A5052301920- Advanced biosensing and bioanalysis techniques
- Analytical chemistry methods development
- Biosensors and Analytical Detection
- Mass Spectrometry Techniques and Applications
- Cancer-related molecular mechanisms research
- Pesticide Residue Analysis and Safety
- Geriatric Care and Nursing Homes
- Lung Cancer Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Oceanographic and Atmospheric Processes
- Coastal and Marine Dynamics
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Knee injuries and reconstruction techniques
- Luminescence and Fluorescent Materials
- Lung Cancer Research Studies
- Congenital Diaphragmatic Hernia Studies
- Sarcoma Diagnosis and Treatment
- Muscle activation and electromyography studies
- Cancer Immunotherapy and Biomarkers
- Tropical and Extratropical Cyclones Research
- Autophagy in Disease and Therapy
- Molecular Biology Techniques and Applications
- Polyamine Metabolism and Applications
Ottawa Hospital Research Institute
2023-2025
Ottawa Hospital
2023-2025
Xiangtan University
2020-2024
Second Affiliated Hospital of Zhejiang University
2014-2024
Capital Medical University
2021-2024
University of Ottawa
2022-2024
Bruyère
2024
China Rehabilitation Research Center
2021-2024
National Marine Data and Information Service
2017-2024
Southwest Forestry University
2024
Detection of C-reactive protein using nanoparticle-enhanced surface plasmon resonance an aptamer-antibody sandwich assay.
An idea drug carrier, with good binding affinity, selectivity, payload capacity, and cellular internalized capability, will greatly improve the efficiency of target delivery. Herein a self-assembled multivalent DNA nanostructure was developed as carrier for efficient targeted The structure similar to that centipede, composed trunk legs: scaffold via hybridization chain reaction (HCR) from two biotinylated hairpin monomers created upon initiation by trigger DNA, legs were aptamers conjugated...
Android malware and its variants are a major challenge for mobile platforms. However, there two main problems in the existing detection methods: <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</i> ) The method lacks evolution ability malware, which leads to low rate of model variants. xmlns:xlink="http://www.w3.org/1999/xlink">b</i> Traditional methods require centralized data training, however, aggregation training samples is limited due...
Transition metal dichalcogenides (TMDs) are quantum confined systems with interesting optoelectronic properties, governed by Coulomb interactions in the monolayer (1L) limit, where strongly bound excitons provide a sensitive probe for many-body interactions. Here, we use two-dimensional electronic spectroscopy (2DES) to investigate and their dynamics 1L-WS
Nucleic acids, as one kind of significant biomarker, have attracted tremendous attention and exhibited immense values in fundamental studies clinical applications. In this work, we developed a fluorescent assay for detecting nucleic acids complex samples based on magnetic microbead (MMB)-assisted catalyzed hairpin assembly (CHA) donor donor–acceptor fluorescence resonance energy transfer ("DD–A" FRET) signaling mechanism. Three types DNA probes were employed system, including Capture, H1...
Hmong–Mien (HM) -speaking populations, widely distributed in South China, the north of Thailand, Laos, and Vietnam, have experienced different settlement environments, dietary habits, pathogenic exposure. However, their specific biological adaptation remained largely uncharacterized, which is important population evolutionary genetics Trans-Omics for regional Precision Medicine. Besides, origin genetic diversity HM people phylogenetic relationship with surrounding modern ancient populations...
Ion mobility spectrometry (IMS) is a reliable and sensitive technique for the detection analysis of compounds at trace level. Depending on chemical composition sample, may be positively or negatively charged to form different polarity ions detected in positive negative electric field. In order detect multiple threats simultaneously with miniaturized devices, using single unit achieve high resolving power sensitivity important. this work, drift tube fast switching capabilities integrated...
The glioma microenvironment is critical for tumor growth, where reprogramming M2-polarized tumor-associated macrophages/microglia (TAMs) to an antitumor M1 phenotype represents a promising therapeutic strategy. While the potassium channel regulatory subunit KCNE3 has been implicated in tumorigenesis across malignancies, its functional role shaping remains undefined. Here, we leveraged transcriptome data from Gene Expression Omnibus (GEO) identify as TAM-enriched gene gliomas. To interrogate...
Self-assembly of small building blocks into functional supramolecular nanostructure has opened prospects for the design novel materials. With this molecular engineering strategy, we have developed self-assembled nanoprobes (SSNPs) ratiometric fluorescence measurement pH values in cells. The with a diameter ∼30 nm could be formulated just by mixing pH-sensitive adamantane-fluorescein (Ad-F) and pH-insensitive adamantane-Rhodamine B (Ad-R) β-cyclodextrin polymer (poly-β-CD) at one time. good...
We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The could be internalized by RAW264.7 cells and stimulate secretion large amounts cytokines, successively inducing effective apoptosis cancer cells.
Aging-related cognitive impairment (ARCI) is rapidly becoming a healthcare priority. However, there currently no excellent cure for it. Cognitive-exercise dual-task intervention (CEDI) promising method to improve ARCI, while the underlying mechanisms remain unclear. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in onset, development, rehabilitation of ARCI. This study aimed investigate effects CEDI role regulation lncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3β...
High incidence, severe consequences, unclear mechanism, and poor treatment effect happened in Parkinson's disease-related dysphagia. Repetitive transcranial magnetic stimulation is an effective for dysphagia disease. However, the therapeutic underlying mechanism of repetitive disease are still unknown. Neuroinflammation has been proven to be associated with disease, NLRP3 inflammasome activation pyroptosis common neuroinflammatory processes. Therefore, we compared swallowing quality,...
Identifying patients with non-small cell lung cancer (NSCLC) who are optimal candidates for immunotherapy is a cornerstone in clinical decision-making. The tumor immune microenvironment (TIME) intricately linked both the prognosis of malignancy and efficacy immunotherapeutic interventions. CD8+ T cells, more specifically, tissue-resident memory cells [CD8+ (TRM) cells] postulated to be pivotal orchestrating system's assault on cells. Nevertheless, accurate quantification infiltration-and by...
The antidepressant mechanism of acupuncture has not been fully elucidated recently. Thus, the objective present study is to investigate modulating neuroinflammation induced by high mobility group box-1 (HMGB1) in rats subjected chronic restraint stress (CRS). Forty-four male Sprague Dawley were randomly divided into control, model, escitalopram, and group. Except for control group, all exposed CRS 21 days continuously. Rats escitalopram a suspension saline. One hour before procedures, was...