A5100346452- Nuclear Physics and Applications
- Nuclear reactor physics and engineering
- Kruppel-like factors research
- Nuclear physics research studies
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Astrophysics and Star Formation Studies
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Circular RNAs in diseases
- Genetic and phenotypic traits in livestock
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Chalcogenide Semiconductor Thin Films
- RNA Research and Splicing
- Radiation Detection and Scintillator Technologies
- Quantum Dots Synthesis And Properties
- Genetic Syndromes and Imprinting
- Wnt/β-catenin signaling in development and cancer
- Cytokine Signaling Pathways and Interactions
- Genomics and Chromatin Dynamics
- Hippo pathway signaling and YAP/TAZ
Chongqing University of Technology
2023-2025
Qujing Normal University
2025
Chinese Academy of Sciences
2015-2024
Kunming Institute of Zoology
2013-2024
National Astronomical Observatories
2021-2024
University of Chinese Academy of Sciences
2024
University of Science and Technology of China
2018-2023
China Academy of Engineering Physics
2007-2023
Shenzhen Institutes of Advanced Technology
2017-2023
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2023
Phylogeny and characteristics of ruminants Ruminants are a diverse group mammals that includes families containing well-known taxa such as deer, cows, goats. However, their evolutionary relationships have been contentious, the origins distinctive digestive systems headgear, including antlers horns (see Perspective by Ker Yang). To understand among ruminants, L. Chen et al. sequenced 44 species representing 6 performed phylogenetic analysis. From this analysis, they were able to resolve...
Abstract P2‐type Na 0.67 Ni 0.33 Mn O 2 is considered as a potential cathode material for sodium‐ion batteries due to the merits of high voltage, low cost, and air stability. However, unsatisfied cycling stability rate performance caused by destructive phase transition side reactions hinder its practical application. Herein, we present feasible dual strategy Mg 2+ doping integrated with ZrO surface modification P2‐Na , which can well address issues benefitting from enhanced structural...
Abstract The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes cell proliferation, survival, migration tumour growth. Here we show that, cells, stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, identify BAP1 as bona fide DUB. interacts directly with stabilizes via deubiquitination. BAP1/HCF-1 complex, this newly identified complex cycle progression partially inhibiting p27 gene expression. Furthermore, knockdown...
It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth A (VEGFA) axis to promote angiogenesis in breast cancer. However, it unclear how this negatively regulated. In study, we demonstrated miR-153 directly inhibits expression of HIF1α by binding 3'UTR HIF1A mRNA, as suppresses tube formation primary human umbilical vein cells (HUVECs) and cancer decreasing secretion VEGFA. Importantly, was induced hypoxia-stimulated ER stress,...
Triple-negative breast cancer (TNBC) is currently the most malignant subtype of cancers without effective targeted therapies.Mifepristone (MIF), a drug regularly used for abortion, has been reported to have anti-tumor activity in multiple hormone-dependent cancers, including luminal type cancers.In this study, we showed that MIF suppressed tumor growth TNBC cell lines and patient-derived xenografts NOD-SCID mice.Furthermore, reduced stem (CSC) population through down-regulating KLF5...
Abstract Triple‐negative breast cancer (TNBC) has higher molecular heterogeneity and metastatic potential the poorest prognosis. Because of limited therapeutics against TNBC, irradiation (IR) therapy is still a common treatment option for patients with lymph nodes or brain metastasis. Thus, it urgent to develop strategies enhance sensitivity TNBC tumors low‐dose IR. Here, authors report that E3 ubiquitin ligase Ring finger protein 126 (RNF126) important IR‐induced ATR‐CHK1 pathway activation...
Krüpple-like transcription factor 5 (KLF5) is a zinc-finger promoting cell survival and tumorigenesis in multiple cancers. A high expression level of KLF5 has been shown to be associated with shorter breast cancer patient survival. However, the role mechanism actions remain unclear. In this study, we found that knockdown by small interfering RNA two lines, MCF10A BT20, induces apoptosis. Interestingly, pro-survival phosphatase, dual specificity mitogen-activated protein kinase phosphatase 1...
Abstract To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an ligase siRNA library containing pools against 555 individual E3s using the sulphorhodamine B assay in MDA-MB-231 breast cancer cell line and PC3 prostate line. RNF126 was identified validated a candidate from this screening. Knockdown of dramatically decreased viability these lines. Consistently, knockdown delayed cell-cycle G1–S progression proliferation. Using protein array analysis found that...
Purpose: To test the amblyopic suppression at mid to low spatial frequencies when compensating for signal attenuation. Methods: Eight amblyopes with (n = 5) or without 3) strabismus and 10 normal controls corrected visual acuity (≥20/20) stereopsis (≤40 arcseconds) participated. Using a quick contrast sensitivity function approach, we measured individuals' monocular functions untested eye saw mean luminance background bandpass filtered noise whose peak frequency was matched that of grating....
We have identified 453 compact dense cores in 3 mm continuum emission maps the ATOMS (ALMA Three-millimeter Observations of Massive Star-forming regions) survey, and compiled three catalogues high-mass star forming cores. One catalogue, referred to as H/UC-HII includes 89 that enshroud hyper/ultra (H/UC) HII regions characterized by associated H40alpha emission. A second pure s-cHMC, 32 candidate Hot Molecular Cores (HMCs) showing rich spectra (N>20lines) complex organic molecules (COMs) but...
Abstract The PMEPA1 gene has been shown to suppress the androgen receptor (AR) and TGFβ signaling pathways is abnormally expressed in prostate tumours. However, role mechanism action of AR‐negative cancer are unclear. Here, we demonstrate that inhibition suppresses RWPE1 PC‐3 cell proliferation through up‐regulating p 21 transcription. Additionally, overexpression p21 expression promotes proliferation. induced by as a negative feedback loop Smad3 phosphorylation nuclear translocation;...
Progesterone (Pg) promotes normal breast development during pregnancy and lactation increases the risk of developing basal-type invasive cancer. However, mechanism action Pg has not been fully understood. In this study, we demonstrate that mRNA protein expression Klf5, a pro-proliferation transcription factor in cancer, was dramatically up-regulated mouse pregnant lactating mammary glands. Pg, but estrogen prolactin, induced Krüpple-like 5 (KLF5) multiple receptor (PR)-positive cancer cell...
The transcription factor KLF5 (Krüpple-like 5) is highly expressed in basal-like breast cancer (BLBC), which promotes cell proliferation, survival, migration and stemness, serving as a potential therapeutic target.In the current study, super-enhancer (SE) was identified to be located downstream of gene BLBC lines, HCC1806 HCC1937.JQ-1, BRD4 inhibitor, inhibits expression activity both HCC1937 cells time-and dose-dependent manner.Compound 870, an in-house exhibited higher potency than JQ-1...
Abstract Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs a key step during extravasation hematogenous metastasis. Surgery common intervention for most primary solid tumors. However, surgical trauma-related systemic inflammation facilitates metastasis by increasing spread to vascular (ECs). Currently, there are no effective interventions prevent Here, we show that HECTD3 deficiency...
Abstract Hemagglutinin (HA) is an important glycoprotein on the surface of influenza virus, which involved in virus attachment to host cells through viral membrane and fusion with cell form cells. H3N2 inhibitors can bind hydrophobic cavities at HA pre‐polymer interface, preventing its conformational rearrangement ultimately inhibiting fusion. In this study, 46 imidazole [1, 2‐α] pyrimidine derivatives were analyzed using two different analytical methods (CoMFA CoMSIA) a reliable 3D‐QSAR...
A high regio‐ and chemoselectivity route to the synthesis of 4‐quinolone derivatives involving a CsF‐catalyzed [2 + 4] tandem annulations under continuous‐flow reactor has been developed. This practical concise protocol between aryne precursors β‐enamino diesters provided range structurally diverse 4‐quinolones (28 examples) in good excellent yields. The characteristics this are safe operation, short time. approach can enrich develop chemistry, might provide new opportunities for discovery drugs.
The Krüppel-like factor 5 (KLF5) has been suggested to promote breast cell proliferation, survival and tumorigenesis. KLF5 protein degradation is increased by several E3 ubiquitin ligases, including WWP1 SCFFbw7, through the ubiquitin-proteasome pathway. However, deubiquitinase (DUB) of not demonstrated. In this study, we identified ATXN3L as a DUB genome-wide siRNA screening. directly binds KLF5, decreasing its ubiquitination thus degradation. Functionally, knockdown inhibits cancer...