Studies on phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities

• DOI: 10.19540/j.cnki.cjcmm.20200821.201
• Publication Date: 2021-03-01
• Authors: Rongrui Wei; Qinge Ma; Zhipei Sang; Jianghong Dong
• Keywords: Chromatography; Plant Extracts; Hepatocytes; Eleocharis

To study phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities. The compounds were separated purified ethyl acetate part by conventional column chromatography preparative liquid chromatography, structures identified various spectral techniques. HL-7702 cells damage model of hepatocytes induced APAP was used to screen evaluate the activities these compounds. Sixteen isolated E. dulcis, as 6'-(4″-hydroxy-3″-methoxy-phenylpropenyl)-1-(10-methoxy-phenylacetone)-1'-O-β-D-glucopy-ranoside(1), susaroyside A(2), clausenaglycoside B(3), C(4), D(5), emarginone A(6), B(7), thoreliin B(8), 4-O-(1',3'-dihydroxypropan-2'-yl)-dihydroconiferyl alcohol 9-O-β-D-glucopyranoside(9), 2-[4-(3-methoxy-1-propenyl)-2-methoxy-phenoxy]-propane-1,3-diol(10), 6'-O-(E-cinnamoyl)-coniferin(11), methyl 3-(2-O-β-D-glucopyranosyl-3,4,5,6-tetramethoxyphenyl) propanoate(12), A(13), 9-O-(E-cinnamoyl)-coniferin(14), 6'-O-(E-cinnamoyl)-syringin(15), 2'-O-(E-cinnamoyl)-syringin(16). Among them, compound 1 a new compound. Compounds 2-16 this plant for first time. 2 8 showed certain