A5101967376- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related cognitive impairment studies
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Photoacoustic and Ultrasonic Imaging
- MicroRNA in disease regulation
- Ultrasound Imaging and Elastography
- Cancer, Lipids, and Metabolism
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Plant biochemistry and biosynthesis
- Microbial Community Ecology and Physiology
- Medical Imaging Techniques and Applications
- Chromatin Remodeling and Cancer
- Immunotherapy and Immune Responses
- Plant responses to water stress
Peking Union Medical College Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Nanjing University
2023-2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Anyang Tumor Hospital
2024
Rubber Research Institute
2007-2023
Chinese Academy of Tropical Agricultural Sciences
2007-2023
Nanjing Medical University
2023
Chinese Anti-Cancer Association
2022
Ministry of Agriculture and Rural Affairs
2020
Abstract Glioblastoma (GBM) is the most malignant and lethal intracranial tumor, with extremely limited treatment options. Immunotherapy has been widely studied in GBM, but none can significantly prolong overall survival (OS) of patients without selection. Considering that GBM cancer stem cells (CSCs) play a non-negligible role tumorigenesis chemoradiotherapy resistance, we proposed novel stemness-based classification screened out certain population more responsive to immunotherapy. The...
Abstract Background Brain metastasis (BM) is the most common intracranial malignancy causing significant mortality, and lung cancer origin of BM. However, cellular origins drivers BM from adenocarcinoma (LUAD) have yet to be defined. Methods The constitutions were characterized by single-cell transcriptomic profiles 11 LUAD primary tumor (PT) 10 samples (GSE131907). Copy number variation (CNV) clonality analysis applied illustrate tumors. metastasis-associated epithelial cells (BMAECs)...
Glioblastoma (GBM), the most lethal primary brain malignancy, is divided into histological (hist-GBM) and molecular (mol-GBM) subtypes according to 2021 World Health Organization classification of central nervous system tumors. This study aimed characterize clinical, radiological, molecular, survival features GBM under current scheme explore determinants.We re-examined genetic alterations IDH-wildtype diffuse gliomas at our institute from 2011 2022, enrolled GBMs for analysis after...
The optimal treatment of recurrent glioblastoma (GBM) remains controversial. Therefore, our study aimed to compare and rank active therapies in GBM. We performed a systematic review Bayesian network meta-analysis. obtained hierarchy using the surface under cumulative ranking curve mean ranks. A cluster analysis was conducted aggregate separated results three outcomes. protocol registered PROSPERO (CRD42019146794). total 1,667 citations were identified, 15 eligible articles with 17 treatments...
Background The 5th edition of the World Health Organization (WHO) classification central nervous system tumors incorporated specific molecular alterations into categorization gliomas. major revision scheme effectuates significant changes in diagnosis and management glioma. This study aimed to depict clinical, molecular, prognostic characteristics glioma its subtypes according current WHO classification. Methods Patients who underwent surgery for at Peking Union Medical College Hospital...
The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter has emerged as a favorable independent prognostic and predictive biomarker in glioma. This study aimed to build radiomics signature based on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for noninvasive measurement MGMT glioma.One hundred seven pathology-confirmed primary diffuse glioma patients were retrospectively included randomly assigned (n = 71) or validation cohort 36). was measured...
Background The 2021 World Health Organization Classification of Central Nervous System Tumors updates glioma subtyping and grading system, incorporates EGFR amplification (Amp) as one diagnostic markers for glioblastoma (GBM). Purpose This study aimed to describe the frequency, clinical value molecular correlation Amp in diffuse gliomas based on latest classification. Methods We reviewed patients between 2011 2022 at our hospital, included 187 adult with available tumor tissue detection...
The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis. Given the changes entities included each subtype under new classification, this research investigated distribution, prognostic value, and correlations with other alterations TERTp different subgroups latest classification. All patients admitted to Peking Union Medical College Hospital...
Abstract Background IDH-mutant astrocytoma and oligodendroglioma have an indolent natural history are recognized as distinct entities of neoplasms. There is little knowledge on the molecular differences between grade 2. Therefore, we investigated multiomics clinical data regarding these two types tumors. Method In silico analyses were performed around mRNA, somatic mutations, copy number alternations (CNAs), DNA methylation, microRNA (miRNA), epigenetics, immune microenvironment...
Gliomas are infiltrative neoplasms with a highly invasive nature. Due to its distinct genomic, genetic and epigenetic features, the immune prognostic signature (IPS) microenvironment of glioblastoma (GBM) merit further research. We aimed explore prognosis-related genes develop an IPS model for predicting prognosis in GBM. RNA-sequencing data, as well clinical information, from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) public cohorts were analyzed. To IPS, least absolute shrinkage...
Glioblastoma (GBM) is the most common primary malignant intracranial tumor with a poor prognosis. Ferroptosis newly discovered, iron-dependent, regulated cell death, and recent studies suggest its close correlation to GBM. The transcriptome clinical data were obtained for patients diagnosed GBM from TCGA, GEO, CGGA. Ferroptosis-related genes identified, risk score model was constructed using Lasso regression analyses. Survival evaluated by univariate or multivariate Cox regressions...
The World Health Organization (WHO) CNS5 classification system highlights the significance of molecular biomarkers in providing meaningful prognostic and therapeutic information for gliomas. However, predicting individual patient survival remains challenging due to lack integrated quantitative assessment tools. In this study, we aimed design a WHO CNS5-related risk signature predict overall (OS) rate glioma patients using machine learning algorithms.We extracted data from who underwent an...
The latest fifth edition of the World Health Organization (WHO) classification central nervous system (CNS) tumors (WHO CNS 5 classification) released in 2021 defined astrocytoma, IDH-mutant, Grade 4. However, understanding this subtype is still limited. We conducted study to describe features 4 and explored similarities differences between histological molecular subtypes.Patients who underwent surgery from January 2011 2022, classified as were included study. Clinical, radiological,...
Abstract Background To investigate whether the intraoperative superb microvascular imaging(SMI) technique helps evaluate lesion boundaries compared with conventional grayscale ultrasound in brain tumor surgery and to explore factors that may be associated complete radiographic resection. Methods This study enrolled 57 consecutive patients undergoing surgery. During operation, B-mode SMI evaluated of tumors. MRI before within 48h after was used as gold standard gross-total resection(GTR). The...
The immunosuppressive mechanisms of the surrounding microenvironment and distinct immunogenomic features in glioblastoma (GBM) have not been elucidated to date. To fill this gap, useful data were extracted from Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), GSE16011, GSE43378, GSE23806, GSE12907. With ssGSEA method ESTIMATE CIBERSORT algorithms, four microenvironmental signatures used identify glioma genes, samples reasonably classified into three immune phenotypes. molecular clinical...
Smoking food tobacco material include flue-cured leaves, expanded stems, and reconstituted sheets. As the main raw in cigarette industry, quality of leaves is very important to smoking products. The effects different combined moistening redrying treatments on physicochemical sensory changes have been systemically studied. This work has demonstrated that steam low-temperature slow (SM–LTSR) processes can improve moisture content color uniformity (p < 0.05). More importantly, degradation...