A5072561674- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Cancer-related cognitive impairment studies
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Pituitary Gland Disorders and Treatments
- Nosocomial Infections in ICU
- Musculoskeletal pain and rehabilitation
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Tuberous Sclerosis Complex Research
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Chromatin Remodeling and Cancer
- Hemodynamic Monitoring and Therapy
Peking Union Medical College Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Tsinghua University
2022-2024
UPMC Hillman Cancer Center
2022-2023
Beijing Tsinghua Chang Gung Hospital
2023
Creative Commons
2023
University of Pittsburgh Medical Center
2022
University of Pittsburgh
2022
Glioblastoma (GBM), the most lethal primary brain malignancy, is divided into histological (hist-GBM) and molecular (mol-GBM) subtypes according to 2021 World Health Organization classification of central nervous system tumors. This study aimed characterize clinical, radiological, molecular, survival features GBM under current scheme explore determinants.We re-examined genetic alterations IDH-wildtype diffuse gliomas at our institute from 2011 2022, enrolled GBMs for analysis after...
Background The 5th edition of the World Health Organization (WHO) classification central nervous system tumors incorporated specific molecular alterations into categorization gliomas. major revision scheme effectuates significant changes in diagnosis and management glioma. This study aimed to depict clinical, molecular, prognostic characteristics glioma its subtypes according current WHO classification. Methods Patients who underwent surgery for at Peking Union Medical College Hospital...
The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis. Given the changes entities included each subtype under new classification, this research investigated distribution, prognostic value, and correlations with other alterations TERTp different subgroups latest classification. All patients admitted to Peking Union Medical College Hospital...
Background The 2021 World Health Organization Classification of Central Nervous System Tumors updates glioma subtyping and grading system, incorporates EGFR amplification (Amp) as one diagnostic markers for glioblastoma (GBM). Purpose This study aimed to describe the frequency, clinical value molecular correlation Amp in diffuse gliomas based on latest classification. Methods We reviewed patients between 2011 2022 at our hospital, included 187 adult with available tumor tissue detection...
The latest fifth edition of the World Health Organization (WHO) classification central nervous system (CNS) tumors (WHO CNS 5 classification) released in 2021 defined astrocytoma, IDH-mutant, Grade 4. However, understanding this subtype is still limited. We conducted study to describe features 4 and explored similarities differences between histological molecular subtypes.Patients who underwent surgery from January 2011 2022, classified as were included study. Clinical, radiological,...
Abstract Background Spinal cord stimulation (SCS) is a surgical technique used in patients with chronic intractable pain, and its effectiveness safety have been validated by multiple studies. However, to maintain an optimal steady long-term effect still challenging. Here, we report new management paradigm integrating smartphone application remote programming. Chronic pain SCS implants can monitor their status on the phone change parameters accordingly. The PreMaSy study randomized controlled...
Abstract Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study to investigate relationship between preoperative cognitive function and clinical as well molecular factors, firstly based on new 2021 World Health Organization’s updated classification central nervous system tumors. A total 110 glioma enrolled underwent assessments using Mini-Mental State Examination Montreal Assessment. Clinical information was collected from medical records,...
Abstract Background Intratumoral hemorrhage, though less common, could be the first clinical manifestation of glioma and is detectable via MRI; however, its exact impacts on patient outcomes remain unclear controversial. The 2021 WHO CNS 5 classification emphasised genetic molecular features, initiating necessity to establish correlation between hemorrhage alterations. This study aims determine prevalence intratumoral in subtypes identify associated characteristics improve management....
Abstract Background The diagnosis of glioma has advanced since the release WHO 2021 classification with more molecular alterations involved in integrated diagnostic pathways. Our study aimed to present our experience clinical features and management astrocytoma, IDH mutant based on latest classification. Methods Patients diagnosed IDH‐mutant 5th edition CNS tumors at center from January 2009 2022 were included. divided into 2–3 grade group 4 group. Integrate diagnoses retrospectively...
SARS-CoV-2 NSP12, the viral RNA-dependent RNA polymerase (RdRp), is required for replication and a therapeutic target to treat COVID-19. To facilitate research on NSP12 protein, we developed rat monoclonal antibody (CM12.1) against N-terminus that can functional studies. Immunoblotting immunofluorescence assay (IFA) confirmed specific detection of protein by this cells overexpressing protein. Although generated from ORF1ab polyprotein, IFA human autopsy COVID-19 lung samples revealed...
The fifth edition of the World Health Organization (WHO) classification central nervous system (CNS) tumors released in 2021 formally defines pediatric-type diffuse gliomas. However, there is still little understanding gliomas, and even less attention has been paid to adult patients. Therefore, this study describes clinical radiological, survival, molecular features patients with glioma.Adult who underwent surgery from January 2011 2022, classified as glioma, were included study. Clinical,...
Purpose: To evaluate significant risk variables for sepsis incidence and develop a predictive model rapid screening diagnosis of in patients from the emergency department (ED). Methods: Sepsis-related were screened based on PIRO (Predisposition, Insult, Response, Organ dysfunction) system. Training (n = 1,272) external validation 568) datasets collected Peking Union Medical College Hospital (PUMCH) Beijing Tsinghua Changgung (BTCH), respectively. Variables at time admission. Sepsis...
Abstract Predictive markers and prognostic models are useful for the individualization of cancer treatment. In this study, we sought to identify clinical molecular factors predict overall survival in recurrent glioma patients receiving bevacizumab-containing regimens. A cohort 102 was retrospectively collected from June 2011 January 2022 at our institution. nomogram generated by Cox regression feature selection algorithms based on 19 clinicopathological 60 variables. The model's performance...
4E-BP1 is a tumor suppressor regulating cap-dependent translation that in turn controlled by mechanistic target of rapamycin (mTOR) or cyclin-dependent kinase 1 (CDK1) phosphorylation. serine 82 (S82) phosphorylated CDK1, but not mTOR, and the consequences this mitosis-specific phosphorylation are unknown. Knock-in mice were generated with single S82 alanine (S82A) substitution leaving other sites intact. S82A fertile exhibited no gross developmental behavioral abnormalities, homozygotes...
Abstract Purpose: The diagnosis of glioma has got an advance since the WHO 2021 classification published with more molecular alternations involved in integrate diagnoses pathways. Our study was aimed to show our experience on clinical features and management astrocytoma, IDH-mutant based latest classification. Methods: Patients diagnosed 5th edition CNS tumors at center from Jan 2009 2022 were included, divided 2-3 grade group 4 group. Integrate according 2016 confirmed retrospectively....
Abstract Purpose Cognitive impairment is a common feature among patients with diffuse glioma. This study aimed to investigate the relationship between cognitive function and clinical molecular factors under new 2021 WHO classification of tumors central nervous system (CNS 5). Methods A total 110 glioma were enrolled underwent preoperative assessments using Mini-Mental State Examination (MMSE) Montreal Assessment (MoCA). Clinical information was collected from medical records, gene sequencing...