A5056814484- Synthesis and Properties of Aromatic Compounds
- Organometallic Complex Synthesis and Catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Magnetism in coordination complexes
- Organoboron and organosilicon chemistry
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Ferrocene Chemistry and Applications
- Fullerene Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Boron and Carbon Nanomaterials Research
- Hydrogen Storage and Materials
- Photochemistry and Electron Transfer Studies
- Ammonia Synthesis and Nitrogen Reduction
- Machine Learning in Materials Science
- Advanced Photocatalysis Techniques
- Advanced NMR Techniques and Applications
- Photochromic and Fluorescence Chemistry
- Cancer Immunotherapy and Biomarkers
- Nuclear Structure and Function
- Axial and Atropisomeric Chirality Synthesis
- Autoimmune and Inflammatory Disorders Research
Southern Medical University
2022-2024
Zhejiang Cancer Hospital
2023-2024
Nanfang Hospital
2022-2024
University of Chinese Academy of Sciences
2023-2024
Xiamen University
2015-2023
Collaborative Innovation Center of Chemistry for Energy Materials
2015-2023
Second Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Qingdao Agricultural University
2021
Northwest Normal University
2014-2019
Abstract Antiaromatic species are substantially less thermodynamically stable than aromatic moieties. Herein, we report the stabilization of two classical antiaromatic frameworks, cyclobutadiene and pentalene, by introducing one metal fragment through first [2+2] cycloaddition reaction a late‐transition‐metal carbyne with alkynes. Experimental observations theoretical calculations reveal that decreases antiaromaticity in pentalene simultaneously, leading to air‐ moisture‐stable products....
The synthesis of small cyclic metal carbynes is challenging due to the large angle strain associated with highly distorted nonlinear triple bonds. Herein, we report a general route for five-membered carbyne complexes, osmapentalynes, by reactions an osmapentalene derivative allene, alkyne, and alkene. Experimental observations theoretical calculations document aromaticity in fused rings osmapentalynes. realization transforming osmapentalyne through this would not only allow further...
Abstract Polycyclic complexes containing a bridgehead transition metal are interesting species because the is shared by all rings simultaneously. In this study, we present novel osmium–bridgehead system with three fused five‐membered rings. This framework can be viewed as 10‐atom carbon chain coordinating to osmium center. sharp contrast nonplanar organic analogue, unique metallacycle exhibits good planarity, which was unambiguously verified means of X‐ray diffraction. Interestingly,...
Macrophages can transform into M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes, which mediate the immune/inflammatory response in rheumatoid arthritis (RA). Activated phenotype macrophages overexpression of folate (FA) receptors are abundant inflammatory synovium joints promote progression RA. Germacrone (GER) regulate T helper 1 cell (Th1)/the 2 (Th2) balance to delay arthritis. To deliver GER tissue cells reverse M1-type proinflammatory reduce inflammation, FA...
Hypoxia, as a main feature of the tumor microenvironment, has greatly limited efficacy photodynamic therapy (PDT), well its clinical application. Here, multifunctional composite nanoplatform, peptide/Ce6/MnO2 nanocomposite (RKCM), been constructed to alleviate hypoxia and increase PDT using rationally designed peptide fibrils encapsulate chlorin e6 (Ce6) inside mineralize MnO2 nanoparticles on surface. As result, RKCM significantly improved by increasing reactive oxygen species (ROS)...
As a fundamental chemical property, aromaticity guides the synthesis of novel structures and materials. Replacing carbon moieties aromatic hydrocarbons with transition metal fragments is promising strategy to synthesize intriguing organometallic counterparts similar their organic parents. However, since antiaromaticity will endow compound instability, it great challenge obtain an antiaromatic counterpart based on such replacement in hydrocarbons. Here, we report efficient transformation...
Antiaromaticity is extended from aromaticity as a complement to describe the unsaturated cyclic molecules with antiaromatic destabilization. To prepare species particularly challenging goal in synthetic chemistry because of thermodynamic instability such molecules. Among that, both Hückel and Möbius have been reported, whereas Craig one has not realized date. Here, we report first example planar species. Eight compounds were synthesized by deprotonation-induced reduction process fully...
Abstract Aromaticity, an old but still fantastic topic, has long attracted considerable interest of chemists. Generally, π aromaticity is described by π‐electron delocalization in closed circuits unsaturated compounds whereas σ‐electron saturated rings leads to σ aromaticity. Interestingly, our recent study shows that can be dominating three‐membered ring (3MR) cyclopropaosmapentalene. An interesting question raised: Can the aromaticity, which dominant 3MR, extended other...
Isolation of the simplest 4π three-membered heterocycles (1H-azirine, oxirene, thiirene, and selenirene) remains a big challenge due to their π-antiaromaticity significant ring strain. Here we demonstrate that incorporation transition-metal fragment could stabilize antiaromatic selenirene pentalene frameworks simultaneously by density functional theory (DFT) calculations. Experimental verification leads Se-containing metallapolycycles, osmapentaloselenirenes, with remarkable thermal...
Abstract Antiaromatic species are substantially less thermodynamically stable than aromatic moieties. Herein, we report the stabilization of two classical antiaromatic frameworks, cyclobutadiene and pentalene, by introducing one metal fragment through first [2+2] cycloaddition reaction a late‐transition‐metal carbyne with alkynes. Experimental observations theoretical calculations reveal that decreases antiaromaticity in pentalene simultaneously, leading to air‐ moisture‐stable products....
Abstract Background Cholestasis is a common yet severe complication that occurs during the advancement of liver metastasis. However, how cholestasis impacts development, treatment, and tumor microenvironment (TME) metastasis remains to be elucidated. Methods Extrahepatic intrahepatic cholestatic mouse models with were established detect differential expression levels genes, infiltration immune cells change in bile acid-associated metabolites by using RNA-Sequencing, flowcytometry, liquid...
A novel glycosyl hydrolase family 11 xylanase gene, xynMF13A, was cloned from Phoma sp. MF13, a xylanase-producing fungus isolated mangrove sediment. xynMF13A heterologously expressed in Pichia pastoris, and the recombinant XynMF13A (rXynMF13A) purified by Ni-affinity chromatography. The temperature pH optima of rXynMF13A were 45 °C 5.0, respectively. showed high level salt tolerance, with maximal enzyme activity being seen at 0.5 M NaCl as much 53% 4 NaCl. major hydrolysis products corncob...
Density functional theory (DFT) calculations reveal unexpected higher stabilisation of two classical anti-aromatic frameworks (cyclobutadiene and pentalene) achieved with a ruthenium fragment compared to the osmium couterpart.
The efficient and divergent construction of two types valuable N-heterocycle is achieved easily, with the first example generation α-oxo copper carbenes via copper-catalyzed oxidation non-polarized alkynes.
Abstract Aromaticity is one of the most fundamental and fascinating chemical topics, attracting both experimental theoretical chemists owing to its many manifestations. Both σ‐ π‐aromaticity can be classified depending on character cyclic electron delocalization. In general, σ‐aromaticity stabilizes fully saturated rings with σ‐electron delocalization whereas traditional describes π‐conjugation in unsaturated rings. Here, we demonstrate a strong correlation between nucleus‐independent shift...
Abstract The synthesis of small cyclic metal carbynes is challenging due to the large angle strain associated with highly distorted nonlinear triple bonds. Herein, we report a general route for five‐membered carbyne complexes, osmapentalynes, by reactions an osmapentalene derivative allene, alkyne, and alkene. Experimental observations theoretical calculations document aromaticity in fused rings osmapentalynes. realization transforming osmapentalyne through this would not only allow further...
The Clar structure of polybenzenoid hydrocarbons (PBHs) have attracted considerable interest both theoretical and experimental chemists since it was proposed in the 1950s. However, remains unclear whether could exist inorganic PBHs, boron nitride (BN) analogues where alternate nitrogen atoms are used to replace carbon PBHs. Here, we carry out thorough density functional theory (DFT) calculations probe possibility structures BN A strong correlation (r(2) =0.975) between ring number (n=3-10)...
A novel multi-domain high molecular xylanase coding gene (xynSL3) was cloned from Alkalibacterium sp. SL3, an alkaliphilic bacterial strain isolated the sediment of soda lake Dabusu. The deduced XynSL3 is composed a putative signal peptide, three tandem domains carbohydrate binding module (CBM) family 22, catalytic domain glycosyl hydrolase (GH) 10 and CBM9. shares highest identity 66% to hypothetical protein AK22 has low identities (33%-45%) with other functionally characterized xylanases....
Immunotherapy has significantly altered the treatment paradigm of non-small cell lung cancer (NSCLC), but not all patients experience durable benefits. Predictive biomarkers are needed to identify who may benefit from immunotherapy. We retrospectively collected tumor tissues 65 with advanced NSCLC before treatment, and performed transcriptomic genomic analysis. By performing single-sample gene set enrichment analysis, we constructed a predictor named IKCscore based on microenvironment...
Abstract Polycyclic complexes containing a bridgehead transition metal are interesting species because the is shared by all rings simultaneously. In this study, we present novel osmium–bridgehead system with three fused five‐membered rings. This framework can be viewed as 10‐atom carbon chain coordinating to osmium center. sharp contrast nonplanar organic analogue, unique metallacycle exhibits good planarity, which was unambiguously verified means of X‐ray diffraction. Interestingly,...
Transition-metal-containing metallaaromatics have attracted considerable interest from both experimental and computational chemists because they can display properties of organometallic compounds aromatic organic compounds. In general, the transition metal in a metallabicycle prefers nonbridged position to bridgehead one larger ring strain caused by rigidity position, as exemplified metallanaphthalene metallanaphthalyne. On contrary, osmium atoms recently synthesized osmapentalyne...
A series of dibenzo[a,f][1,3,5]triazino[2,1,6-cd] pyrrolizine compounds have been synthesized from phthalonitriles by a facile intramolecular cyclization process using "half-phthalocyanine" precursors, and they were characterized X-ray crystallography, 1 H NMR spectroscopy, UV/Vis, theoretical calculations. These spectroscopic profiles similar to phthalocyanines porphyrins, although their inner-core structures coordination types are totally different. They can be regarded as new class...