Abstract 2‐Propargyl alcohols are widely used in organic reactions. Their great success is rooted the presence of multiple functional groups. This review will focus on six types mechanisms: (i) 2‐propargyl as carbocation precursors, (ii) alkynes electrophiles, (iii) nucleophiles, (iv) fracture via ketones or elimination into alkene intermediates, (v) oxidation alkynyl‐ ortho ‐quinone methides carbonyl and (vi) ring expansions. Reactions involving alkanes, alkenes, alkynes, arenes, alcohols,...

Abstract Azides are important intermediates in organic synthesis. They can function as precursors to form amines, amides, quinolones, pyridines, triazoles, amidines, indoles, and so on. Although there some reviews about the applications of azides, few concerned their fundamental mechanisms. This review will focus on recent advances azides based three reactivity patterns, which may enlighten further research. magnified image

Abstract An efficient metal‐free sulfenylation of indoles with disulfides has been developed, leading to 3‐arylthioindoles in moderate excellent yields. Furthermore, bromosulfenylation realized for the first time providing a new family 2‐bromo‐3‐arylthioindole derivatives good yield by one‐pot construction CS and CBr bonds. It is noteworthy that system enables use both RS moieties RSSR shows broad functional group tolerance.

Abstract The development of a methodology for the preparation arylboronic acids or arylboronates is significant interest to organic chemists. Classical synthetic methods prepare these organoboron compounds are based on reaction Grignard lithium reagents with trialkyl borates. In past few decades, transition‐ metal‐catalyzed borylation aryl halides, pseudohalides, and C–H bonds hydrocarbons has been powerful tool synthesis in modern synthesis. These transformations generally considered...

Abstract Ynones are widely used in organic synthesis. Their great success is rooted their multiple functional groups. This review focus on advance of ynones published the decade 2009–2019. Reactions triggered by conjugate addition nitrogen‐, carbon‐, oxygen‐, boron‐, silicon‐, phosphorus‐, and sulfur‐containing nucleophiles thoroughly discussed summarized herein. Multicomponent reactions, rearrangements, cycloadditions, regio‐ stereoselective synthesis, oxidations, coupling, green chemistry...

Abstract Aryl diazonium salts are important molecules in organic chemistry. This review discusses advances of their application light‐mediated reactions summarized five categories according to the bond formations: (1) C−C formation from alkenes, alkynes, arenes, isocyanide, CO, arylboronic acid, or Grignard reagent. (2–5) C−B, C−N, C−S, and C−P formations. Reactions such as radical addition, elimination, metal‐catalyzed coupling, C−H activation, cyclizations, rearrangements will be discussed herein.

Abstract Alkenes are valuable feedstocks in organic synthesis. Selenium or sulfur‐containing coumpounds with a neighboring functional group can be easily prepared by direct difunctionalization of alkenes via three‐component reactions. It will reduce the number steps and waste generation, form complicated molecules from simple starting materials. Herein, recent developments (2013–2022) have been summarized two categories: (1) selenylation seleniranium intermediates Se‐centered radicals; (2)...

Overcoming the poor aqueous solubility of small-molecule drugs is a major challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium channel blocker, poorly water-soluble drug. The study aimed to explore potential applications polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) stabilized amorphous dispersions for augmenting oral delivery drugs. Soluplus-stabilized FLDP (FLDP-SSAs) was prepared using two-phase mixing method. samples were...

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us offer the first example of reaction between ketenimine and amide synthesize amidines efficiently.

Propargylamines are extremely versatile and common building blocks in the field of chemistry. This review highlights recent advances made reactions propargylamines between 2009 2019. The reaction types classified into six categories based on trigger mechanisms: (1) amino moieties as leaving groups, (2) hydrogenation, (3) rearrangement, (4) nucleophilic amines, (5) carbons, (6) electrophilic alkynes. We hope that this will promote future research area. 1 Introduction 2 Amino Moieties Leaving...

A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition all its drawbacks can now be avoided completely.

Abstract The great success of cinnamic acids was rooted in their multiple functional groups. Herein, reactions triggered by the radical addition, electrophilic Michael addition and were thoroughly discussed summarized. Multi‐component reactions, rearrangements, stereoselective synthesis, coupling, additions will be depicted detail. This review focused on advances last decade (2010–2020). We hope this good for a better understanding these reagents future research.

Abstract In existing CuAAC methods, the 1,4,5‐trisubstituted 1,2,3‐triazole unit usually was synthesized by trapping 5‐metal‐1,2,3‐triazole intermediate (M=Cu, Bi or Al) with an electrophile. But, no 5‐dialkylamino‐1,2,3‐triazole has yet been for unknown reasons. We found that this problem may be caused strong oxidizing property of amine electrophile (R 2 N + ) low reactivity MC bond in intermediate. However, when a polymeric complex 1‐copper(I)‐alkyne used as substrate, highly reactive...

By simply heating the mixture of an arylaldehyde and a sulfonylisocyanate in solvent or neat form under catalyst- additive-free conditions, desired N-sulfonylimine was produced with release carbon dioxide. The method is characterized by its unique clean efficiency, convenience, scalability, but it reported to fail half century ago.

Abstract 2‐Alkynylaryl aldehydes are widely used in organic reactions. Their great success is rooted their multiple functional groups. This review will focus on five kinds of triggered mechanisms: (i) as electrophiles, (ii) alkynes (iii) 5‐ exo ‐ dig reactions, (iv) 6‐ endo intermediates, and (v) imine intermediates via cyclizations. Reactions with alkenes, alkynes, arenes, malononitrile, alcohols, amines, amides, acetal, ketones, hydrazine, iodobenzene, azides, carbenes, arylboronic acids,...

Triarylmethanes are important molecules in organic chemistry. This review discusses advances their synthesis summarized five categories according to the starting materials: (1) benzyl reagents with different leaving groups, such as alcohols, ethers, esters, phosphates, sulfones, thioethers, sulfonamide, 1,3-dicarbonyls, and ammonium salts; (2) reactions via para- or ortho-quinone methides; (3) arylation of halides; (4) C–H activation methylenes; (5) aldehydes N-tosylhydrazones....

Abstract A novel method for the synthesis of 3‐iodoquinolines was developed by copper‐catalyzed tandem annulation from diaryliodoniums, nitriles, and 1‐iodoalkynes. It is a that characterized most convenient operation wide molecular diversity. magnified image

Recent advances of β ‐keto acids were summarized as five categories according to their triggered mechanisms: (1) decarboxylative enolate nucleophiles; (2) addition without decarboxylation; (3) electrophilic acids; (4) nucleophilic (5) ketones. We hope this review will promote future research in area.