A5100336641- Sepsis Diagnosis and Treatment
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Immune Response and Inflammation
- Hemodynamic Monitoring and Therapy
- Inflammasome and immune disorders
- Plant Reproductive Biology
- Catalytic Cross-Coupling Reactions
- Plant Virus Research Studies
- Plant and animal studies
- Synthesis and Catalytic Reactions
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Ferroptosis and cancer prognosis
- Catalysis for Biomass Conversion
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ultrasound and Hyperthermia Applications
- Per- and polyfluoroalkyl substances research
- Eicosanoids and Hypertension Pharmacology
- Sphingolipid Metabolism and Signaling
- Angiogenesis and VEGF in Cancer
- Catalytic Processes in Materials Science
- ATP Synthase and ATPases Research
Tsinghua University
2016-2025
Beijing Tsinghua Chang Gung Hospital
2023-2025
Justus-Liebig-Universität Gießen
2023
Creative Commons
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking Union Medical College Hospital
2023
Hainan Medical University
2021
(1) Background: To develop a novel capillary refill time measurement system and evaluate its reliability reproducibility. (2) Methods: Firstly, the utilization of electromagnetic pressure technology facilitates automatic compression instantaneous release finger. Secondly, employment sensing photoelectric volumetric pulse wave analysis enables dynamic monitoring blood flow in distal tissues. Thirdly, subjects were recruited to compare average number measurements required for successful...
Sepsis is an organ dysfunction syndrome caused by the body's dysregulated response to infection. Yet, due heterogeneity of this disease process, diagnosis and definition sepsis a critical issue in clinical work. Existing methods for early have low specificity.This study evaluated diagnostic predictive values pyroptosis-related genes normal patients their role immune microenvironment using multiple bioinformatics analyses machine-learning methods.Pediatric microarray datasets were screened...
Sepsis-induced acute lung injury (SALI) is a critical illness with high mortality, and pulmonary microvascular endothelial cells (PMECs) barrier dysfunction well-documented pathogenesis of SALI. The current study aimed to investigate the underlying mechanism Reduning (RDN) in treatment SALI.Network pharmacology molecular dynamics simulation (MDS) were used confirm possibility key active components RDN combining AKT1. Hematoxylin-eosin staining (HE) immunohistochemistry (IHC) effect vivo....
Sepsis, a disease caused by severe infection, has high mortality rate. At present, there is lack of reliable algorithmic models for biomarker mining and diagnostic model construction sepsis. Programmed cell death (PCD) been shown to play vital role in occurrence progression, different PCD-related genes have the potential be targeted treatment In this paper, we analyzed Implicated PCD processes include apoptosis, necroptosis, ferroptosis, pyroptosis, netotic death, entotic lysosome-dependent...
(1) Background: Both sepsis acute lung injury (SALI) and non-small-cell cancer (NSCLC) are life-threatening diseases caused by immune response disorders inflammation, but the underlining linking mechanisms still not clear. This study aimed to detect shared gene signature potential molecular process between SALI NSCLC. (2) Methods: RNA sequences patient information on NSCLC were acquired from Gene Expression Omnibus (GEO) database. Weighted co-expression network analysis (WGCNA) was used...
A Lewis acid-catalyzed three-step tandem synthesis of 9-arylfluorene was developed by simply heating a mixture 2-formyl biphenyl, TsNCO and an arene.
The molecular mechanism of Reduning (RDN) in the treatment sepsis was analyzed based on network pharmacology. system pharmacology method administered to search active ingredients and targets RDN, identify sepsis-related genes, determine RDN sepsis. Cytoscape used build a "drug component-target" screen key compounds. A protein-protein interaction (PPI) constructed using STRING, core were revealed through topological analysis. 404 shared introduced into DAVID Bioinformatics Resources 6.8 for...
A novel ruthenium-catalyzed intramolecular cyclization of a nitrile and an azetidine was developed to achieve one-step synthesis the fused tricyclic 1H-2,3-dihydropyrimido[1,2-a]quinoline, which is core skeleton for more than 100 natural pyoverdines also responsible their fluorescence.
Purpose: To evaluate significant risk variables for sepsis incidence and develop a predictive model rapid screening diagnosis of in patients from the emergency department (ED). Methods: Sepsis-related were screened based on PIRO (Predisposition, Insult, Response, Organ dysfunction) system. Training (n = 1,272) external validation 568) datasets collected Peking Union Medical College Hospital (PUMCH) Beijing Tsinghua Changgung (BTCH), respectively. Variables at time admission. Sepsis...
Purpose AKT1 is an important target in sepsis acute lung injury (SALI). The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database ( https://www.chemdiv.com/complete-list/ ) and use screen for activation agents, which may provide clues research development of new drugs treat SALI. Methods Based existing X-ray structure known AKT activators, large-scale virtual HTS performed small molecules by cascade docking method demonstrated both accuracy...
Introduction: The increasing mortality in patients with sepsis-induced pulmonary fibrosis owes to a lack of effective treatment options. This study aims explore the possibility and possible targets Reduning prevention sepsis-related fibrosis. Methods: active components were searched screened from database analysis platform traditional Chinese medicine (TCM) system pharmacology. GeneCards, human genome database, DisGeNET OMIM checked determine associated DAVID Bioinformatics Resources 6.8 was...
Objective : Numerous epidemiological studies have identified a potential link between sepsis and variety of autoimmune disorders. The primary objective this study is to delve deeper into connection, investigating the causal relationship disorders through application Mendelian randomization (MR). Methods To assess genetic impact on risk relating susceptibility toward immune-related outcomes, we used summary data from largest European genome-wide association (GWAS) these conditions using...
Background: Sepsis is one of the main causes death in critically ill patients with high morbidity and mortality. Circular RNAs (CircRNAs) are aberrantly expressed, play significant regulatory roles many diseases. However, expression profiles functions circRNAs sepsis have not yet been fully clarified. Methods: Our present study performed an RNA sequencing (RNA-seq) analysis to assess vitro. We applied quantitative real-time polymerase chain reaction (RT-qPCR) verify RNA-seq results. The...
This abstract has been published in the Abstracts of 2015 Vascular Annual Meeting: The Society for Surgery. DOI: http://dx.doi.org/10.1016/j.jvs.2015.04.299
Abstract The method allows the synthesis of various substituted target compounds.