A5076799260- Cervical Cancer and HPV Research
- Dementia and Cognitive Impairment Research
- Cassava research and cyanide
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Genital Health and Disease
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Sleep and related disorders
- Magnetic Properties and Synthesis of Ferrites
- Nanoparticle-Based Drug Delivery
- Plant Molecular Biology Research
- Sleep and Wakefulness Research
- Plant Micronutrient Interactions and Effects
- Iron oxide chemistry and applications
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- Sirtuins and Resveratrol in Medicine
- Maternal Mental Health During Pregnancy and Postpartum
- Endometrial and Cervical Cancer Treatments
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Advanced Sensor and Energy Harvesting Materials
- Head and Neck Anomalies
- Hepatitis B Virus Studies
Hebei Medical University
2014-2025
First Affiliated Hospital of Hebei Medical University
2014-2025
Jinan University
2025
Beijing Tian Tan Hospital
2025
Children's Hospital of Zhejiang University
2023-2025
Capital Medical University
2025
National Clinical Research Center for Digestive Diseases
2023-2025
National Cancer Institute
2018-2024
National Institutes of Health
2019-2024
Center for Cancer Research
2018-2024
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset papillomavirus-related cancers. often occurs by linearizing viral E1/E2 region, resulting loss critical early polyadenylation signal (PAS), which is essential for E6E7 bicistronic transcripts and expression E6 E7 oncogenes. Here, we provide compelling evidence that, despite presence numerous integrated copies, virus-host fusion originate from only single HPV16 HPV18 cervical cancers cancer-derived cell lines....
Article18 July 2019Open Access Transparent process Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling Tao Wang Guangdong Province Key Laboratory of Animal Nutritional Regulation, College Science, South China Agricultural University, Guangzhou, Guangdong, Search for more papers by this author Ya-Qiong Xu Ye-Xian Yuan Ping-Wen Division Endocrinology, Department Medicine, The University Illinois at Chicago, IL, USA Cha Zhang Fan Li Li-Na Cong Yin Lin Xing-Cai Cai Can-Jun...
Abstract Excessive inflammation poses a major challenge to wound care, with massive exudation and bacterial infection being the prominent factors contributing inflammation. Current biomaterials can achieve passive or interactive repair through exudate absorption anti‐infection. However, they cannot actively modulate cellular behavior associated skin repair. Inspired by endogenous electric field (EF), present study develops an antimicrobial self‐powered electrical fabric dressing (EFD). An...
Abstract Ischemic stroke is the most common cerebrovascular disease and leading cause of permanent disability worldwide. Recent studies have shown that development prognosis are closely related to abnormal tryptophan metabolism. Here, significant downregulation 3‐hydroxy‐kynurenamine (3‐HKA) in patients animal models identified. Supplementation with 3‐HKA improved long‐term neurological recovery, reduced infarct volume, increased ipsilateral cerebral blood flow after distal middle artery...
Alternative RNA splicing is an important focus in molecular and clinical oncology. We report here that SRSF3 regulates alternative of interleukin enhancer binding factor 3 (ILF3) production this double-strand RNA-binding protein. An increased coexpression ILF3 isoforms was found various types cancers. isoform-1 isoform-2 promote cell proliferation transformation. Tumor cells with reduced expression produce aberrant isoform-5 -7 ILF3. By to sequence motifs, the by exclusion/inclusion exon 18...
// Lu-Lu Yu 1 , Wen Chen Xiao-Qin Lei Qin Ze-Ni Wu Qin-Jing Pan 2 Xun Zhang Bai-Feng Chang Shao-Kai 3 Hui-Qin Guo and You-Lin Qiao Department of Cancer Epidemiology, Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing, P. R. China Pathology, Henan Affiliated Hospital Zhengzhou University, Office for Control Research, Zhengzhou, Correspondence to: Guo, email: Qiao, Keywords : cervical cancer; p16/Ki-67 dual staining; human papillomavirus; women; Pathology Section Received...
Human papillomavirus type 16 (HPV16) E7 oncoprotein plays an essential role in cervical carcinogenesis and is encoded predominantly by E6*I mRNA through alternative RNA splicing of a P97 promoter-transcribed bicistronic E6E7 pre-mRNA. Recently, HPV16 circular RNA, circE7, was detected two HPV16-positive cancer cell lines, CaSki SiHa. It generated back-splicing the The reported findings showed that, because viral nuclear, mainly translated from cytoplasmic knockdown circE7 cells led to...
<b><i>Background:</i></b> Mild cognitive impairment (MCI) has been suggested as a term for boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in elderly Hebei province, China, explore its related factors. <b><i>Methods:</i></b> Participants included 2,601 community-dwelling people aged 60 years or older who resided four major cities province. In stage 1 study, Mini-Mental State...
The relationship between HPV viral load and histological grades in the development of cervical cancer is argument. It helpful to better understand association by quantitatively detecting HPV16, 18, a pool 12 other high‐risk type (OT) independently on samples precancer cancer. A cross‐sectional study was performed five medical centers China. Histological diagnosis made local pathologists adjudicated via pathology expert panel. fully automated real‐time PCR test used for measurement OT, human...
Cellular non-membranous RNA-granules, P-bodies (RNA processing bodies, PB) and stress granules (SG), are important components of the innate immune response to virus invasion. Mechanisms governing how a modulates PB formation remain elusive. Here, we report roles GW182 DDX6, but not Dicer, Ago2 DCP1A, in formation, that Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection reduces through several specific interactions with viral RNA-binding protein ORF57. The wild-type ORF57, its...
Objective: To evaluate device survival and identify risk factors for failure in pediatric cochlear implant (CI) surgery to guide strategies minimizing rates improving outcomes. Methods: A retrospective analysis was conducted on patients who underwent CI at the Children’s Hospital, Zhejiang University School of Medicine, from September 2008 2023. Device assessed using Kaplan-Meier method while independent influencing were analyzed log-rank test Cox regression model. Results: Among 602...
Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer’s disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process human brain. Regional homogeneity (ReHo) rapidly maps regional across whole In present study, we used ReHo index explore pattern MCI. Our results showed that MCI subjects displayed increased paracentral lobe, precuneus, and...
<title>Abstract</title> In addition to its well-established role in vision, environmental light also plays a crucial non-image-forming visual functions, including the regulation of instinctive behaviors such as feeding. Clinical evidence suggests that bright therapy can alleviate symptoms individuals with obesity. However, neural mechanisms underlying influence on feeding remain poorly understood. this study, we demonstrate treatment effectively reduces food intake and mitigates weight gain...
Background: Ischemic stroke is the most common cerebrovascular disease worldwide and leading cause of permanent disability, which imposes a heavy burden on society families. Currently, there are still limited treatments for improving long-term recovery after cerebral infarction. Recent studies have found that development prognosis closely related to abnormal tryptophan metabolism. In this study, we aimed identify metabolites with ischemic protective effects in patients animal models...
SRSF3 (SRp20) is an essential splicing factor. We discovered Srsf3 plays oncogenic role in breast cancer and knockout (KO) mammary glands delays the development of Erbb2 mouse model. In contrast, tumor-suppressive liver tissues. KO hepatocytes enhances DEN-induced disrupts sex disparity cancer. Comparing to WT cancer, significantly increases Sox4, E2f1, Trpv4, Trim6, Myc expression, but does not so inhibits expression Mfsd4a Eif4a2 Moreover, suppresses ERα Foxa genes reduce Lifr Egfr induce...