A5040026927- Building Energy and Comfort Optimization
- Urban Heat Island Mitigation
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Wind and Air Flow Studies
- Monetary Policy and Economic Impact
- Italy: Economic History and Contemporary Issues
- T-cell and B-cell Immunology
- Economic theories and models
- Economic Theory and Policy
- Transition Metal Oxide Nanomaterials
- Color Science and Applications
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Educational Environments and Student Outcomes
- Noise Effects and Management
- Architecture and Computational Design
- Genetic Syndromes and Imprinting
- Fiscal Policies and Political Economy
- Regional Development and Policy
- Neuroscience and Neural Engineering
- Global Financial Crisis and Policies
- Artificial Intelligence in Healthcare and Education
- Advanced Sensor and Energy Harvesting Materials
University of Pisa
2019-2025
Polytechnic University of Bari
2021-2024
Polytechnic University of Turin
2022-2024
Imperial College Healthcare NHS Trust
2023
University of Oxford
2016-2018
Nuffield Orthopaedic Centre
2016-2018
Imperial College London
2006-2017
Centre for Inflammation Research
2011-2017
Charing Cross Hospital
2015
Hammersmith Hospital
2008-2015
Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers treatment choices are lacking. We did a biopsy-driven trial to compare the response rituximab, etanercept, tocilizumab in biologic-naive with arthritis stratified synovial B cell status.
The objective of this study is to evaluate ChatGPT’s accuracy and reliability in answering complex medical questions related occupational health explore the implications limitations AI medicine. also provides recommendations for future research area informs decision-makers about AI’s impact on healthcare. A group physicians was enlisted create a dataset answers Italian medicine legislation. were divided into two teams, each team member assigned different subject area. ChatGPT used generate...
Membranoproliferative glomerulonephritis (MPGN) type II (dense deposit disease) is an inflammatory renal disease characterized by electron-dense deposits and complement C3 on the glomerular basement membrane. There no effective therapy. We investigated role of C5 activation in a model MPGN that develops spontaneously factor H-deficient mice (Cfh(-/-)). At 12 months there was significant reduction mortality, cellularity, neutrophil numbers, serum creatinine levels Cfh(-/-) deficient C5....
This study was performed to assess the utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies in distinguishing between patients with rheumatoid arthritis (RA) and polyarticular involvement associated chronic hepatitis C virus (HCV) infection. Serum anti-CCP factor (RF) were evaluated 30 RA, 8 HCV infection articular 31 without any joint involvement. In addition, we retrospectively analysed sera collected at time first visit 10 originally presenting symmetric polyarthritis...
FcγRIIB-deficient mice generated in 129 background (FcγRIIB(129)(-/-)) if back-crossed into C57BL/6 exhibit a hyperactive phenotype and develop lethal lupus. Both humans, the Fcγr2b gene is located within genomic interval on chromosome 1 associated with lupus susceptibility. In mice, 129-derived haplotype of this interval, named Sle16, causes loss self-tolerance context B6 genome, hampering analysis specific contribution FcγRIIB deficiency to development FcγRIIB(129)(-/-) mice. Moreover,...
PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression TSPO on activated macrophages, has been widely reported several studies RA as synovial macrophages vivo. However, this premise does not take into account the ubiquitous TSPO. This study aimed investigate major cellular constituents pannus—monocytes, fibroblastlike synoviocytes (FLS cells), CD4-positive (CD4+)...
Large language models, such as ChatGPT-4 and Google Bard, have demonstrated potential in healthcare. This study explores their utility occupational medicine, a field where decisions rely on compliance with specific workplace health safety regulations. A dataset of questions encompassing key topics derived from the Italian Legislative Decree 81/08, which governs safety, was utilized. Responses contextual information (ChatGPT-4+context) Bard were evaluated for accuracy completeness, error...
Extensive evidence indicates that genetic predisposition is a central element in susceptibility to systemic lupus erythematosus both humans and animals. We have previously shown congenic line carrying 129-derived chromosome 1 interval on the C57BL/6 background developed humoral autoimmunity. To further dissect contribution autoimmunity of this 129 interval, we created six subcongenic strains fractions original region analyzed their serological cellular phenotypes. At year age strain between...
This paper proposes an innovative approach to analyse the energy behaviour of complex kinetic shading systems. Although several studies have analysed this topic, many are focused only on certain aspects or simple systems due a lack tools for running reliable simulations study aims develop and validate tool based Python EnergyPlus that can consider continuous nature simulation Simply providing model configurations, algorithm provides as output comparison sheet evaluate performance system. The...
The growing awareness of climate change is constantly moving the attention designers and policymakers from typical current scenarios to future layouts. This new approach introduces a degree uncertainty that should be accounted in building design process. multitude possible suggests considering dynamic system can adapt themselves unpredicted operating conditions. aim this study test flexibility metric analysing behaviour high-performance internal curtain scenarios. first part paper focuses on...
Abstract The complement component C1q is known to play a controversial role in the pathogenesis of systemic lupus erythematosus, but underlying mechanisms remain poorly understood. Intraperitoneal injection pristane induces lupus-like syndrome whose implicates secretion type I IFN by CD11b+ Ly6Chigh inflammatory monocytes TLR7-dependent fashion. was also shown influence IFN-α. In this study, we explored whether deficiency could affect pristane-induced lupus. Surprisingly, C1qa−/− mice...
Among the adaptive solutions, phase change material (PCM) technology is one of most developed, thanks to its capability mitigate effects air temperature fluctuations using thermal energy storage (TES). PCMs belong category passive systems that operate on heat modulation, latent (LHS) can lead a reduction heating ventilation conditioning (HVAC) consumption in traditional buildings and an improvement indoor comfort devoid HVAC systems. The aim this work numerically analyze compare benefits...
The experimental analysis of the main figures merit an innovative electrochromic (EC) prototype, based on low cost gel-polymer electrolytes, is at basis numerical simulation exposed hereafter, aiming assessment energy and visual comfort benefits deriving from building integration smart windows in a multi-storey office building. effectiveness dynamic modulation glazing properties to improve efficiency users' was tested comparing EC with typical law-compliant static commercial system clear...
The pathogenesis of nephrolithiasis in primary hyperparathyroidism (PHPT) remains to be elucidated. latest guidelines suggest parathyroidectomy patients with asymptomatic PHPT hypercalciuria (> 400 mg/d) and increased stone risk profile.The objective this work is evaluate the association urinary factors sporadic its clinical relevance.A total 157 consecutive were evaluated by measurement serum 24-hour parameters kidney ultrasound.Urinary tested univariate analysis as continuous categorical...
Abstract Objective It has been reported that a single dose of human C‐reactive protein (CRP) can prevent and reverse the renal damage in murine models spontaneous lupus, as well rapid‐onset immune complex disease induced accelerated nephrotoxic nephritis (ANTN) model. This study was undertaken to attempt replicate these observations using highly purified fully characterized CRP preparation. Methods (NZB × NZW)F 1 (NZB/NZW) mice were treated with 200‐μg subcutaneous injection or control...
Sulfasalazine has long been used for the treatment of rheumatoid arthritis and is often chosen as a first-line treatment. Here, we report case sulfasalazine-induced autoimmune thrombocytopenia review mechanisms behind drug-induced immune (DITP) approach to its diagnosis management.
The urban heat island (UHI) effect is one of the largest climate-related issues concerning our cities due to localized temperature increase in highly urbanized areas. This paper aims investigate impact UHI mitigation techniques promoting climate resilience, by reducing air temperatures and cooling energy consumption buildings. To this end, four solutions regarding building envelope—green roofs, green walls, cool walls—were investigated for city Bari Southern Italy compared with current...