A5002847541- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Cancer Genomics and Diagnostics
- Optimal Experimental Design Methods
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Gene expression and cancer classification
- Veterinary Equine Medical Research
- Genetic factors in colorectal cancer
- Statistical Methods and Bayesian Inference
- Shoulder Injury and Treatment
- Bayesian Methods and Mixture Models
- Veterinary Practice and Education Studies
- COVID-19 epidemiological studies
- Bone fractures and treatments
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Shoulder and Clavicle Injuries
- Bone health and treatments
- Sulfur Compounds in Biology
- Artificial Intelligence in Healthcare and Education
- Bone Tissue Engineering Materials
- Influenza Virus Research Studies
- Genomics and Phylogenetic Studies
- Hip and Femur Fractures
Colorado State University
2020-2024
GS Engineering (United States)
2024
University of Chicago
2019-2023
John Wiley & Sons (United States)
2023
Chicago Department of Public Health
2019-2023
Jinan University
2017-2023
ShenZhen People’s Hospital
2015-2023
Southern University of Science and Technology
2020-2023
Guangzhou University of Chinese Medicine
2022
Iowa State University
2022
The widely recommended procedure of Bayesian model averaging is flawed in the M-open setting which true data-generating process not one candidate models being fit. We take idea stacking from point estimation literature and generalize to combination predictive distributions, extending utility function any proper scoring rule, using Pareto smoothed importance sampling efficiently compute required leave-one-out posterior distributions regularization get more stability. compare several...
Abstract Background Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment primary neuropathies, it condition that should be investigated. FoxO3 activation an indispensable mechanism in denervation‐induced atrophy; however, upstream factors control expression activity have not been fully elucidated. N 6 ‐methyladenosine (m A) methylation novel mode epitranscriptional gene regulation affects several cellular...
Abstract We propose a multiple cohort expansion (MUCE) approach as design or analysis method for phase 1b trials, which are novel first-in-human studies conducted following 1a dose escalation. In trial, one more doses of new investigational drug identified from tested initial antitumour activities in patients with different indications (cancer types and/or biomarker status). Each dose–indication combination defines an arm, and enrolled parallel cohorts to all the arms. The MUCE is based on...
Abstract Background Radiographs are a common diagnostic tool utilised during pre‐purchase examinations, yet differences surround their interpretation among equine veterinarians. Objectives (1) To determine veterinarians' subjective impressions of spectrum radiographic abnormalities regarding suitability for purchase; (2) how years in practice, primary discipline or board certification status influence impression abnormalities, and (3) horses' discipline, current level work (working at...
Background and Objectives Deproteinization is an indispensable process for the elimination of antigenicity in xenograft bones. However, hydrogen peroxide (H2O2) deproteinized xenograft, which commonly used to repair bone defect, exhibits limited osteoinduction activity. The present study was designed develop a new method deproteinization compare osteogenic capacities pepsin bones with those conventional H2O2 ones. Methods Bones were or 8 hours. morphologies compared by HE staining. content...
A basket trial in oncology encompasses multiple "baskets" that simultaneously assess one treatment cancer types or subtypes. It is well-recognized hierarchical modeling methods, which adaptively borrow strength across baskets, can improve over simple pooling and stratification. We propose a novel Bayesian method, RoBoT (Robust Hypothesis Testing), for the data analysis decision-making phase II trials. In contrast to most existing methods use posterior credible intervals determine efficacy of...
To investigate the effect of femoral component valgus/varus angle (FCVA) on mid-term outcome after unicondylar knee arthroplasty.
The spread of COVID‐19 has been greatly impacted by regulatory policies and behavior patterns that vary across counties, states, countries. Population‐level dynamics can generally be described using a set ordinary differential equations, but these deterministic equations are insufficient for modeling the observed case rates, which due to local testing reporting nonhomogeneous among individuals. To assess impact population mobility on COVID‐19, we have developed novel Bayesian time‐varying...
Tianjian Zhouab, Michael J. Danielsc* & Peter Müllerda Department of Public Health Sciences, The University Chicago, IL;; b Statistics and Data Texas at Austin, TX;; c Statistics, Florida, Gainesville, FL;; d Mathematics, TX
Clinical trials usually involve sequential patient entry. When designing a clinical trial, it is often desirable to include provision for interim analyses of accumulating data with the potential stopping trial early. We review Bayesian designs based on posterior probabilities, predictive and decision-theoretic frameworks. A pertinent question whether need be adjusted planning analyses. answer this from three perspectives: frequentist-oriented perspective, calibrated subjective perspective....
The high failure rate of rotator cuff repair surgeries is positively correlated with age, yet the biomechanical changes to tendons age have not been described. As such, we sought benchmark and characterize histopathological properties accompanying gene expression human as a function degeneration. All four from fresh cadaver shoulders underwent biomechanical, histopathological, analyses. Following availability, samples were grouped into Younger (i.e., less than 36 years n = 2 donors) Aged...
Most clinical trials involve the comparison of a new treatment to control arm (eg, standard care) and estimation effect. External data, including historical trial data real‐world observational are commonly available for arm. With proper statistical adjustments, borrowing information from external can potentially reduce mean squared errors effect estimates increase power detecting meaningful In this article, we propose use Bayesian additive regression trees (BART) incorporating into analysis...
Osteoporosis is an independent risk factor for failure after arthroscopic rotator cuff repair. Since rerupture rates repair are associated with decreased bone mineral density and microarchitecture, adaptations of biomechanical properties the enthesis in patients osteoporosis remain unclear. Additionally, effects osteogenic therapy carrier drugs used treatment on structure have not been previously documented.To investigate changes to soft tissue biomechanics insertional secondary without (ie,...
Tumor cell populations can be thought of as being composed homogeneous subpopulations, with each subpopulation characterized by overlapping sets single nucleotide variants (SNVs). Such subpopulations are known subclones and an important target for precision medicine. Reconstructing such from next-generation sequencing (NGS) data is one the major challenges in We present PairClone a new tool to implement this reconstruction. The main idea model short reads mapped pairs proximal SNVs. In...
We present TreeClone, a latent feature allocation model to reconstruct tumor subclones subject phylogenetic evolution that mimics evolution. Similar most current methods, we consider data from next-generation sequencing of DNA. Unlike methods use information in short reads mapped single nucleotide variants (SNVs), subclone phylogeny reconstruction using pairs two proximal SNVs can be by the same reads. As part Bayesian inference model, construct tree prior. The structure prior greatly...
<title>Abstract</title> <bold>Background</bold> Canine cognitive dysfunction (CCD) is a naturally occurring disease in aged dogs that shares many behavioural and pathological similarities with Alzheimer’s disease. There has been little research on vivo imaging of CCD, to the best our knowledge, no studies have investigated use diffusion tensor (DTI) visualize brain atrophy. The primary aim this study was determine applicability DTI for various regions canine brain. A secondary whether could...
Introduction With rapidly growing interest in the use of cannabidiol (CBD) management pain and other conditions, more information is needed on safety efficacy this supplement, particularly its co-administration with commonly used pharmaceuticals such as non-steroidal anti-inflammatory drugs (NSAIDs). This study sought to assess effect CBD dogs mobility impairments, well evaluate clinical tolerance together NSAIDs. Materials methods Forty-two client-owned diagnosed impairments were enrolled...