Fabricating artificial materials that mimic the structures and properties of tendons is great significance. Possessing a tensile stress approximately 10.0 MPa water content around 60%, human exhibit excellent mechanical to support daily functions. In contrast tendons, most synthetic hydrogels with similar typically exclude qualified strength, swelling resistance, biocompatibility. Herein, facile strategy based on poly(vinyl alcohol) (PVA) tannic acid (TA) demonstrated tackle this problem via...

Abstract As a promising candidate for next‐generation energy storage devices, Zn metal battery excels with their good safety, high specific capacity, and economic attractiveness. However, it still suffers from narrow electrochemical window, notorious dendrite formation, sluggish ion transfer. Aqueous electrolyte engineering has been regarded as an effective way to improve these. It is shown that by adding sodium polystyrene sulfonate (PSS) polymers into dilute 1 m Zn(OTf) 2 aqueous...

Carbon nitride (CxNy) materials, characterized by an ordered two-dimensional without metal ions structure high N:C ratio, phase transition transformation, predispose them for promising applications in catalytic reaction, flexible electronics, broadband photodetectors and battery. However, up to now, its potential advantages gas sensor have yet be fully explored. This review provides a comprehensive overview of recent advances CxNy-based materials applied as substrates covering structure,...

An efficient synthetic procedure for the preparation of fused 2,3-dihydrofuran derivatives was developed with assistance pyridinium ylide. A sequential one-pot, two-step tandem reaction starting from pyridine, aromatic aldehyde, dimedone, or 4-hydroxycoumarin and α-phenacyl bromide p-nitrobenzyl triethylamine as catalyst proceeded smoothly in acetonitrile. 1H NMR spectroscopy single-crystal analysis demonstrated that obtained 2,3-dihydrofurans are trans isomers.

A novel tandem radical cyclization/intermolecular coupling between 2-azaallyl anions and indole N -aryloxy acetamides is developed, which enables the synthesis of C3a-substituted pyrroloindolines under mild conditions.

The dual fluidized bed (DFB) shows great potential for the steam gasification of biomass to produce hydrogen. Understanding hydrodynamics and thermochemical characteristics in a pilot-scale DFB system is crucial optimizing operating conditions devising reactor design. In this study, three-dimensional model, based on multiphase particle-in-cell (MP-PIC) method, developed 100 kW featuring staged reactor. entire simulated, with focus reaction gasifier ignoring reactions combustion basic...

The formation of a solid electrolyte interphase on carbon anodes causes irreversible loss Na+ ions, significantly compromising the energy density Na-ion full cells. Sodium compensation additives can effectively address sodium but suffer from high decomposition voltage induced by low electrochemical activity. Herein, we propose universal electrocatalytic strategy introducing nanotube (CNT)/MnO2 catalyst to realize utilization at much-reduced voltage. well-organized CNT/MnO2 composite with...

Abstract Post-translational modifications (PTMs) of the non-histone protein high-mobility group B1 (HMGB1) are involved in modulating inflammation and immune responses. Recent studies have implicated that RNA-binding (RBP) Musashi-2 (MSI2) regulates multiple critical biological metabolic immunoregulatory functions. However, precise role MSI2 regulating PTMs tumor immunity colorectal cancer (CRC) remains unclear. Here, we present data indicating potentiates CRC immunopathology...

A novel double spot-ring plane-concave multipass cell (DSPC-MPC) gas sensor was proposed for simultaneous detection of trace gases, which has lower cost and higher mirror utilization than the traditional with 129 m, 107 85 63 m 40 effective optical path lengths adjustable. The performance DSPC-MPC evaluated by measuring CO CH4 using two narrow linewidth distributed feedback lasers center wavelengths 1567 nm 1653 nm, respectively. An adjustable digital PID laser frequency stabilization system...

Despite decades of investigations, the principal mechanisms responsible for high affinity and specificity proteins key physiological cations K+, Na+, Ca2+ remain a hotly debated topic. At core debate is an apparent need (or lack thereof) accurate description electrostatic response charge distribution in protein to binding ion. These effects range from partial electronic polarization directly ligating atoms long-range related transfer delocalization effects. While modeling cation recognition...

High-precision spatial-temporal wind power prediction technology is of great significance for ensuring the safe and stable operation grids. The development artificial intelligence provides a new scheme modeling with strong correlation. In addition, existing models are mostly ‘black box’ models, lacking interpretability, which may lead to lack trust in model by grid dispatchers. Therefore, improving obtain interpretability has become an important challenge. this paper, interpretable...

An efficient synthetic procedure for the preparation of unusual charge-separated pyridinium-Meldrum acid and N,N-dimethylbarbiturate zwitterionic salts was developed though a unique one-pot four-component reaction involving pyridine, aromatic aldehyde, Meldrum or N,N-dimethylbarbituric acid, p-nitrobenzyl bromide in acetonitrile. By varying combinations four components nitrogen-containing heterocycles, we conveniently established reactive α-halomethylene compounds, aldehydes β-dicarbonyl...

Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis tumor cells can inhibit their malignant biological behavior as promising therapeutic approach. However, it unclear whether MSI2 regulates cell death in colorectal cancer (CRC), especially underlying mechanisms and effects CRC remain elusive.Experimental methods including qRT‒PCR, immunofluorescence, flow...

Abstract Background: Immune-checkpoint blockade (ICB) therapies have revolutionized cancer treatment, but such immunotherapy regimens fail in a subset of patients. Dendritic cells (DCs) are heterogeneous group professional antigen-presenting innate immune that activate adaptive immunity and determine the efficacy immunotherapies. While they can also be hijacked by tumor-mediated factors to contribute tolerance tumor progression. However, little is known about molecular mechanisms drive...

Abstract To study the bond behavior between Cr alloy rebar and fiber‐reinforced coral aggregate concrete (CAC), anchorage tests reinforcement CAC are conducted. The effects of different water–binder ratios, basalt fiber contents, polypropylene diameters, surface morphologies on form failure adhesion‐displacement curve investigated. bonding strength 72 specimens reinforced is studied, a model established. simplified into rising, falling, residual sections. adhesive distinct from that ordinary...

A density functional theory (DFT) study has been conducted to unveil the mechanisms of tandem oxidative acetoxylation/ortho C–H activation/carbocyclization catalyzed by Pd(OAc)2. The potential competitive reaction pathways between acetoxylation and ortho activation, activation with outer-sphere inner-sphere acetate ligands, role DMSO in have discussed detail. calculated results indicate that proceeds before this a neutral system without as ligand coordinated Pd. six-membered transition state...

Abstract Nephrotoxicity has become prominent due to the increase in clinical use of nilotinib, a second‐generation BCR‐ABL1 inhibitor first‐line treatment Philadelphia chromosome‐positive chronic myeloid leukemia. To date, mechanism nilotinib nephrotoxicity is still unknown, leading lack intervention strategies. Here, it found that could induce glomerular atrophy, renal tubular degeneration, and kidney fibrosis an animal model. Mechanistically, induces intrinsic apoptosis by specifically...

The contamination of Listeria monocytogenes ( L. ) in dairy products poses a significant risk to human health. It is urgent develop on‐site rapid strategy reduce associated threats. We employed carbon dots (CDs) and silicon nanoparticles (SiNPs) as energy donors acceptors respectively. CDs SiNPs were functionalised with vancomycin aptamers correspondingly, leading the establishment ratiometric fluorescent sensor. With portable smartphone‐integrated device, ratios blue/green values from...

Flurbiprofen organic selenium compound RY-1-92 has anticancer activity in non-small cell lung cancer by targeting TRPV1 and its downstream MAPK signaling.