A5048012510- Garlic and Onion Studies
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Cerebrovascular and Carotid Artery Diseases
- Polysaccharides and Plant Cell Walls
- Antioxidant Activity and Oxidative Stress
- Natural Fiber Reinforced Composites
- Acute Ischemic Stroke Management
- Nutrition and Health in Aging
- Advanced Cellulose Research Studies
- Traditional Chinese Medicine Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Diabetic Foot Ulcer Assessment and Management
- Consumer Attitudes and Food Labeling
- Seaweed-derived Bioactive Compounds
- Pineapple and bromelain studies
Guangzhou University of Chinese Medicine
2024
Shandong Agricultural University
2023-2024
Central South University
2022-2024
Sichuan Agricultural University
2018-2021
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2021
Sichuan Provincial Department of Education
2021
University of Electronic Science and Technology of China
2021
Zhejiang Normal University
2020
Ministry of Agriculture and Rural Affairs
2020
Jinan University
2016-2017
Icariin (ICA) is a pharmacologically active flavonoid glycoside that shows promise in the treatment and prevention of osteoporosis (OP). However, mechanisms underlying anti-osteoporotic effects ICA remain largely unclear. The present study used quantitative polymerase chain reaction, western blot immunohistochemical analysis to examine on several key targets Notch signaling pathway bone tissue ovariectomized rats. It was observed has pronounced beneficial effect OP rats inhibits expression...
Icariin (ICA), the main active flavonoid glucoside isolated from Herba Epimedii, has been shown to prevent postmenopausal bone loss in vitro. However, mechanisms by which ICA prevents vivo remain poorly understood. In present study, effect of an ovariectomized (OVX) rat model osteoporosis was evaluated. Sprague-Dawley rats were divided into sham‑operated and OVX groups. The randomly five groups: group (water only), Fosamax (positive) (5.04 mg/kg, weekly, administered orally), OVX‑ICA groups...
The objective of this study was to elucidate the protective role quercetin in atherosclerosis by examining its effect on phenotypic switch vascular smooth muscle cells (VSMCs) macrophage-like and underlying regulatory pathways. Aorta tissues from apolipoprotein E-deficient (ApoE KO) mice fed a high-fat diet (HFD), treated with or without 100 mg/kg/day quercetin, were analyzed for histopathological changes molecular mechanisms. Quercetin found decrease size atherosclerotic lesions mitigate...
A variety of microRNAs (miRNAs) have been reported to be significantly involved in the regulation vascular smooth muscle cell (VSMC) proliferation, which is an essential process for formation atherosclerotic plaque. The objective present study was explore role microRNA-155 (miR-155) VSMC growth and migration. total 12 plaque samples 9 control were collected, expression levels miR-155/endothelial nitric oxide synthase (eNOS) determined those by RT-qPCR western blot analysis. results revealed...
Klotho is an aging-related marker closely associated with a number of diseases. A growing body evidence suggests that dietary factors and lifestyle habits can impact serum levels. The effect fiber, key component healthy diet, on the body's levels has not been fully elucidated.The aim this study was to explore relationship between fiber intake in people aged 40-79 years United States.A total 11,282 participants were included study, all from National Health Nutrition Examination Survey 2007...
Background: There is increasing evidence suggesting that serum neurofilament light chain (sNfL) levels can be used as biomarkers for axonal injury. Retinol recognized its significant involvement in nervous system function, but the precise connection between dietary retinol and sNfL remains uncertain. Objective: Our objective was to investigate relationship intake sNfL, find an optimal level neurological health. Methods: In National Health Nutrition Examination Survey (NHANES), conducted from...
The study was conducted to investigate the effects of dietary leucine on antioxidant activity and expression antioxidant- mitochondrial-related genes in longissimus dorsi muscle liver piglets. Three diets were formulated with different levels supplemented (0%, 0.25%, 0.5%). Results showed that supplementation 0.25% significantly increased antisuperoxide anion (ASA) antihydroxyl radical (AHR) activities total superoxide dismutade (T-SOD), glutathione peroxidase (GPx), S-transferase (GST),...
Background: The relationship between dietary carbohydrate intake and serum Klotho levels, an aging biomarker, remains uncertain. Objective: This study aimed to investigate the association levels among American adults aged 40–79. Methods: We analyzed data from 10,669 40–79 years who participated in National Health Nutrition Examination Survey (NHANES) 2007 2016. Trained interviewers assessed using a 24 h recall. Serum concentrations were measured commercially available ELISA kits provided by...
Abstract A previous study demonstrated that leucine upregulates the slow myosin heavy chain mRNA expression in C2C12 cells. However, role of slow‐twitch muscle fibers and mitochondrial function porcine skeletal satellite cells as well its mechanism remain unclear. In this study, cultured differentiation medium were treated with 2 mM for 3 days. Sirt1 inhibitor EX 527, AMPK compound C, α1 si RNA used to examine underlying mechanism. Here we showed increased function‐related gene expression,...
This study attempted to screen and combine effective biomarkers analyse the association between these gastrointestinal failure (GIF) in critically ill patients.A total of 110 patients with acute injury (AGI) admitted ICU were enrolled. The AGI grade was determined by classification proposed ESICM. There 67 dysfunction (GID) group (AGI II), 43 GIF III-IV), 41 healthy adults control (HC) group. APACHE II SOFA score used evaluate disease severity. Peripheral blood samples collected within 24...
Bamboo is prone to mould infection and discolouration. Traditional methods of preventing are peel off the green yellow layers, then anti-mould treatment was performed. Though these were efficient, original colour bamboo removed resulted in resources waste because removal portions. This paper presented an property method Moso surface by using a preservation process. The results revealed that outer skin processed certain effect. Based on this result, involving alkali solution copper salt...
The role of dietary iron supplementation in the development nonalcoholic fatty liver disease (NAFLD) remains controversial. This study aimed to investigate effect excess on NAFLD and underlying mechanism. Apolipoprotein E knockout mice were fed a chow diet, high-fat diet (HFD), or an HFD containing 2% carbonyl (HFD + Fe) for 16 weeks. serum samples acquired biochemical histopathological examinations. Isobaric tags relative absolute quantitation performed identify differentially expressed...
Background: This study explored the levels and prognostic value of ischemia modified albumin (IMA), red blood cell distribution width (RDW), lipoprotein (LP) in patients with diabetes melltus (DM) complicated withcoronary heart disease (CHD).Methods: A total 95 DM who were diagnosed treatedfrom January 2018 to 2019 retrospectively analyzed. All included underwent percutaneous coronary intervention (PCI). Patients CHDwere designated group (n=61) without CHD complications B (n=34). During same...
Background: Klotho is widely recognized as a protein that combats aging and possesses antioxidative characteristics, which have been implicated in the pathophysiology of numerous diseases. There emerging evidence suggesting consumption dietary nutrients, particularly those rich antioxidants, could be associated with serum concentrations. Dietary vitamin C one critical nutrients antioxidant properties. Nonetheless, association between concentrations remains unclear. Objective: Aiming to...
Leucine can promote slow-twitch muscle fibers formation, and this effect may be mediated by AMPK signaling pathway. In addition, adiponectin (AdipoQ) plays an important role in regulation of fiber type transformation. AdipoQ is located the upstream its secretion regulated leucine. Therefore, aim study was to explore whether leucine affects transformation through Our data showed that 4 mM significantly increased protein expression levels slow MyHC, Myoglobin, Troponin I-SS, AdipoQ, AdipoR1,...
The "iron hypothesis" of atherosclerosis has long been controversial. Several studies have shown that dietary iron restriction or low-iron diets can effectively alleviate in rabbits and mice. However, the underlying molecular mechanisms these phenomena remain to be elucidated. In this study, we further evaluated possible correlations between a diet alleviation by using quantitative proteomic approach. For purpose, apolipoprotein E knockout (ApoE KO) mice were divided into three groups fed...