A5100362085- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Apelin-related biomedical research
- Bone and Dental Protein Studies
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Lipid metabolism and disorders
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Cholesterol and Lipid Metabolism
- Medical Imaging and Analysis
- Protein Interaction Studies and Fluorescence Analysis
- Genomics, phytochemicals, and oxidative stress
- Spectroscopy Techniques in Biomedical and Chemical Research
- Web and Library Services
- Fatty Acid Research and Health
- Immune Cell Function and Interaction
- Ginger and Zingiberaceae research
- Spine and Intervertebral Disc Pathology
- Lung Cancer Diagnosis and Treatment
- Regulation of Appetite and Obesity
Wuhan Puai Hospital
2024
Huazhong University of Science and Technology
2024
Chongqing Medical University
2006-2023
Southwest Jiaotong University
2023
Chengdu Third People's Hospital
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Deyang Stomatological Hospital
2022
Chengdu Fifth People's Hospital
2021
Qilu Hospital of Shandong University
2016-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2020
The chronic low-grade inflammation of adipose tissues, primarily mediated by tissue macrophages (ATMs), is the key pathogenic link between obesity and metabolic disorders. Oleanolic acid (OA) a natural triterpenoid possessing anti-diabetic anti-inflammation effects, but machinery poorly understood. This study investigated detailed mechanisms OA on in obese mice. C57BL/6J mice were fed with high-fat diet (HFD) for 12 weeks, then daily intragastric administrated vehicle, 25 50 mg/kg 4 weeks....
Introduction China has the largest population of diabetic patients (about 116 million) in world. As a novel model fat index for Chinese people, visceral adiposity (CVAI) was considered reliable indicator to assess dysfunction fat. This study aimed explore dose–response relationship between CVAI and type 2 diabetes mellitus (T2DM) population, considering as continuous/categorical variable. Method Baseline follow-up data were collected from waves 2011 2015, respectively, Health Retirement...
Abstract Chemerin, a secreted protein mainly produced by adipocytes and hepatocytes, plays variety of roles in endocrine or paracrine signaling. As reported human epidemiology, chemerin was correlated with osteoporosis. And the previous vitro study found that knockdown promoted osteogenesis inhibited adipogenesis. However, function bone metabolism underlying mechanism remains unclear. In this study, we uncovered vivo homeostasis. We discovered obese mice, increased serum, while decreased...
Adipocytes and immune cells are vital for the development of adipose tissue. Adipokines secreted by adipocytes regulate adipogenesis body metabolism. Chemerin is one adipokines. However, function mechanism chemerin in tissue not fully illuminated. Compared with wild type (WT) mice, Rarres2−/− mice gained weight significantly increased fat distribution subcutaneous (SAT), rather than visceral (VAT) on high diet (HFD). PPARγ C/EBPα, master regulators adipogenesis, were up-regulated SAT...
Obesity-induced inflammation, characterized by augmented infiltration and altered balance of macrophages, is a critical component systemic insulin resistance. Chemokine-chemokine receptor system plays vital role in the macrophages accumulation. CC-Chemokine Receptor-like 2 (Ccrl2) one receptors Chemerin, which member atypical chemokine (ACKR) family, reported taking part host immune responses inflammation-related conditions. In our study, we found ccrl2 expression significantly elevated...
Abstract Background Periodontitis and orthodontic treatment can lead to inflammatory root resorption (IRR) through an unclear mechanism. Chemerin, a novel chemoattractant protein, is closely associated with inflammation, affects osteoblast osteoclast differentiation, may play role in IRR. We aimed explore possible roles of the chemerin/ChemR23 interaction cementoblast function IRR reveal new therapeutic target. Methods Cementoblast function‐related gene protein expression immortalized murine...
Serotonin (5-HT), a monoaminergic neurotransmitter, involves in the regulation of many physiological functions. In present study, effects 5-hydroxytryptophan (5-HTP), precursor 5-HT, on lipid metabolism and intestinal immune function broiler chickens were investigated chickens.Two hundred broilers divided randomly into two groups fed separately with corn-soybean basal diet (CD) or supplemented 0.2% 5-HTP.The results showed that 5-HTP reduced (P < 0.05) feed intake abdominal fat pad weight....
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of bone fracture, but the mineral density (BMD) typically normal or higher in such patients. Because fracture independent reduced BMD, fragility T2DM may be partially due to poor quality. The mechanisms triggering quality abnormalities are complex, and include accumulation advanced glycation end-products, inflammation, low turnover. Matrix metalloproteinases (MMPs) can hydrolyze matrix. Tissue inhibitors MMPs (TIMPs)...
Automatic detection of pulmonary nodule based on computer tomography (CT) images can significantly improve the diagnosis and treatment lung cancer. However, there is a lack effective interactive tools to record marked results radiologists in real time feed them back algorithm model for iterative optimization. This paper designed developed an online review system supporting assisted nodules CT images. Lung were detected by preset presented doctors, who or corrected with their professional...
Abstract not Available.