A5100354352- Supramolecular Chemistry and Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Synthesis and Properties of Aromatic Compounds
- Luminescence and Fluorescent Materials
- Supramolecular Self-Assembly in Materials
- Metal complexes synthesis and properties
- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Reactions
- Analytical Chemistry and Chromatography
- Oxidative Organic Chemistry Reactions
- Synthesis and Reactivity of Heterocycles
- Organic Light-Emitting Diodes Research
- Click Chemistry and Applications
- Covalent Organic Framework Applications
- Surface Chemistry and Catalysis
- Coenzyme Q10 studies and effects
- Chemical Reaction Mechanisms
- Chromatography in Natural Products
- Photoreceptor and optogenetics research
Shanghai Jiao Tong University
2021-2024
Peking University
2022
Lishui University
2020
Huzhou University
2012
Jishou University
2010-2011
Pingdingshan University
2009-2010
Fujian Institute of Microbiology
2003
Bristol-Myers Squibb (United States)
2003
Duquesne University
1998-1999
University of Saskatchewan
1994
We present the rational design of an organic cage combining electron-donating (D) triazatruxene and electron-accepting (A) triphenyl triazine connected by three electronically inert pillars. This controlled architecture leads to a precise spatial separation cofacial alignment D A motifs. Such induces efficient intramolecular through-space charge transfer (TSCT), providing small singlet–triplet energy difference (ΔEST) 0.049 eV, thus gives rise thermally activated delayed fluorescence (TADF)...
The spontaneous resolution of racemates, from natural compounds to artificial structures, has long been pursued shed light on the origin homochirality in life. Even though diverse synthetic systems have elegantly devised elaborate underlying principles symmetry breaking, their complexity is still unparalleled masterpieces including DNA helix and proteins, which convey remarkable coalescence at both molecular supramolecular levels. Here, we report a pair homochiral entities racemic mixture...
Abstract Chirality, with its intrinsic symmetry‐breaking feature, is frequently utilized in the creation of acentric crystalline functional materials that exhibit intriguing optoelectronic properties. On other hand, development chiral crystals from achiral molecules offers a solution bypasses need for enantiopure motifs, presenting promising alternative and thereby expanding possibilities self‐assembly toolkit. Nevertheless, rational design prefer spontaneous symmetry breaking during...
Herein, we report the first example of chiral donor–acceptor cage DA-2 displaying efficient circularly polarized thermally activated delayed fluorescence (CP-TADF) with | g lum values up to 2.1 × 10 −3 and PLQY 32%.
Catenanes have gained increasing attention for their unique features such as topological chirality. To date, the majority of works focused on catenanes comprising monocyclic rings. Due to lack efficient synthetic strategy, multiannulated monomers remain scarce. Here, we report one-pot synthesis an interwoven trimeric cage-catenane in high yield by dynamic imine condensation between diamine linkers suitable length and trialdehyde panels stoichiometry. The formation is driven 6-fold π-π...
Abstract The great success of cinnamic acids was rooted in their multiple functional groups. Herein, reactions triggered by the radical addition, electrophilic Michael addition and were thoroughly discussed summarized. Multi‐component reactions, rearrangements, stereoselective synthesis, coupling, additions will be depicted detail. This review focused on advances last decade (2010–2020). We hope this good for a better understanding these reagents future research.
Elevated levels of tumor necrosis factor-alpha (TNF-alpha) have been associated with several inflammatory diseases, and therefore, strategies for its suppression become important targets in drug discovery. Our efforts to suppress TNF-alpha centered on the inhibition converting enzyme (TACE) through use hydroxamate inhibitors. Starting from broad-spectrum matrix metalloproteinase (MMP) inhibitors, we designed synthesized novel benzothiadiazepines as potent selective TACE The were variation P1...
A variety of organic cages with different geometries have been developed during the last decade, most them exhibiting a single cavity. In contrast, number featuring pair cavities remains scarce. These structures may pave way towards novel porous materials emergent properties and functions.We herein report on rational design three-dimensional hexaformyl precursor 1, which exhibits two types conformers, i.e. Conformer-1 -2, cleft positions sizes. Aided by molecular dynamics simulations, we...
N-hydroxyphthalimide (NHPI) and copper chloride (<TEX>$CuCl_2$</TEX>) were first utilized for aerobic oxidation of <TEX>${\alpha}$</TEX>-isophorone (<TEX>${\alpha}$</TEX>-IP) to ketoisophorone (KIP) the effects co-catalysts, temperature, reaction time, solvent, amount <TEX>$CuCl_2$</TEX> pressure oxygen investigated extensively. NHPI/<TEX>$CuCl_2$</TEX> turned out be highly efficient this with up 91.3% conversion 81.0% selectivity under mild conditions. And various hydrocarbons including...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTReactions of 6-Aminopyrimidines with Biselectrophiles: Manipulation Product Composition Solvent and Pyrimidine Substitution Variation1Anil Vasudevan, Farahnaz Mavandadi, Lihua Chen, Aleem GangjeeView Author Information Division Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282 Cite this: J. Org. Chem. 1999, 64, 2, 634–638Publication Date (Web):December 15, 1998Publication History...
Abstract Chirality, with its intrinsic symmetry‐breaking feature, is frequently utilized in the creation of acentric crystalline functional materials that exhibit intriguing optoelectronic properties. On other hand, development chiral crystals from achiral molecules offers a solution bypasses need for enantiopure motifs, presenting promising alternative and thereby expanding possibilities self‐assembly toolkit. Nevertheless, rational design prefer spontaneous symmetry breaking during...
In the title complex, [Cu(NCS)(2)(C(12)H(19)N(3))], Cu(II) atom is five-coordinated in a square-pyramidal geometry defined by one pyridine N, imine and amine N of tridentate Schiff base ligand two N-bonded thio-cyanate ions (one latter occupying apical site). The three bridging C atoms terminal are disordered over sets sites, with occupancies 0.465 (2) 0.535 (2).
In the title compound, [Cu(C(8)H(7)O(2))(NO(3))(C(10)H(8)N(2))], Cu(II) ion is five-coordinate in a distorted square-pyramidal geometry. The basal positions are occupied by two N atoms from 2,2'-bipyridine ligand and O 2-acetyl-phenolate anion. axial position one atom of nitrate bipyridine ligand, pyridine rings slightly twisted an angle 3.5 (1)°. crystal structure stabilized C-H⋯O hydrogen bonds.
Absorption is crucial to the resultant efficacy of oral drugs where intestinal bacteria flora functions as one first-pass effects.The present study investigated biotransformation psoralenoside and isopsoralenoside in Chinese medicine Psoraleae Fructus(the dried fruit Psoralea corylifolia) with internationally recognized human model vitro.Pso-ralenoside were anaerobically incubated at 37 ℃, respectively, products analyzed identified using high-performance liquid chromatography-tandem mass...
Abstract The synthesis of seven novel tetracyclic 2,4‐diaminopyrrolo[2,3‐ d ]pyrimidines as conformationally restricted nonclassical antifolates was achieved via an unusual Fischer‐indole cyclization dihydrazones. An attempted 2,4‐diamino‐6‐hydrazinopyrimidine afforded 2‐amino‐4,6‐dihydrazinopyrimidine which when reacted with appropriate ketones gave the dihydrazones in turn under conditions target products.
In the title compound, C22H16N2OS2, phenanthrene ring is nearly perpendicular to phenyl ring, making a dihedral angle of 87.2 (2)°. Intramolecular N—H⋯O interactions are present. crystal structure, molecules linked through intermolecular C—H⋯O interactions. The structure also stabilized by C—H⋯π and weak π–π contacts [centroid-centroid distance = 3.36 (6) Å].
Abstract A penta‐coordinated Cu(II) complex with mixed ligands 4, 4′‐bipyridine (4,4′‐bpy) and 2‐pyrazine‐5‐carboxylate anion (2‐pzc), [Cu(4,4′‐bpy)(2‐pzc)(H 2 O)]CIO 4 ·H z O (1), has been solvothermally synthesized characterized. Complex 1 crystallizes in the monoclinic space group P / n a = 0.82996(2) nm, b 1.58156(5) c 1.53837(1) β 103.536(2)°, V 1.96322(8) nm 3 , M r 478.30, Z D 1.618 g/cm final R 0.0544 wR 0.1487. The Structure of indicates that central atom is by two N atoms from...
Catenanes as interlocked molecules with a nonplanar graph have gained increasing attention for their unique features such topological chirality. To date, the majority of research in this field has been focusing on catenanes comprising monocyclic rings. Due to lack rational synthetic strategy, cage-like monomers are hardly accessible. Here we report construction an interwoven trimeric catenane that is composed achiral organic cages, which exhibits Our design begins pure mathematical analysis,...
In the title compound, C(12)H(10)Br(2)O(3), dihedral angle between furan-5(2H)-one ring and benzene is 1.2 (3)°. Two intra-molecular C-H⋯O inter-actions occur in mol-ecule, both of which generate S(6) rings. The bromo-ethyl fragment disordered over two sets sites a 0.773 (8):0.227 (8) ratio. crystal, inversion dimers linked by pairs C-H⋯π occur.