remains unclear. The objective study was to investigate ossification process, including roles various transcriptional factors in human thoracic flavum. Methods Sections were obtained from 31 patients OLF who underwent posterior decompression, and six control free OLF. Cultured cells ( n = 6, each) examined real-time reverse...
In Brief Study Design. To examine the localization and expression of high-mobility group box-1 (HMGB-1) protein its receptors after rat spinal cord injury. Objective. elucidate contribution HMGB-1 as potential candidates in a specific upstream pathway to proinflammatory response leading cascade secondary tissue damage Summary Background Data. was recently characterized key cytokine with role nucleosome formation regulation gene transcription. No studies have investigated Methods. Injured...
The majority of chitosan-based bone tissue engineering (BTE) scaffolds have the problem poor mechanical properties. However, modifying chitosan with conventional silane coupling agents to improve properties will introduce additional complications, including cytotoxicity and biocompatibility. In this study, two types organic–inorganic composite (F-A-T0/T3/T5 F-B-T5-P0/P0.5/P1.5/P2.5) were prepared using nanofibers (CSNF) by beating-homogenization method, combined sol–gel further introduced...
In Brief Study Design. A prospective clinical trial was conducted. Objective. To compare the and radiologic late results of monosegmental transpedicular fixation versus short-segment pedicle instrumentation (SSPI) in management thoracolumbar burst fractures evaluate efficacy fixation. Summary Background Data. SSPI (1 level above 1 below fracture level) are accepted by many surgeons as an technique for treatment fractures. preserve more motion segments, some authors have advocated (MSPI). The...
The butyrophilins represent a unique family of immunoglobulin. They were considered to be involved in milk lactation after their discovery 1981. With the development research, an increasing number researches revealed that play important roles immune regulation [1992-2019]. Our research aimed summarize butyrophilin status and relationship with lung cancers breast by bibliometric bioinformatic methods. results indicate on immune-regulatory functions gradually developed from 1992 2006, whereas...
Abstract Liver fibrosis represents a severe stage of liver damage, with hallmarks inflammation, hepatic stellate cell activation, and extracellular matrix accumulation. Although previous studies demonstrated γδ T cells are involved in fibrosis, the precise role mechanisms migrating to fibrotic have not been elucidated. Here, we aim investigate functional subsets further explore underlying causes drivers migration. In this study, observed that accumulate liver. Adoptive transfer T, especially...
Abstract Quantification of the inherent uncertainty in hydrologic forecasting is essential for flood control and water resources management. The existing approaches, such as Bayesian model averaging (BMA), processor (HUP), copula-BMA (CBMA), aim at developing reliable probabilistic forecasts to characterize induced by structures. In probability forecast framework, these approaches either assume density function (PDF) follow a certain distribution, or are unable reduce bias effectively...
Purpose: The purpose of this study is to evaluate the effects miR-628 on migration and invasion breast cancer stem cells (CSCs), which are essential for tumor recurrence metastasis. Materials methods: Quantitative reverse transcription-polymerase chain reaction was used determine expression microRNAs mRNAs. A subpopulation CD44 + /CD24 - CSCs were sorted by flow cytometry. Transwell assays cell invasion. Luciferase reporter performed verify whether targeted SOS Ras/Rac guanine nucleotide...
Abstract As the water source for middle route of South-to-North Water Transfer Project, Han River in China plays a role world’s largest inter-basin transfer project. However, this human-interfered area has suffered from over-standard pollution emission and blooms recent years, which necessitates urgent awareness at both national provincial scales. To perform comprehensive analysis quality condition study area, we apply index (WQI) minimal WQI (WQI min ) methods to investigate spatiotemporal...
This study examined the impacts of agriculture on methane (CH4) and carbon dioxide (CO2) dynamics in an agricultural river eastern China. The dissolved CH4 concentrations (dCH4; 422 ± 188 nmol L–1 summer 193 190 winter) emissions (6430 11,650 μmol m–2 d–1 396 1190 were closely associated with agriculture-enhanced allochthonous inputs methanogenesis by methanogens algae. shallow water depth low flow velocity plain favorable for bubble release. pressure CO2 (pCO2) values substantially higher...
In Brief Study Design. The twy/twy mouse undergoes spontaneous chronic mechanical compression of the spinal cord; this in vivo model system was used to examine effects retrograde adenovirus (adenoviral vector [AdV])-mediated brain-derived neurotrophic factor (BDNF) gene delivery neural cells. Objective. To investigate targeting and potential neuroprotective effect AdV-mediated BDNF transfection chronically compressed cord terms prevention apoptosis neurons oligodendrocytes. Summary...
The present study evaluated the anti‑inflammatory effect of microRNA (miR)‑146a in a spinal cord injury (SCI) rat model and vitro model, explored possible underlying mechanisms this effect. miR‑146a expression was analyzed using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β IL‑6 content measured ELISA kits. Inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), Toll‑like receptor 4 (TLR4), myeloid...
Tyrosinase is a key enzyme responsible for enzymatic browning of fruits and vegetables skin disorders due to overproduction melanin. Arbutin an inhibitor tyrosinase; however, its high polarity weak transdermal absorption capacity limit applications. In this paper, green solvent system was developed successfully synthesize arbutin esters with improved liposolubilities (Clog P values = 0.27–5.03). Among the obtained esters, undecenoate (AU) showed strongest tyrosinase-inhibiting activity...
HMGB1 (high-mobility group box-1) has been extensively studied as a damage-associated molecular pattern, with secreted cytokine function. However, its regulation on T cells, especially the function in nucleus, not elucidated. Here, we use conditional knockout (HMGB1-f/f; CD2-cre) mice and find that potentiates proliferation interferon gamma (IFN-γ) expression of CD8 cells rather than CD4 cells. Notably, nuclear, but secreted, supports IFN-γ via directly regulating activity Eomes,...