A5104297994- Ophthalmology and Visual Health Research
- Stroke Rehabilitation and Recovery
- Semiconductor materials and devices
- GaN-based semiconductor devices and materials
- Acute Lymphoblastic Leukemia research
- Emotional Intelligence and Performance
- Digestive system and related health
- Diet, Metabolism, and Disease
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Infant Nutrition and Health
- Gut microbiota and health
- Glutathione Transferases and Polymorphisms
- Semiconductor materials and interfaces
- Lung Cancer Research Studies
- Health and Well-being Studies
Usmanu Danfodiyo University Teaching Hospital, Sokoto
2024
Kunming Medical University
2015
Abstract As a key component of the B-cell receptor (BCR) signaling complex, Bruton’s tyrosine kinase (BTK) plays an essential role in malignancies via both and non-kinase functions. This was revealed by early genetic studies emerging kinase-impaired mutations, which activate BCR intricate protein-protein interactions, conferring resistance to range covalent or non-covalent BTK inhibitors (BTKi). Therefore, new targeting strategy is urgently needed for patients who acquired mutations BTK....
Abstract Oncogenic mutations of the receptor tyrosine kinase KIT drive cancers such as gastrointestinal stroma tumors (GIST) and systemic mastocytosis (SM). The in juxtamembrane domain (Exon 11, E11) extracellular (E9) are most commonly found GIST, A-Loop D816V mutation (E17) over 90% SM cases. Currently approved inhibitors either lacked efficacy against certain mutants, like imatinib, or selectivity multi-kinase targeting sunitinib regorafenib. Primary acquired resistance intolerance is...
This study aimed to identify the oncogenes associated with lung cancer based on mRNA and single nucleotide polymorphism (SNP) profile data. The expression data of GSE43458 (80 30 normal samples) SNP GSE33355 (61 pairs samples control were downloaded from Gene Expression Omnibus database. Common genes between identified as oncogenes. Risk subpathways selected locus analyzed using iSubpathwayMiner package in R. Moreover, protein-protein interaction (PPI) network was constructed HPRD database...
Background: Post Stroke Depression (PSD) occurs in a significant number of patients and constitutes an important complication stroke, leading to greater disability as well increased mortality. This study examined depressive symptoms among post stroke attending neurology clinic tertiary hospital Northwest Nigeria. Methods: cross-sectional was carried out 83 survivors. Participants were administered socio-demographic, clinical characteristics pro-forma questionnaire depression subscale the...
Background: Despite an increase in the overall number of medical students, shortage psychiatry trainees Nigeria and worldwide reflects diminishing interest among students. The study examined degree factors influencing attraction towards as a career choice. Method: A cross-sectional 71 final-year students who enrolled at Usmanu Danfodiyo University Sokoto State (UDUS), Northwest between 2006/07 2013/14 academic session were interviewed 2021 while 600 level. questionnaires adapted from similar...
Abstract In this study, we investigated the impact of single stress (negative gate bias stress) and combined (both negative drain voltage on instability threshold (V TH ) p-GaN HEMT devices during dynamic switching operation. The V shift pulsed was for first time. exhibits an initial rapid increase upon initiation a slight decrease with increasing For applied stresses GS = −1/−2/−3 V, values were, respectively, 0.12/0.16/0.19 at time 100 s. Under −3 DS value 0.61 V. After stress, saturation...