A5066878095- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Skin Protection and Aging
- melanin and skin pigmentation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Melanoma and MAPK Pathways
- Proteoglycans and glycosaminoglycans research
- CAR-T cell therapy research
- Chromatin Remodeling and Cancer
- Animal Virus Infections Studies
- Macrophage Migration Inhibitory Factor
- Fibroblast Growth Factor Research
First Affiliated Hospital of Zhengzhou University
2025
University of California, Berkeley
2024
Guangzhou Institute of Dermatology
2023
National Cancer Institute
1999-2022
National Institutes of Health
1998-2022
Center for Cancer Research
2022
National Heart Lung and Blood Institute
1999
National Institute on Aging
1998
Abstract Background Tumor immune escape is a pivotal gateway for esophageal squamous cell carcinoma (ESCC) development. Immune checkpoint-blocking therapies, represented by programmed death receptor-1/ligand 1 (PD-1/PD-L1) inhibitors, have achieved remarkable breakthroughs in ESCC treatment. However, not all patients with receive satisfactory clinical benefit. Therefore, identifying novel biomarkers predicting the efficacy of immunotherapy great importance. Methods CircNF1 was screened from...
Abstract Altered lipid metabolism is a common hallmark of various cancers, including intrahepatic cholangiocarcinoma (ICC), highly lethal carcinoma that lacks effective treatment options. To elucidate the changes in ICC, we coupled expression firefly luciferase gene (FFL) to AKT1 (AKT-FFL) via an IRES linker, and then hydrodynamically injected mice with AKT-FFL Notch1 intracellular cytoplasmic domain (NICD) establish luciferase-positive ICC model. This model not only enabled us monitor...
As a complex of natural plant compounds, tanshinone is renowned for its remarkable antioxidant properties. However, the potential impact on melanocyte pigmentation regulation has yet to be elucidated. This study aimed explore protective effects I (T-I) and dihydrotanshinone (DHT) melanogenesis by modulating nuclear factor E2-related 2 (Nrf2) signaling defenses in human epidermal (HEM) cells.
The development of cancer therapeutics has evolved from general targets with radiation and chemotherapy shifted toward treatments a more specific mechanism action such as small molecule kinase inhibitors, monoclonal antibodies against tumor antigens, or checkpoint inhibitors. Recently, oncolytic viruses (OVs) have come to the forefront viable option for immunotherapy, especially "cold" tumors, which are known inhabit an immunologically suppressive microenvironment. Desired characteristics...
<p>Gene expression levels of FATP5 were measured using qPCR in 5 normal livers (NL), 33 ICC, and related surrounding (SL).</p>
<p>Gene expression levels of Fatp5, and Fasn were measured using qPCR in AAV-shSCR AAV-shFatp5 ICC tumors.</p>
<div>Abstract<p>Altered lipid metabolism is a common hallmark of various cancers, including intrahepatic cholangiocarcinoma (ICC), highly lethal carcinoma that lacks effective treatment options. To elucidate the changes in ICC, we coupled expression firefly luciferase gene (FFL) to <i>AKT1</i> (<i>AKT-FFL</i>) via an IRES linker, and then hydrodynamically injected mice with AKT-FFL <i>Notch1</i> intracellular cytoplasmic domain...
<div>Abstract<p>Altered lipid metabolism is a common hallmark of various cancers, including intrahepatic cholangiocarcinoma (ICC), highly lethal carcinoma that lacks effective treatment options. To elucidate the changes in ICC, we coupled expression firefly luciferase gene (FFL) to <i>AKT1</i> (<i>AKT-FFL</i>) via an IRES linker, and then hydrodynamically injected mice with AKT-FFL <i>Notch1</i> intracellular cytoplasmic domain...
<p>Gene expression levels of FATP5 were measured using qPCR in 5 normal livers (NL), 33 ICC, and related surrounding (SL).</p>
<p>Gene expression levels of Fatp5, and Fasn were measured using qPCR in AAV-shSCR AAV-shFatp5 ICC tumors.</p>