A5068049640- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Global Cancer Incidence and Screening
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Air Quality and Health Impacts
- Pulmonary Hypertension Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Vascular Anomalies and Treatments
- CAR-T cell therapy research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Glycogen Storage Diseases and Myoclonus
- Histone Deacetylase Inhibitors Research
- Transplantation: Methods and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Ocular and Laser Science Research
Ospedale G.B. Morgagni - L.Pierantoni
2022-2024
University of Bologna
2023-2024
University of Oxford
2024
William Osler Health System
2021-2024
Vita-Salute San Raffaele University
1995-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023
University of Padua
2017-2021
Brampton Civic Hospital
2021
European Institute of Oncology
2019-2020
As part of the APHEA project this study examined association between airborne particles and hospital admissions for cardiac causes (ICD9 390-429) in eight European cities (Barcelona, Birmingham, London, Milan, Netherlands, Paris, Rome, Stockholm). All were studied, as well stratified by age. The ischaemic heart disease 410-413) stroke 430-438) was also age.Autoregressive Poisson models used that controlled long term trend, season, influenza epidemics, meteorology to assess short-term effects...
Epidermal growth factor receptor (EGFR) overexpression is associated with the development of head and neck cancer (HNC) represents one main therapeutic targets for this disease. The use EGFR inhibitors has limited efficacy due to their primary acquired resistance, partially because increased epithelial mesenchymal transition (EMT). HDAC inhibitor SAHA been shown revert EMT in different tumours, including HNC. In study, we investigated cooperative role tyrosine kinase gefitinib both...
To date, there have been no established therapies for recurrent malignant pleural mesothelioma (MPM) after multimodality treatment. Aims of this retrospective study are to analyze the recurrence pattern, its treatment and identify predictors best oncological outcomes relapsed MPM, comparing extrapleural pneumonectomy (EPP) vs. pleurectomy/decortication (PD). Study population: 94 patients with MPM underwent macroscopic complete resection (52.1% EPP 47.9% PD) between July 1994 February 2020....
P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role outcome of head neck cancer. Many studies been conducted assess possible use p63 as prognostic marker squamous cell carcinoma cancers, but results are still not well defined. Moreover, clear relationship between expression presence high-risk HPV E6 E7 oncoproteins has delineated. Here we describe how is mostly HPV-positive compared HPV-negative cancer lines, with very good correlation mRNA protein levels.
Within cells multiple related transcription factors targeting the same sequences may co-exist, leading to potential regulatory cooperativity, redundancy or competition. Yet differential roles and biological functions of co-targeting is poorly understood. In melanoma, three highly-related are co-expressed: The mTORC1-regulated TFEB TFE3, that key effectors a wide range metabolic microenvironmental cues; MITF, controls melanoma phenotypic identity. Here we reveal functional specialization TFE3...
Gold standard therapy for solitary fibrous tumour of the pleura is complete surgical resection. Aims this retrospective study are to evaluate oncological and outcomes verify clinical reliability prognostic scores presented in literature.Study population: 107 patients surgically treated between 1972 2018. Male/female ratio: 1/2.45; median age at surgery: 60 years (range, 19-80); peduncle lesions 69.8%; visceral origin 72.9%; benign histology 73.8%; diameter 8 cm (range 1 35, 27 cases giant...
Abstract Background Respiratory muscle strength affects pulmonary function after lung resection; however, the role of diaphragm density, an emerging index quality, remains unexplored. We investigated crural density (CDD) in respiratory complications (RC) video-assisted thoracoscopic surgery (VATS) lobectomy for cancer. Methods A total 118 patients were retrospectively enrolled between 2015 and 2022. Exclusion criteria neoadjuvant therapy, thoracic trauma, previous cardiothoracic abdominal...
Five sessions presented at the European Respiratory Society Congress 2023 were selected by Assembly 8, consisting of thoracic surgeons and lung transplant professionals. Highlights covering management adult spontaneous pneumothorax, malignant pleural effusion, infectious immune-mediated complications after transplantation, as well pro con debate on age limit in transplantation results ScanCLAD study summarised early career members, supervised assembly faculty.
Preoperative identification of unresectable pleural mesothelioma could spare unnecessary surgical intervention and accelerate the initiation medical treatments. The aim this study is to determine predictors unresectability, testing our impression that contraction ipsilateral hemithorax often associated with exploratory thoracotomy. Between 1994 2020, 291 patients undergoing intended macroscopic complete resection for after chemotherapy were retrospectively investigated. Eligible (n = 58)...
Background: Primary malignant chest wall tumors (PMCWTs) are a rare heterogeneous group of neoplasms arising from bones and soft tissues the thorax. The gold standard treatment is surgical resection. In case wide defects, there two possibilities reconstruction: prosthetic or biological mesh and/or tissue flaps. aim this study to analyze different factors concurring outcome patients with PMCWTs surgically treated in our Institution. Methods: Retrospective 52 for 1982 2019. Survival,...
Background: Stage T4 non-small cell lung cancer (NSCLC) includes a heterogeneous group of locally advanced tumours.The role surgery in these cases is still under debate.The aims this retrospective study are to analyse oncological and surgical outcomes examine prognostic factors affecting survival T4-NCSLC invading great vessels or heart.Methods: Data 108 T4-NSCLC surgically treated patients at our Institution from 1990 2019, were retrospectively collected, focusing on demographics,...
Abstract Extracorporeal life support (ECLS) is an effective method for bridging patients to recovery in cases of respiratory and/or cardiac failure that are potentially reversible and unresponsive conventional management. Nevertheless, there have been only few reports about the use ECLS oncological with complications due their neoplasm or its treatment. We report veno-arterial extracorporeal membrane oxygenation three severe perioperative following surgery mesothelioma after induction...
Abstract: The proportion of octogenarian patients is growing over years. Nowadays video-assisted thoracoscopic surgery (VATS) permits to treat old age patients, even with limited pulmonary function, not otherwise suitable for surgery. aim our study analyse the factors influencing short and long terms outcome underwent VATS lobectomy. Between January 2013 March 2019 we performed 292 lobectomies which 26 were octogenarian. patients’ population divided in two groups according patient’s (group...