A5061483745- Immune Cell Function and Interaction
- Hepatitis C virus research
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- Systemic Lupus Erythematosus Research
- Diabetic Foot Ulcer Assessment and Management
- Thyroid Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Sleep and Wakefulness Research
- Diabetes and associated disorders
- Traditional Chinese Medicine Studies
- Thyroid Cancer Diagnosis and Treatment
- Fungal Plant Pathogen Control
- Graphene and Nanomaterials Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- biodegradable polymer synthesis and properties
- Advanced Glycation End Products research
- Hand Gesture Recognition Systems
- Virology and Viral Diseases
- Polysaccharides and Plant Cell Walls
- Neuroendocrine Tumor Research Advances
Fuzhou University
2023-2024
Shanghai University of Traditional Chinese Medicine
2023
Hubei University of Chinese Medicine
2023
China Medical University
2021-2022
First Hospital of China Medical University
2022
Southwest University
2022
Guangxi Medical University
2021
Zhengzhou University of Light Industry
2021
University of Illinois Chicago
1997-2016
Versiti Blood Center of Wisconsin
1999-2002
Abstract The root of Angelica sinensis (Oliv.) Diels, a well-known Chinese herbal medicine, has been used historically as hematopoietic and anti-inflammatory agents for thousands years. Recent phytochemistry pharmacological studies have proved that polysaccharides are one the major active ingredients in A. . It demonstrated ASPs ( polysaccharides) had various important biological activities, such hematopoietic, hepatoprotective, hypoglycemic, anti-inflammatory, antitumor, antioxidant...
One of the most disturbing features hepatitis C virus (HCV) is its long-term persistence in host. hypothesis to explain this phenomenon that HCV escapes immune recognition through intrinsic hypermutability. To determine whether immunodominant T cell epitopes derived from nonstructural 3 (NS3) protein might be subject sequence variations leading escape mutants, we examined one IL-2-producing epitope, NS3358-375, and IL-10-producing NS3505-521. By PCR amplification, cloning, sequencing,...
The association of human leukocyte antigen (HLA) genes with the outcome hepatitis C virus (HCV) infection may be modified by ethnic and geographical differences. HLA-A, -C, -DRB1 -DQB1 genotyping were performed in a Midwestern American cohort 105 HCV infected subjects among which 49 cleared 56 had persistent viral infection. A new protective HLA-Cw*05 to all populations was identified (OR = 0.12, 95% CI 0.01–0.97, P 0.03). It surprising that HLA-A*02 (P for interaction 0.02) HLA-DRB1*12...
Numerous investigators have postulated that one mechanism by which hepatitis C virus (HCV) may evade the immune system is through formation of escape mutants. This hypothesis based largely on observed mutability viral genome resulting in evolution diverse quasispecies over course infection. That such diversification a product RNA polymerase infidelity, immune-driven selection or combination two processes has not been addressed. We examined sequence variability specific segment HCV encoding...
An abnormal microenvironment underlies poor healing in chronic diabetic wounds. However, effectively modulating the of wound remains a great challenge due to sustained oxidative stress and inflammation. Here, we present unimolecular enzyme–polymer conjugate that demonstrates excellent multienzymatic cascade activities. The cascaded enzyme conjugates (CECs) were synthesized by grafting poly(N-acryloyl-lysine) (pLAAm) from glycan moieties glucose oxidase (GOx) via glycan-initiated...
Gray mold (Botrytis elliptica) causes a deleterious fungal disease that decreases the ornamental value and yield of lilies. Lilium oriental hybrid ‘Sorbonne’ is variety resistant to gray mold. Understanding mechanism resistance against B. elliptica infection in can provide basis for genetic improvement lily plants. In this study, PacBio Sequel II system was used sequence full-length transcriptome after inoculation with elliptica. A total 46.64 Gb subreads 19,102 isoforms an average length...
During optimal motility conditions, a 1:1 stoichiometry of CheA(L) (654 amino acids) to CheA(S) (557 was determined. It also found that CheZ binding inhibited by CheA(L)-CheA(S)-CheW interaction. This suggests has different functions in the phosphorylating complex (CheA(L)-CheA(S)-CheW) and dephosphorylating (CheA(S)-CheZ).
Background Hypothyroidism in the first trimester of pregnancy (T1) has great adverse effects on mothers and foetuses. However, few studies have investigated influence postpartum thyroid dysfunction. This study aimed to evaluate their long-term effect function within one year after delivery. Methods In total, 151 women were recruited from 1496 participants classified as newly diagnosed subclinical hypothyroidism (SCH) T1 (ND-SCH, n=50), previously known SCH before (PK-SCH, n=51) overt (PK-OH,...
We have examined and compared at the molecular level three strains of wild-type yellow fever (YF) virus isolated from Senegal in 1927, 1953 1965, termed French viscerotropic virus, Rendu Dak1279 respectively. Over structural protein genes, differed other two by 8% nucleotide level. also antigenically, possessing a 'vaccine'-specific envelope (E) epitope (i.e. an previously shown to be found on 17D neurotropic vaccine viruses only not YF virus). Consequently, we propose that least distinct...
Antigenic variation is an effective way by which viruses evade host immune defense leading to viral persistence. Little known about the inhibitory mechanisms of variants on CD4 T cell functions. Using sythetic peptides a HLA-DRB1*15-restricted epitope derived from non-structural (NS) 3 protein hepatitis C virus (HCV) and its antigenic peripheral blood mononuclear cells (PBMC) six HLA-DRB1*15-positive patients chronically infected with HCV healthy subjects, in vitro responses phenotypes...
BackgroundAPOBEC family play an important role in cancer mutagenesis and tumor development. The of APOBEC lung adenocarcinoma (LUAD) has not been studied comprehensively.Materials methodsThe expression data pan-cancer as well LUAD was obtained from public databases. level genes analyzed different normal tissues. enrichment score (AMES) utilized to evaluate the APOBEC-induced mutations relation with genomic instability. Gene set analysis used identify differentially enriched pathways....
Ovarian serous cystadenocarcinoma (OSCC) is a life-threatening malignancy with poor prognosis. Therefore, the identification of immune-related genes associated OSCC prognosis may reveal new targets immunotherapy for OSCC.The gene expression profiles overlapped were extracted by weighted co-expression network analysis (WGCNA) to identify modules. Significant identified univariate Cox regression model genes. Model characteristic obtained least absolute shrinkage and selection operator (LASSO)...
Enzymes are crucial for various technological applications, but their inherent instability and short lifespan pose challenges. This study presents facile immobilized enzyme technology with the development of thermoresponsive enzyme-polymer conjugates (EPCs), using glucose oxidase (GOx) as a model enzyme, to address these limitations. By conjugating heteropolymers glycan moieties GOx through precise