A5101505850- Laser Material Processing Techniques
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Plant nutrient uptake and metabolism
- Chronic Myeloid Leukemia Treatments
- Click Chemistry and Applications
- Plant Molecular Biology Research
- Advanced Neuroimaging Techniques and Applications
- Advanced Fiber Laser Technologies
- Surface Treatment and Residual Stress
- HER2/EGFR in Cancer Research
- Melanoma and MAPK Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Soil Carbon and Nitrogen Dynamics
- Cutaneous Melanoma Detection and Management
- Fungal Biology and Applications
- Congenital Heart Disease Studies
- RNA regulation and disease
- Stroke Rehabilitation and Recovery
- Forest Ecology and Biodiversity Studies
- Fern and Epiphyte Biology
- Facial Nerve Paralysis Treatment and Research
- Seedling growth and survival studies
- Flowering Plant Growth and Cultivation
- Aortic Disease and Treatment Approaches
State Forestry and Grassland Administration
2022-2024
Fujian Agriculture and Forestry University
2022-2024
University of Oxford
2012-2024
Ludwig Cancer Research
2018
Shanghai Institute of Optics and Fine Mechanics
2017
Chinese Academy of Sciences
2017
University of Chinese Academy of Sciences
2017
Beijing Institute of Petrochemical Technology
2007
Abstract How cells coordinate the response to fluctuating carbon and nitrogen availability required maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation nuclear translocation of Transcription Factor EB (TFEB), transcriptional regulator lysosome biogenesis autophagy deregulated in cancer neurodegeneration. Beyond its cytoplasmic sequestration, how TFEB phosphorylation regulates nuclear-cytoplasmic shuttling, whether can amino...
The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much development is deregulated in cancer. In principle, combinatorial posttranslational modification key lineage-specific transcription factors would be an effective means to integrate critical events. Understanding how this might achieved central deciphering impact microenvironmental cues disease. microphthalmia-associated factor MITF plays a crucial role melanocytes, retinal pigment epithelium, osteoclasts, mast...
Abstract As a key component of the B-cell receptor (BCR) signaling complex, Bruton’s tyrosine kinase (BTK) plays an essential role in malignancies via both and non-kinase functions. This was revealed by early genetic studies emerging kinase-impaired mutations, which activate BCR intricate protein-protein interactions, conferring resistance to range covalent or non-covalent BTK inhibitors (BTKi). Therefore, new targeting strategy is urgently needed for patients who acquired mutations BTK....
Abstract Oncogenic mutations of the receptor tyrosine kinase KIT drive cancers such as gastrointestinal stroma tumors (GIST) and systemic mastocytosis (SM). The in juxtamembrane domain (Exon 11, E11) extracellular (E9) are most commonly found GIST, A-Loop D816V mutation (E17) over 90% SM cases. Currently approved inhibitors either lacked efficacy against certain mutants, like imatinib, or selectivity multi-kinase targeting sunitinib regorafenib. Primary acquired resistance intolerance is...
The continuous establishment of Chinese fir (
The root is the main organ of a plant for absorbing resources and whose spatial distribution characteristics play an important role in survival seedlings after afforestation. Chinese fir (Cunninghamia lanceolata) one China’s most plantation species. To clarify effects propagation methods on growth trees, sampled trees cultivated by seed germination, tissue culture, asexual cutting were taken as research objects. morphology, geometric configuration, different analyzed. influence morphology...
Within cells multiple related transcription factors targeting the same sequences may co-exist, leading to potential regulatory cooperativity, redundancy or competition. Yet differential roles and biological functions of co-targeting is poorly understood. In melanoma, three highly-related are co-expressed: The mTORC1-regulated TFEB TFE3, that key effectors a wide range metabolic microenvironmental cues; MITF, controls melanoma phenotypic identity. Here we reveal functional specialization TFE3...
In this study, two kinds of Au-coated gratings (ACGs) with a period 1740 lines/mm were fabricated and evaluated. For these ACG samples, magnetron sputtering e-beam evaporation used as the gold deposition process, samples had bandwidth at least 170 nm, -1st-order diffraction efficiency exceeding 90% around center wavelength 800 nm. The one-on-one damage threshold ACGs by measured pulse width 60 fs was 0.59 J/cm2 0.43 in case beam normal fluence, respectively. typical morphology former type...
Abstract Phosphorous (P) is a crucial limiting nutrient for plant growth and development in terrestrial ecosystems. As one of the most important subtropical coniferous tree species, Chinese fir (Cunninghamia lanceolata) plays major role timber supply, climate mitigation forest recreation. In this study, two clones (020 061) with high rate were subjected to levels P supply greenhouse pot experiment: P-deficient P0 (no supply) P-replete P1 (1.0 mmol L−1 KH2PO4). Our objectives study...
Fine root traits and their relationships reflect the ecological trade-off strategies of plants in resource investment are important for understanding life growth response to changes environment. We used 16-year-old Chinese fir (Cunninghamia lanceolata Lamb. Hook.) plantations with different slope positions as research object explore morphological, anatomical, chemical properties fine roots relationships. With increasing order levels, at showed similar change trends; however, same level,...
<h3>Background</h3> White matter changes (WMC) on CT or MR brain imaging are common in TIA and stroke patients. Inconsistent associations, never so far researched population-based cohorts, have been reported between WMC severity of stroke, disability, risk recurrent death. <h3>Methods</h3> In consecutive patients, semi-quantitatively rated MRI, were related to premorbid disability (modified Rankin Score—mRS), baseline MMSE, at 1 year death during follow-up. Logistic Cox regression analyses...
Introduction The longitudinal section cell morphology of Chinese fir roots was studied to better understand the relationship between root structure and function. Materials In this study, adjusted microwave paraffin method selected two sample transparency methods were used process combined with laser scanning confocal microscopy (LSCM) technique, can be clearly observed in a short time. At same time, observation effect LSCM image thick ordinary optical imaging thin analyzed compared. Results...
<h3>Background</h3> White matter changes (WMC) on brain imaging increase with age. The association hypertension, their risk factor, has been found weaker in the elderly, perhaps because use of only a single baseline or limited number recent blood pressure (BP) measurements does not reflect longer-term hypertension. fall diastolic BP elderly may also exacerbate WMC. We determined based all measures over 10-years. <h3>Methods</h3> In stroke and TIA cohort, we collected pre-morbid BPs from...
<h3>Background</h3> White matter changes (WMC) on brain imaging, reflecting chronic subcortical ischaemia, increase steeply with age. Hypertension is a risk factor for WMC, particularly in younger patients, and variability blood pressure (BP) acute stroke. However, the relative contribution of long-term mean BP versus to development WMC uncertain. We determined these associations based all measures over 10-year period. <h3>Methods</h3> In consecutive TIA or stroke we collected pre-morbid BPs...
<h3>Background</h3> Occult atheroma has often been suggested to be the potential aetiology of undetermined ischaemic stroke. If so, we hypothesised that risk factor profile stroke should resemble large-vessel <h3>Methods</h3> We compared subtypes (TOAST classification) in a population-based study TIA and included these data meta-analysis associations all published population—and hospital-based studies. <h3>Results</h3> Risk our were broadly similar those nine other Although 24 studies more...
<h3>Background</h3> The Face Arm Speech Test (FAST) is used in public education to help people recognise stroke symptoms. It was designed identify major stroke, however it uncertain how well the test identifies those with TIA and minor whom acute prevention required. <h3>Methods</h3> In a population-based study, we categorised consecutive patients (minor stroke=NIHSS≤5) using FAST relation delay seeking medical attention early recurrent risk. <h3>Results</h3> Of 2183 (1000 TIA,775 stroke,408...