A5101794431- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Surface Modification and Superhydrophobicity
- Carbon and Quantum Dots Applications
- Adsorption and biosorption for pollutant removal
- Membrane Separation Technologies
- Advanced Sensor and Energy Harvesting Materials
- Nanomaterials for catalytic reactions
- Nanoplatforms for cancer theranostics
- Advanced Photocatalysis Techniques
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Covalent Organic Framework Applications
- Sulfur Compounds in Biology
- Lipid metabolism and biosynthesis
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Fluorescence Microscopy Techniques
- Extraction and Separation Processes
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Analytical chemistry methods development
- Photochromic and Fluorescence Chemistry
Anhui University
2016-2025
University of Science and Technology of China
2013-2025
Hong Kong Baptist University
2024-2025
Henan Institute of Science and Technology
2025
Jiangsu University
2017-2024
Beijing Aerospace Flight Control Center
2023-2024
Macau University of Science and Technology
2022-2024
Tianjin University of Science and Technology
2023
Guilin University of Electronic Technology
2023
Liaoning Technical University
2022-2023
Fluorescent probes are powerful tools for the investigations of reactive oxygen species (ROS) in living organisms by visualization and imaging. However, multiparallel assays several ROS with multiple often limited available number spectrally nonoverlapping chromophores together large invasive effects discrepant biological locations. Meanwhile, spontaneous profilings various organs/tissues also penetration capability across different barriers stability vivo environments. Here, we report a...
Abstract The dynamics of DNA and RNA structures in live cells are important for understanding cell behaviors, such as transcription activity, protein expression, apoptosis, hereditary disease, but challenging to monitor organisms real time. difficulty is largely due the lack photostable imaging probes that can distinguish between RNA, more importantly, capable crossing multiple membrane barriers ranging from cell/organelle tissue/organ level. We report discovery a cationic carbon quantum dot...
Superior photostability, minimal phototoxicity, red-shifted absorption/emission wavelengths, high brightness, and an enlarged Stokes shift are essential characteristics of top-tier organic fluorophores, particularly for long-lasting super-resolution imaging in live cells (e.g., via stimulated emission depletion (STED) nanoscopy). However, few existing fluorophores possess all these properties. In this study, we demonstrate a general approach simultaneously enhancing parameters through the...
Classical pH test papers are widely used to measure the acid–base degree of media in a qualitative or semiquantitative manner. However, extension portable and inexpensive methods wide range analytes so as eliminate tediousness instrumental assays remains unsuccessful. Here, we report novel kind dual-colored carbon dot (CD) ratiometric fluorescent paper for assay copper ions (Cu2+) by dose-sensitive color evolution. The preparation is based on following two interesting findings: one hand,...
Intracellular lipid metabolism occurs in droplets (LDs), which is critical to the survival of cells. Imaging LDs an intuitive way understand their physiology live However, this limited by availability specific probes that can properly visualize vivo. Here, LDs-specific red-emitting probe proposed address need, not merely with ultrahigh signal-to-noise (S/N) ratio and a large Stokes shift (up 214 nm) but also superior resistance photobleaching. The has been successfully applied real-time...
Inspired by the mastoid structure of lotus leaf and robust layered nacre, a novel nacrelike graphene oxide–calcium carbonate (GO–CaCO3) hybrid mesh with superhydrophilic underwater superoleophobic property was prepared for first time, via facile, economical, environmentally friendly layer-by-layer (LBL) self-assembly method using commercially available stainless steel (SSM) as ready-made mask. Interestingly, GO nanosheets played threefold role, regulating growth CaCO3 nanocrystals between...
Visualizing and dynamic tracking lipid droplets (LDs) are of great importance to biological research. Herein, two-photon absorption fluorescent small bioprobes based on lipophilic coumarin were developed, which exhibited high selectivity toward LDs in HeLa cells. Because good biocompatibility excellent photostability, the probes applied realize specific super-resolution visualization intracellular cells, offering us quantitative results amount diameters as well. Furthermore, capable...
Graphene oxide has widely been employed in various fields, but its structure and composition still not fully understood. Here we report that freshly prepared graphene exhibits a large number of π-conjugated carbon radicals at π-network plane, which result from the addition reaction hydroxyl H2O2 onto conjugated double bonds oxide. The can directly initiate long-lasting visible chemiluminescence luminol, is even stronger than obtained when horseradish peroxidase are used. Previously, was...
Introducing reversible ionic interaction is one of the most effective methods to achieve self-healing behavior in rubbers. However, strength rubbers only containing an cross-linking network quite limited, and their long-term stability questionable. In this work, polar epoxidized natural (ENR) filled with zinc dimethacrylate (ZDMA) were vulcanized a peroxide cure system obtain material. We controlled vulcanization parameters inhibit formation covalent constructed composed cross-linking....
Real-time monitoring of dynamic microvesicles (MVs), vesicles associated with living cells, is great significance in deeply understanding their origin, transport, and function. However, specific labeling MVs poses a challenge due to the lack unique biomarkers that differentiate them from other cellular compartments. Here, we present strategy selectively label by evaluating series lipid layer-sensitive cationic indolium-coumarin fluorescent probes (designated as IC-Cn, n ranging 1 18) feature...
Distinguishing tumor cells from normal holds the key to precision diagnosis and effective intervention of cancers. The fundamental difficulties, however, are heterogeneity lack truly specific ideally universal cancer biomarkers. Here, we report a concept cell detection, bypassing genotypic phenotypic features different types directly going toward hallmark cancer, uncontrollable growth. Combining spherical nucleic acids (SNAs) with exquisitely engineered molecular beacons (SNA beacons, dubbed...
Abstract Understanding the biomolecular interactions in a specific organelle has been long‐standing challenge because it requires super‐resolution imaging to resolve spatial locations and dynamic of multiple biomacromolecules. Two key difficulties are scarcity suitable probes for nanoscopy complications that arise from use probes. Herein, we report quinolinium derivative probe is selectively enriched mitochondria switches on three different fluorescence modes response hydrogen peroxide (H 2...
The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, and RA pathogenesis remain unexplored. Here we show that accumulation fragments, age regulated by exonuclease TREX1, promotes abnormal activation immune system an adjuvant-induced (AIA) rat model. Local overexpression TREX1 suppresses synovial inflammation rats, while conditional genomic deletion AIA rats result...
Abstract Vinyldiazo compounds are one of the most important synthons in construction a cyclic ring. Most photochemical transformations vinyldiazo mainly focusing on utilization their C═C bond site, while reactions taking place at terminal nitrogen atom largely unexplored. Herein, photocatalytic cascade radical cyclization LBRs with reagents through sequential B─N/C─N formation is described. The reaction starts addition (Lewis base–boryl radicals) diazo followed by intramolecular to access...