A5100781632- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Legume Nitrogen Fixing Symbiosis
- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Biological Research and Disease Studies
- Advanced Nanomaterials in Catalysis
- ATP Synthase and ATPases Research
- Metabolomics and Mass Spectrometry Studies
- Lepidoptera: Biology and Taxonomy
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Polysaccharides and Plant Cell Walls
- Hematopoietic Stem Cell Transplantation
Macau University of Science and Technology
2021-2025
Quality Research
2025
Cincinnati Children's Hospital Medical Center
2020-2022
Shanxi Medical University
2020
Peking University
2020
Beijing Jiaotong University
2020
China Pharmaceutical University
2016-2019
Inner Mongolia Medical University
2018
Shandong Entry-Exit Inspection and Quarantine Bureau
2014
Institute of Agrobiological Sciences
2007
Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), which enter the host cells through interaction between its receptor binding domain (RBD) of spike glycoprotein with angiotensin-converting enzyme (ACE2) on plasma membrane cell. Neutralizing antibodies and peptide binders RBD can block viral infection, however, concern accessibility affordability infection inhibitors has been raised. Here, we report identification natural compounds as potential...
The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, and RA pathogenesis remain unexplored. Here we show that accumulation fragments, age regulated by exonuclease TREX1, promotes abnormal activation immune system an adjuvant-induced (AIA) rat model. Local overexpression TREX1 suppresses synovial inflammation rats, while conditional genomic deletion AIA rats result...
Polycomb repressive EED protein orchestrates WNT, BMP, and senescence pathways to ensure proper CNS myelination repair.
Abstract Chromatin organization is critical for cell growth, differentiation, and disease development, however, its functions in peripheral myelination myelin repair remain elusive. In this report, we demonstrate that the CCCTC-binding factor (CTCF), a crucial chromatin organizer, essential Schwann regeneration after nerve injury. Inhibition of CTCF or deletion blocks differentiation at pro-myelinating stage, whereas overexpression promotes program. We find establishes interaction loops...
Triple-negative breast cancer (TNBC) relies primarily on aerobic glycolysis for energy and rapid cell proliferation. Hexokinase 2 (HK2), a key enzyme regulating glycolysis, is overexpressed in TNBC, promoting tumor proliferation apoptosis resistance by interacting with the mitochondrial membrane's voltage-dependent anion channel 1 (VDAC1). However, development of bioactive molecules effectively disrupting HK2-VDAC1 interaction remains challenging. Herein, we have modified londamine (LND) an...
The oligodendrocyte (OL) lineage transcription factor Olig2 is expressed throughout oligodendroglial development and essential for progenitor specification differentiation. It was previously reported that deletion of enhanced the maturation myelination immature OLs accelerated remyelination process. However, by analyzing multiple conditional KO mouse lines (male female), we conclude has opposite effect required OL remyelination. We found in driven an OL-expressing Plp1 promoter resulted...
Vibrio parahaemolyticus is a common foodborne bacterial pathogen, which survives in cold environments and sometimes difficult to culture. Fatty acid analysis under stress was conducted for several V. strains using gas chromatography/mass spectrometry, the results were compared with those of controls. All fatty profiles obtained visualized by multidimensional scaling (MDS) self-organized map (SOM). It observed that substantially changed stress. The percentage methyl palmitate remarkably...
Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 mutants are commonly described as the guardian cancer cells conferring them drug-resistance and evasion. Importantly, mutations have also been identified in RA patients, this prompts investigation its role pathogenesis.The cytotoxicity disease-modifying anti-rheumatic drugs (DMARDs) against wild-type (WT)/mutant-transfected fibroblast-like synoviocytes (RAFLSs) was evaluated...
Background: Isocitrate dehydrogenase 2 (IDH2) is an enzyme catalyzing the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) in tricarboxylic acid (TCA). Evidences suggest that specific mutations IDH2 are critical growth and reproduction severe tumors especially leukemia glioblastoma. It found inhibitors mutant promising anti-tumor therapeutics. Methods: A virtual screening strategy combining molecular similarity search docking was performed binding site AGI-6780. YL-16, YL-17...
Gold Nanoparticle Aggregates In article number 2101190, Jinjian Liu, Yumin Zhang, Jianfeng Liu and co-workers report a multifunctional hybrid hydrogel for triple-synergistic destruction of tumor DNA functions. The sustained release DOX can prevent replication; meanwhile, gold nanoparticle aggregates exacerbate damage inhibit self-repair via dual-sensitization, i.e., radiosensitization photo-sensitization. This strategy achieves highly efficient antitumor efficacy.
Abstract Capable of inducing antigen-specific immune responses in both systemic and mucosal compartments without the use syringe needle, vaccination is considered ideal for global control infectious diseases. In this study, we developed a rice-based oral vaccine expressing cholera toxin B subunit (CTB). An average 30 μg CTB per seed was stored protein body, rice storage organelle. When orally fed, seeds were taken up by M cells covering Peyer′s patches (PPs), toxin-specific serum IgG IgA...
Objective To design and synthesize a novel permeable hydrogel loaded with radiation agent for the implantation radiotherapy of tumors. Methods The polymer PECT-RGD[PECT: poly(e-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(e-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone); RGD: Arg-Gly-Asp] was synthesized by esterification reaction, an 131I-labeled hyaluronic acid prepared amidation reaction chloramine-T method. The chemical structure them...
Objective According to the clinical and gene mutation characteristics of ACADVL-related very long chain acyl-CoA dehydrogenase deficiency(VLCADD), types that contribute ACADVL were summarized. Methods By analyzing clinical, laboratory genetic data 1 case with deficiency diagnosed from Department Pediatrics, Affiliated Hospital Inner Mongolia Medical University in August 2016, based on agreement signed by both little patient′s parents hospital, plus high-throughput sequencing analysis...
Abstract BackgroundAt present, a lack of knowledge the molecular mechanisms underlying genesis and progression colorectal cancer (CRC) exists. This is one reasons for poor prognosis this increasingly occurring disease. The purpose our research to identify candidates therapeutic intervention that would help stop malignant CRC.MethodsIn study, we performed bioinformatic analysis combined microarray data GSE40967 GSE8671 in Gene Expression Omnibus (GEO) CRC RNA-seq dataset Cancer Genome Atlas...