A5032537824- Bladder and Urothelial Cancer Treatments
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Alcohol Consumption and Health Effects
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Extracellular vesicles in disease
- Traumatic Ocular and Foreign Body Injuries
- Urinary Tract Infections Management
- Gut microbiota and health
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Cancer, Stress, Anesthesia, and Immune Response
Chinese University of Hong Kong
2009-2024
Prince of Wales Hospital
2021-2022
University of Hong Kong
2022
City University of Hong Kong
2022
Hong Kong Polytechnic University
2019
Cigarette smoke is one of the risk factors for gastric cancer and nicotine has been reported to promote tumor growth. Deregulation microRNA (miRNA) cyclooxygenase-2 (COX-2) expressions are hallmarks many cancers including cancer. Here, we used an miRNA array platform covering a panel 95 human miRNAs examine expression profile in nicotine-treated cells. We found that miR-16 miR-21 were upregulated upon stimulation, transfection with anti-miR-16 or anti-miR-21 significantly abrogated cell...
Emerging studies demonstrate that PIWI-interacting RNAs (piRNAs) are associated with various human cancers. This study aimed to evaluate the urinary extracellular vesicles (EVs) piRNAs as non-invasive biomarkers for prostate cancer (PCa) diagnosis. RNA was extracted from EVs five PCa patients and healthy controls (HC), were analyzed by small sequencing. Dysregulated identified then validated in another 30 10 HC reverse-transcription polymerase chain reaction (RT-qPCR). The expressions of...
Background: Retinoic acid-regulated nuclear matrix-associated protein (RAMP) is a WD40 repeat-containing that involved in various biological functions, but little known about its role human cancer. This study aims to delineate the oncogenic of RAMP gastric carcinogenesis. Methods: expression was examined by real-time quantitative RT-PCR, immunohistochemistry and western blotting. Inhibition performed siRNA-mediated knockdown. The functional effects on cell kinetics were measured viability...
Cyclooxoygenase (COX)-2 overexpression is involved in gastric carcinogenesis. While high-salt intake a known risk factor for cancer development, we determined the effects of high salt on chemical carcinogenesis COX-2 transgenic (TG) mice. TG mice were developed C57/BL6 strain using full-length human cox-2 complementary DNA construct. Six-week-old and wild-type (WT) littermates randomly allocated to receive alternate week N -methyl- -nitrosourea (MNU, 240 p.p.m.) drinking water or control 10...
Kidney cancer is a common urological malignancy worldwide with an increasing incidence in recent years. Among all subtypes, renal cell carcinoma (RCC) represents the most predominant kidney. Clinicians faced major challenge to select effective and suitable treatment regime for patients from wide range of modalities, despite improved understanding diagnosis RCC.
Prostate cancer is the most inheritable with approximately 42% of disease risk attributed to inherited factors by studies twins, indicating importance additional genetic screening identify predisposition variants. However, only DNA damage repair (DDR) genes have been investigated thoroughly in prostate cancer. To determine comprehensive germline mutation landscape Chinese patients, we performed whole exome sequencing 100 Han patients Hong Kong and identified deleterious mutations. A total 36...
In this study we assessed the effects of a ramping protocol in patients undergoing extracorporeal shock wave lithotripsy renal stones.In prospective with stones were randomized to receive delivered using group 1 (first 1,000 shocks at energy level 5 followed by 6 and final 7) fixed voltage 2 (all 3,000 7). Treatment was administered Modulith® SLX-F2. The primary outcome treatment success 12 weeks after single session, defined as lack stone or less than 4 mm fragment on computerized...
Urinary bladder cancer is a common worldwide. Currently, the modality of treating and monitoring wide. Nonetheless, high recurrence rate non-muscle-invasive after surgical resection still unsatisfactory. Hereby, our study demonstrated whether intra-operative post-operative environments will affect utilizing in vitro cell line model. Bladder lines were submerged four different irrigating fluids for assessing their tumorigenic properties. Our results showed that sterile water performed best...
Abstract Introduction Androgen deprivation therapy (ADT) is a key treatment modality in the management of prostate cancer (PCa), especially for patients with metastatic disease. Increasing evidences suggest that who received ADT have increased incidence diabetes, myocardial infarction, stroke, and even mortality. It important to understand pathophysiological mechanisms on how increases cardiovascular risk induces events, which would provide information potential implementation preventive...
Bladder cancer (CaB) has a high recurrence rate despite surgery. As bladder is constantly filled with urine, it worthwhile to investigate whether could have any detrimental effects on cells.We investigated the cytotoxicity of urine samples from CaB patients and normal controls four cell lines tested percentage death, proliferation, adhesion, invasion colonies formation ability. In order identify potential components involving in cytotoxicity, we evaluated some basic physiochemical parameters...
Abstract Purpose Urine proteome is a valuable reservoir of biomarkers for disease diagnosis and monitoring. Following formation as the plasma filtrate in kidney, urine progressively modified by active reabsorption secretion urinary tract. However, little known about how changes it passes along Experimental design To investigate this, we compared composition renal pelvis (RPU) individually self‐voided bladder (BU) collected from seven unilateral tract obstruction male patients LC‐MS/MS...
Abstract Urine proteome is a valuable reservoir of biomarkers for disease diagnosis and monitoring. Following its formation as the plasma filtrate in kidney, urine progressively modified by active reabsorption secretion cells lining urinary tract. However, little known about how changes it passes along To investigate this, we compared composition renal pelvis (RPU) individually self-voided bladder (BU) collected from 7 one-side tract obstruction male patients. While no exclusive proteins...
Abstract Urinary bladder cancer is a common worldwide. Currently, the modality of treating and monitoring wide. Nonetheless, high recurrence rate non-muscle-invasive after surgical resection still unsatisfactory. Hereby, our study demonstrated whether intra-operative post-operative environments will affect utilizing in vitro cell line model. Bladder lines were submerged four different irrigating fluids for assessing their tumorigenic properties. Our results showed that sterile water...