A5101971583- Biomedical Text Mining and Ontologies
- Cancer-related molecular mechanisms research
- Semantic Web and Ontologies
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Topic Modeling
- Quinazolinone synthesis and applications
- Circular RNAs in diseases
- Computational Drug Discovery Methods
- Natural Language Processing Techniques
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Pharmacological Effects of Natural Compounds
- Biosensors and Analytical Detection
- Machine Learning in Bioinformatics
- Identification and Quantification in Food
- RNA Research and Splicing
- Antibiotic Resistance in Bacteria
- ATP Synthase and ATPases Research
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
Wuhan Institute of Virology
2011-2025
Chinese Academy of Sciences
2011-2025
National Institutes of Health
2013-2024
National Cancer Institute
2016-2024
China-Japan Friendship Hospital
2019-2024
Center for Cancer Research
2017-2024
Wenzhou Medical University
2011-2023
North China University of Science and Technology
2021-2022
Northeast Agricultural University
2020-2022
Linyi People's Hospital
2021
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset papillomavirus-related cancers. often occurs by linearizing viral E1/E2 region, resulting loss critical early polyadenylation signal (PAS), which is essential for E6E7 bicistronic transcripts and expression E6 E7 oncogenes. Here, we provide compelling evidence that, despite presence numerous integrated copies, virus-host fusion originate from only single HPV16 HPV18 cervical cancers cancer-derived cell lines....
Identifying unknown drug interactions is of great benefit in the early detection adverse reactions. Despite existence several resources for drug-drug interaction (DDI) information, wealth such information buried a body unstructured medical text which growing exponentially. This calls developing mining techniques identifying DDIs. The state-of-the-art DDI extraction methods use Support Vector Machines (SVMs) with non-linear composite kernels to explore diverse contexts literature. While...
The wide variety of morphological variants domain-specific technical terms contributes to the complexity performing natural language processing scientific literature related molecular biology. For analysis these texts, lemmatization has been actively applied in recent biomedical research. In this work, we developed a tool, BioLemmatizer, for literature. tool focuses on inflectional morphology English and is based general MorphAdorner. BioLemmatizer further tailored biological domain through...
Exploring the virus infection mechanisms is significant for defending against and providing a basis studying endocytosis mechanisms. Single-particle tracking technique powerful tool to monitor in real time obtaining dynamic information. In this study, we reported quantum-dot-based single-particle efficiently globally research behaviors individual cells. It was observed that many influenza viruses were moving rapidly, converging microtubule organizing center (MTOC), interacting with acidic...
Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on diseases complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no tissue-derived CMC models that have ever been developed, as well visualized affinity comparison potential active between normal and columns. In this study, a novel comparative normal/failing rat myocardium analysis system based online column selection...
Abstract Eukaryotic five-methylcytosine (m 5 C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m C sites are identified hepatitis B virus (HBV) mRNA. The modification at nt 1291 not only indispensable for Aly/REF export factor (ALYREF) recognition to promote mRNA HBx translation but also the inhibition RIG-I binding suppress interferon-β (IFN-β) production. Moreover, NOP2/Sun...
Background Emodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies. This study was designed investigate whether emodin could the angiogenesis tissues its mechanism. Methodology/Principal Finding In accordance with study, inhibited cell growth, induced apoptosis, enhanced anti-tumor effect gemcitabine on caner vitro vivo by inhibiting activity NF-κB. Here, for first time, we demonstrated that implanted tissues, decreased...
Significance Persistent infections of oncogenic HPVs can lead to cervical, anogenital, and head-and-neck cancers. We report that HPV-infected cervical lesions display aberrant expression 194 long-noncoding RNAs, including lnc-FANCI-2 . show that, in cell tissue cultures, is induced primarily by the HPV E7 protein via interacting with a cellular transcription factor YY1. infection also increases YY1 reducing miR-29a, which targets 3′ UTR RNA. In vivo vitro, nearby DNA repair gene FANCI...
Evodiamine has therapeutic potential against cancers.This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer.In vitro application of the triggered significantly higher frequency cancer cells apoptosis, inhibited activities PI3K, Akt, PKA, mTOR PTEN, decreased activation NF-κB expression NF-κB-regulated products.In vivo induced significant enhancement tumor cell reductions volume, PTEN.In conclusion,...
The biomedical text mining community has focused on developing techniques to automatically extract important relations between biological components and semantic events involving genes or proteins from literature. In this paper, we propose a novel approach for in the literature using approximate subgraph matching. Extraction of such knowledge is performed by searching an isomorphism key contextual dependencies input sentence graphs. Our significantly increases chance retrieving encoded...
Among cyclin-dependent kinase inhibitors that control the G1 phase in cell cycle, only p18 and p27 can negatively regulate haematopoietic stem (HSC) self-renewal. In this manuscript, we demonstrate protein is a more potent inhibitor of HSC self-renewal than mouse models its deficiency promoted expansion long-term culture. Single-cell analysis indicated deleting gene favoured self-renewing division vitro. Based on structure in-silico screening, further identified novel small-molecule...
Gemcitabine resistance is a common problem of pancreatic cancer chemotherapy, and how to reverse it plays an important role in the treatment cancer. This study investigated effect emodin on gemcitabine-resistant cell line SW1990/Gem, explored potential mechanism its action. SW1990/Gem was obtained by culture SW1990 vitro intermittently increasing concentration gemcitabine medium for 10 months, observing morphology using inverted microscopy. cells were pretreated with (10 µM) different...
We propose a method for automatic extraction of protein-specific residue mentions from the biomedical literature. The searches text amino acids at specific sequence positions and attempts to correctly associate each mention with protein also named in text. methods presented this work will enable improved functional site articles, ultimately supporting function prediction. Our made use linguistic patterns identifying acid Further, we applied an automated graph-based learn syntactic...
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for replication of various viruses. Despite function m5C deposition is well characterized, other potential roles in regulating remain largely unknown. In this study, modified residues catalyzed by enterovirus 71 (EV71) RNAs were mapped. NSUN2, along with modifications, played multiple during EV71 life cycle. Functional nucleotides increased...
Abstract Background It has been demonstrated that swine waste is an important reservoir for resistant genes. Moreover, the bacteria carrying genes and originating from feces wastewater could spread to external environment. Fluoroquinolones (FQs) are widely used in livestock poultry treatment of bacterial infection. However, resistance FQs increased markedly. Results In this study, were sampled 21 farms seven provinces China investigate prevalence FQ resistance, including plasmid-mediated...
Colistin is the last line of defense for treatment multidrug-resistant gram-negative bacterial infections. However, colistin resistance gradually increasing worldwide, with commonly regulated by two-component system and mcr gene. Thus, this study aimed to investigate molecular epidemiology colistin-resistant mechanism mcr-positive mcr-negative Escherichia coli isolates from animal in Sichuan Province, China. In study, a total 101 E. strains were isolated 300 fecal samples six farms Province....
Abstract RNA modifications play crucial roles in metabolism, structure, and functions. N4-acetylcytidine (ac4C) have been shown to enhance stability translation efficiency of messenger RNAs viral RNAs. However, the relationship between ac4C alternative processing remains unexplored. Here, N-acetyltransferase 10 (NAT10) its catalyzed on minute virus canines (MVC) were regulate DNA replication processing, including both splicing polyadenylation. Through acRIP-seq RedaC:T-seq, functional...
ABSTRACT Histone modifications function in both cellular and viral gene expression. However, the roles of acetyltransferases histone acetylation parvoviral infection remain poorly understood. In current study, we found deacetylase (HDAC) inhibitor, trichostatin A (TSA), promoted replication transcription parvovirus minute virus canines (MVC). Notably, expression host KAT5, GTF3C4, KAT2A was increased MVC infection, as well H4 (H4K12ac). KAT5 is not only responsible for H4K12ac but also...
Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic (ATCs). Although ATCs are in an very aggressive status cause more death than PTCs, their difference poorly understood at molecular level. In this study, we focus on the transcriptome among normal tissue published dataset including 45 tissues, 49 PTCs 11 ATCs, by applying machine learning method, maximum relevance minimum redundancy, identified 9 genes...
Background/Aims: Nasopharyngeal cancer (NPC) is one of the common human malignant diseases all over world, and chemotherapy remains main therapy for NPC. However, survival life quality NPC patients are still very poor. Thus, novel selective anti-tumor agents pressingly needed. Our previous study identified pectolinarigenin as a effective drug candidate In this study, we further investigated its activities explored potential molecular mechanism. Methods: C666-1 cells were cultured treated by...
SUMMARY Pepino ( Solanum muricatum , 2 n = x 24), a member of the Solanaceae family, is an important globally grown fruit. Herein, we report high‐quality, chromosome‐level pepino genomes. The 91.67% genome sequence anchored to 12 chromosomes, with total length 1.20 Gb and scaffold N50 87.03 Mb. More than half comprises repetitive sequences. In addition shared ancient whole‐genome triplication (WGT) event in eudicots, additional new WGT was present pepino. Our findings suggest that pepinos...
Drug abuse (DA) and addiction is a complex illness, broadly viewed as neurobiological impairment with genetic environmental factors that influence its development manifestation. Abused substances can disrupt the activity of neurons by interacting many proteins, particularly G-protein coupled receptors (GPCRs). A few medicines target central nervous system (CNS) also modulate DA related such GPCRs, which act in conjunction controlled psychoactive substance(s) increase side effects. To fully...