A5101948565- Tendon Structure and Treatment
- Cellular Mechanics and Interactions
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Microfluidic and Bio-sensing Technologies
- Polymer Surface Interaction Studies
- Electron and X-Ray Spectroscopy Techniques
- Gastrointestinal Tumor Research and Treatment
- Force Microscopy Techniques and Applications
- Acoustic Wave Resonator Technologies
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- Musculoskeletal pain and rehabilitation
- Ultrasound Imaging and Elastography
- Veterinary Equine Medical Research
- Advanced Electron Microscopy Techniques and Applications
- Infrared Thermography in Medicine
- Proteoglycans and glycosaminoglycans research
- Characterization and Applications of Magnetic Nanoparticles
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- interferon and immune responses
- Advanced Fiber Optic Sensors
- Tuberous Sclerosis Complex Research
- Periodontal Regeneration and Treatments
Hangzhou Dianzi University
2024
UPMC Hillman Cancer Center
2020-2023
Institute of Psychology, Chinese Academy of Sciences
2023
University of Chinese Academy of Sciences
2023
University of Pittsburgh
2011-2022
Pittsburg State University
2015
Bethune International Peace Hospital
2014
Air Force Medical University
2013
Moffitt Cancer Center
2013
Fudan University Shanghai Cancer Center
2011
Background Cellular adaptation to a hypoxic microenvironment is essential for tumor progression and largely mediated by HIF-1α through coordinated regulation of hypoxia-responsive genes. The chemokine SDF-1α its unique receptor CXCR4 have been implicated in organ-specific metastases many cancers. In this study, we investigated the response osteosarcoma cells hypoxia expression human specimens explored roles cell migration process. Methodology/Principal Findings We performed...
Treatment of tendon–bone junction injuries is a challenge because interface often heals poorly and the fibrocartilage zone, which reduces stress concentration, at not formed. In this study, we used compound called kartogenin (KGN) with platelet-rich plasma (PRP) to induce formation zone in rat tendon graft–bone tunnel model. The experimental rats received KGN-PRP or PRP injections interface. control group saline. After 4, 8 12 weeks, Safranin O staining tunnels revealed abundant...
Epithelial IFN-β couples radiation-induced intestinal stem cell injury with local inflammation and regeneration.
Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither X-ray crystal nor cryo-EM structure CB2-orthosteric ligand-modulator has been resolved, prohibiting drug discovery development CB2 allosteric modulators (AMs). In present work, we mainly focused on investigating potential binding site(s) CB2. We applied different algorithms or tools to predict sites with existing agonists. Seven can be observed for either CB2-CP55940 CB2-WIN 55,212-2...
Previous animal studies have shown that long term rat treadmill running induces over-use tendinopathy, which manifests as proteoglycan accumulation and chondrocytes-like cells within the affected tendons. Creating this model of tendinopathy by is however time-consuming, costly may vary among animals. In study, we used a new approach to develop an using kartogenin (KGN), bio-compound can stimulate endogenous stem/progenitor differentiate into chondrocytes. KGN-beads were fabricated implanted...
Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis tendinopathy unclear. Here we report that high mobility group box1 (HMGB1) released to tendon extracellular matrix and initiates an inflammatory cascade in response mechanical mouse model. Moreover, administration glycyrrhizin (GL), naturally occurring triterpene specific inhibitor HMGB1, inhibits tendon's reactions. Also, while prolonged form long-term intensive treadmill running induces Achilles mice,...
Rotator cuff injury healing is problematic because the tendon-bone junction often forms cicatricial tissues, rather than fibrocartilage, which leads to mechanical impairment and prone redamage. Kartogenin (KGN) a newly discovered small molecule compound can induce cartilage formation through chondrogenesis of endogenous mesenchymal stem cells. In this study, we used KGN with fibrin glue (FG) repair rotator by promoting fibrocartilage at tendon bone interface. Firstly, assessed release rate...
Cell traction force (CTF) plays a critical role in controlling cell shape, permitting motility, and maintaining cellular homeostasis many biological processes such as angiogenesis, development, wound healing, cancer metastasis. Calponin is an actin filament-associated cytoskeletal protein smooth muscles multiple types of non-muscle cells. An established biochemical function calponin the inhibition myosin ATPase muscle Vertebrates have three isoforms. Among them, 2 expressed epithelial cells,...
Increasing evidence indicates that secretion of high mobility group box 1 protein (HMGB-1) is functionally associated with tendinopathy development. However, the underlying effect and mechanism extracellular HMGB-1 on tendon cells are unclear.We tested exogenous cell growth, migration, inflammatory signaling responses isolated rat Achilles cells. Also, we studied role HMGB-1, when administrated alone or in combination mechanical overloading induced by intensive treadmill running (ITR),...
Background: MicroRNAs are short regulatory RNAs that negatively modulate protein expression at a post-transcriptional and/or translational level and deeply involved in the pathogenesis of several types cancers.Specifically, microRNA-221 (miR-221) is overexpressed many human cancers, wherein accumulating evidence indicates it functions as an oncogene.However, function miR-221 osteosarcoma has not been totally elucidated.In present study, effects on possible mechanism by which affected...
It is known that anterior cruciate ligament (ACL) of the knee joint prone to injuries with poor healing potential. The capacity a tissue-like ACL dependent on its structural components and properties stem cells (SCs). Therefore, this study aimed characterize structure tissue SCs derived from components.The rabbit was determined using scanning electron microscope, hematoxylin eosin, immunohistochemical staining. biological were studied by colony formation, cell proliferation assay, SC marker...
Cell adhesion to a substrate or extracellular matrix (ECM) plays an important role in variety of cellular functions, such as cell migration, proliferation, differentiation, and tissue formation. Shear-horizontal surface acoustic wave (SH-SAW) sensors can detect behaviors liquid non-invasive, simple quantitative manner. As the key part SH-SAW, acoustic-wave guiding layer crucial improving sensor performance. Parylene-C (poly(2-chloro-p-xylylene)) has been proven ideal due its good uniformity,...
This paper proposes the first pure Transformer structure inversion network called SwinStyleformer, which can compensate for shortcomings of CNNs framework by handling long-range dependencies and learning global objects. Experiments found that with backbone could not successfully invert image. The above phenomena arise from differences between Transformers, such as self-attention weights favoring image ignoring details compared to convolution, lack multi-scale properties Transformer,...
Abstract Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis tendinopathy unclear. Here we report that high mobility group box1 (HMGB1) released to tendon extracellular matrix and initiates an inflammatory cascade in response mechanical mouse model. Moreover, administration glycyrrhizin (GL), naturally occurring triterpene specific inhibitor HMGB1, tendon’s reactions. Also, while prolonged form long-term intensive treadmill running induces Achilles mice,...
Myc is a key driver of colorectal cancer initiation and progression, but remains difficult drug target. In this study, we show that mTOR inhibition potently suppresses intestinal polyp formation, regresses established polyps, prolongs lifespan APCMin/+ mice. Everolimus in diet strongly reduces p-4EBP1, p-S6, levels, induces apoptosis cells with activated β-catenin (p-S552) the polyps on day 3. The cell death accompanied by ER stress, activation extrinsic apoptotic pathway, innate immune...
4E-BP1 is a tumor suppressor regulating cap-dependent translation that in turn controlled by mechanistic target of rapamycin (mTOR) or cyclin-dependent kinase 1 (CDK1) phosphorylation. serine 82 (S82) phosphorylated CDK1, but not mTOR, and the consequences this mitosis-specific phosphorylation are unknown. Knock-in mice were generated with single S82 alanine (S82A) substitution leaving other sites intact. S82A fertile exhibited no gross developmental behavioral abnormalities, homozygotes...
10562 Background: To investigate the status of KIT and PDGFRA mutations in gastrointestinal stromal tumors (GIST) its clinical implication China. Methods: 141 GISTs were evaluated for presence mutations. Exon 9, 11, 13, 17 exon 12, 18 analyzed by PCR amplification direct sequencing. The features, prognostic factors, mutational their relationships with statistical tools this study. Results: Generally, identified 76.6% (108/141) all our GISTs: 70.2% (99/141) involving 5.7% (8/141) 0.7% (1...
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