A5031696488- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Nuclear physics research studies
- Atomic and Molecular Physics
- Phase Change Materials Research
- Integrated Energy Systems Optimization
- Smart Grid Energy Management
- Invertebrate Immune Response Mechanisms
- Adsorption and Cooling Systems
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Astronomical and nuclear sciences
- Tribology and Wear Analysis
- Mechanical Failure Analysis and Simulation
- Phytochemical compounds biological activities
- Electric Power System Optimization
- Chemical Synthesis and Analysis
- Mechanical stress and fatigue analysis
- Microgrid Control and Optimization
- Neutrino Physics Research
- Advanced Chemical Physics Studies
- Antimicrobial agents and applications
- Quantum Chromodynamics and Particle Interactions
- Insect Utilization and Effects
- Polydiacetylene-based materials and applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Yunnan University
2024-2025
Peking Union Medical College Hospital
2025
Northeast Electric Power University
2024
China University of Petroleum, Beijing
2024
Peking University
2017-2023
State Key Laboratory of Nuclear Physics and Technology
2017-2023
Antimicrobial peptides (AMPs) represent a promising strategy for combating antibiotic-resistant bacterial infections; however, their therapeutic application remains limited by high toxicity and poor stability. In this study, we designed class of core-shell nanoparticles through the self-assembly an imperfectly amphipathic peptide, with fatty acids varying chain lengths acting as stabilizing agents. The lead nanoparticle, designated GV2, demonstrated superior antibacterial efficacy, safety,...
The emergence of multidrug-resistant (MDR) bacteria presents a significant challenge to public health, increasing the risk infections that are resistant current antibiotic treatment. Antimicrobial peptides (AMPs) offer promising alternative conventional antibiotics in prevention MDR bacterial infections. In present study, we identified novel cathelicidin AMP from Gekko japonicus, which exhibited broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria, with...
Cathelicidins, a major class of antimicrobial peptides (AMPs), hold considerable potential for drug development. In the present study, we identified novel cathelicidin AMP (TC-33) derived from Chinese tree shrew. Despite TC-33 demonstrating weak activity, peptide TC-14, developed based on its active region, exhibited 432-fold increase in activity over parent peptide. Structural analysis revealed that TC-14 adopted an amphipathic α-helical conformation. The bactericidal mechanism involved...
Background: Beta-decay spectroscopy provides valuable nuclear physics input for thermonuclear reaction rates of astrophysical interest and stringent test shell-model theories far from the stability line. Purpose: The available decay properties proton drip-line nucleus $^{27}$S is insufficient to constrain key resonance in $^{26}$Si$(p,\gamma)^{27}$P rate probe possible isospin asymmetry. scheme complicated being understood, which has motivated but also presented challenges our experiment....
The advancement of antimicrobial peptides (AMPs) as therapeutic agents is hindered by their poor selectivity. Recent evidence indicates that controlled disruption the amphipathicity α-helical AMPs may increase This study investigated role imperfect in optimizing with varied sequences to enhance activity and Among these, lead peptide RI-18, characterized an imperfectly amphipathic structure, demonstrated potent broad-spectrum antibacterial without inducing hemolytic or cytotoxic effects....
The decay properties of the short-lived isotope $^{220}\mathrm{Pa}$ were re-investigated via reaction $^{40}\mathrm{Ar}+^{187}\mathrm{Re}$ at gas-filled recoil separator Spectrometer for Heavy Atoms and Nuclear Structure. digital pulse processing technique was applied to resolve evaporation residues--$\ensuremath{\alpha}$ ($\mathrm{ER}\ensuremath{-}\ensuremath{\alpha}$) pileup signals in $^{220}\mathrm{Pa}$. $\ensuremath{\alpha}$-decay chain leading well-known $^{216}\mathrm{Ac}$ established...
The number of cationic residues and net charge are critical for the activity antimicrobial peptides (AMPs) due to their role in facilitating initial electrostatic interactions with negatively charged bacterial membranes. A cathelicidin AMP (TC-33) has been identified from Chinese tree shrew our previous work, which exhibited weak activity, likely its moderately nature. In current study, based on TC-33, we designed a novel by peptide truncation Glu substitutions increase +4 +8. resulting...
The $\ensuremath{\alpha}$ decay of $^{222}\mathrm{U}$ was reinvestigated using a general least-square superpulse fitting algorithm dedicated to resolving pileup signals in the very short-lived nuclei. $\ensuremath{\alpha}$-particle energy revised be 9246(8) keV, and precision improved significantly compared with previous result. Using present energy, anomaly systematics $\ensuremath{\alpha}$-decay reduced width ${\ensuremath{\delta}}^{2}$ observed at ${N}_{p}{N}_{n}$ scheme is solved, all...
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