A5022801684- Congenital heart defects research
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cardiomyopathy and Myosin Studies
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Tracheal and airway disorders
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Vascular anomalies and interventions
- Physiological and biochemical adaptations
- Adipose Tissue and Metabolism
- Liver Disease and Transplantation
- T-cell and B-cell Immunology
- Cardiovascular Effects of Exercise
- Chemotherapy-induced cardiotoxicity and mitigation
- Nanocluster Synthesis and Applications
Fudan University
2007-2025
Zhongshan Hospital
2007-2025
The First Affiliated Hospital, Sun Yat-sen University
2008-2025
Sun Yat-sen University
2008-2025
Shanxi Provincial Children's Hospital
2015-2025
Chengdu University of Technology
2025
Jiangnan University
2023-2024
Institute of Special Animal and Plant Sciences
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Hebei Normal University of Science and Technology
2023-2024
Background: Mechanical thrombectomy is effective and safe for treating pulmonary embolism (PE). Although the Tendvia mechanical system has been validated in pigs, further evidence supporting its use PE treatment needed. Objectives: This study was aimed at evaluating safety efficacy of intermediate-risk acute PE. Methods: prospective, single-arm, multicenter included symptomatic patients with ≥18 years age, a right ventricular (RV)/left (LV) diameter ratio ≥0.9. The primary endpoint change...
Acute xerostomia is the most common side effect of radiation therapy (RT) for head and neck (H&N) malignancies. Investigating radiation-induced changes computed tomography (CT) radiomics in parotid glands (PGs) saliva amount (SA) can predict acute during RT nasopharyngeal cancer (NPC).CT SA data from 35 patients with stages I-IVB were randomly collected an NPC clinical trial registered on clinicaltrials.gov (ID: NCT01762514). All received radical treatment based intensity-modulated (IMRT) a...
Congenital heart disease (CHD), the most common form of developmental abnormality in humans, remains a leading cause morbidity and mortality neonates.Genetic defects have been recognized as predominant causes CHD.Nevertheless, CHD is substantial genetic heterogeneity underlying cases remain unclear.In current study, coding regions splicing junction sites TBX20 gene, which encodes T-box transcription factor key to cardiovascular morphogenesis, were sequenced 175 unrelated patients with CHD,...
The cardiac T-box transcription factor TBX5 is crucial for proper cardiovascular development, and mutations in have been associated with various congenital heart diseases arrhythmias humans. However, whether mutated contributes to dilated cardiomyopathy (DCM) remains unclear. In this study, the coding exons flanking introns of gene were sequenced 190 unrelated patients idiopathic DCM. available family members index patient carrying an identified mutation 200 ethnically matched healthy...
Congenital heart disease (CHD) is the most common developmental abnormality, and leading noninfectious cause of mortality in neonates. Increasing evidence demonstrates that genetic defects play an important role pathogenesis CHD. However, CHD exhibits substantial heterogeneity, determinants for remain unknown overwhelming majority cases. In current study, coding exons flanking introns HAND2 gene, which encodes a basic helix-loop-helix transcription factor essential normal cardiovascular...
Molecular-based classifications of gastric cancer (GC) were recently proposed, but few them robustly predict clinical outcomes. While mutation and expression signature protein-coding genes used in previous molecular subtyping methods, the noncoding genome GC remains largely unexplored. Here, we developed fast long-noncoding RNA analysis (FLORA) method to study sequencing data cases, prioritized tumor-specific RNAs (lncRNAs) by integrating multi-omic data. We uncovered 1235 lncRNAs, based on...
BACKGROUND:This study aimed to identify hub genes and pathways in a rat model of renal ischemia-reperfusion injury (IRI) using bioinformatics analysis the Gene Expression Omnibus (GEO) microarray dataset integration gene expression profiles. MATERIAL AND METHODS:GEO software GEO2R calculation method were used analyze two mRNA profiles, including GSE 39548 108195. The co-expression differentially expressed (DEGs) identified searched DAVID STRING databases for pathway protein-protein...
Magnetotelluric (MT) forward modeling is a key technique in magnetotelluric sounding, and deep learning has been widely applied to MT modeling. In three-dimensional (3D) problems, although existing methods can predict results with high accuracy, they often use multiple networks simulate parameters, resulting low efficiency. We apply multi-task (MTL) 3D achieve simultaneous inference of apparent resistivity impedance phase, effectively improving overall efficiency.Furthermore, through...
Magnetotelluric (MT) forward modeling is a key technique in magnetotelluric sounding, and deep learning has been widely applied to MT modeling. In three-dimensional (3-D) problems, although existing methods can predict results with high accuracy, they often use multiple networks simulate parameters, resulting low efficiency. We apply multi-task (MTL) 3-D achieve simultaneous inference of apparent resistivity impedance phase, effectively improving overall Furthermore, through comparative...
Acute myeloid leukemia (AML) presents varying prognoses in pediatric and adult patients, with dysregulated m6A-related genes playing a pivotal role its pathogenesis. Through an analysis of single-cell RNA sequencing data from the Gene Expression Omnibus, we uncovered distinct patterns m6A gene expression specific to AML cases. Additionally, devised Lasso risk regression model evaluate prognosis within different subsets, showcasing clinical utility predicting outcomes. Our study underscores...
Abstract Purpose To assess whether measuring the pattern of pancreatic enhancement on gadolinium chelate dynamic magnetic resonance imaging (MRI) is helpful for diagnosis suspected early or mild chronic pancreatitis. Materials and Methods In this retrospective study, 24 patients with pancreatitis, classified by criteria equivocal pancreatitis (ultrasound, computed tomography [CT] ERCP) grading, had MRI that included unenhanced, arterial dominant, venous, late venous phases contrast...
Abstract Background: The zinc finger transcription factor CASZ1 plays a key role in cardiac development and postnatal adaptation, mice, deletion of the Methods: coding exons splicing junction sites Results: A novel heterozygous mutation, p.K351X, was identified an index patient with DCM. Genetic analysis mutation carrier’s family showed that co-segregated DCM, which transmitted autosomal dominant pattern complete penetrance. nonsense absent 400 referential chromosomes, altered amino acid...
Congenital atrial septal defect (ASD) and progressive atriventricular block (AVB) are the two most common phenotypes linked to NK2 homeobox 5 (NKX2.5) mutations in animals humans. However, prevalence spectrum of NKX2.5 mutation patients with ASD AVB remain be elucidated. In present study, coding exons flanking introns gene, which encodes a homeobox‑containing transcription factor essential for development heart, were sequenced cohort 62 unrelated AVB, subsequently carrier's available family...
Irisin is a newly discovered factor that secreted by skeletal muscle and plays an important role in the homeostasis metabolism of energy balance. This study used irisin radiolabeled with <sup>125</sup>I small-animal SPECT/CT imaging to investigate metabolic elimination distribution vivo. was labeled using Iodogen method. Small-animal performed on C57/B16 mice at 15, 30, 60, 120, 240 min after receiving tail vein injection, radioactive organs determined 120 min. revealed highest level...
Abstract Immune checkpoint blockade (ICB) treatment of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection may activate viral-specific T cells to attack HBV infected hepatocytes and thus induce immune-related liver injury. Therefore, it is important deeply understand the impacts on HCC immune microenvironment in order better design effective immunotherapies for + (HBV infected) patients. Here, We performed cytometry by time-of-flight (CyTOF) analyses characterize...
Atopic dermatitis (AD) is a common allergic skin disease, and its pathogenesis involves genetic environmental factors, as well the immune response barrier. PJ‑001 small‑molecule proteolysis‑targeting chimera, which can degrade proteins related to Janus kinase 2/signal transducer activator of transcription 3 (JAK2/STAT3) pathway. In present study, 0.5% 2,4‑dinitrofluorobenzene was used induce mouse model AD. Following treatment with PJ‑001, number scratches severity damage in AD mice were...