A5088445170- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Gout, Hyperuricemia, Uric Acid
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- Potassium and Related Disorders
- Electrolyte and hormonal disorders
Third Affiliated Hospital of Southern Medical University
2022-2025
Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are common in patients with chronic kidney disease (CKD), but uniform thresholds derived from the general population may not accurately predict heart failure (HF) risk across stages of function. This study aimed to determine whether specific function categories improve HF prediction CKD. retrospective cohort used data China Renal Data System, including 18 261 CKD without prior HF. Kidney function-specific for NT-proBNP...
Acute kidney injury (AKI) is in high prevalence the world. However, therapeutic strategies for AKI are still mystery. Studies have shown to improve autophagy and lysosomal function could inhibit AKI. But their modulators need be explored detail. Annexin A2 (ANXA2) a phospholipid-binding protein involving organelle membrane integrity function, suggesting its important role lysosome homeostasis. It implicates ANXA2 potentially protects against this has not been elucidated. Herein, we found...
Cardiorenal syndrome highlights the bidirectional relationship between kidney and heart dysfunction. N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is gold standard biomarker in failure (HF), may be an important for chronic disease (CKD) progression. However, NT-proBNP negatively related with estimated glomerular filtration rate (eGFR). In this study, we investigated association of NT-proBNP, eGFR, progression CKD patients without HF.
Abstract Background and Aims Interleukin-6 (IL-6) is a key mediators of inflammation has been linked to the severity mortality COVID-19-Omicron in general population. With higher rates observed maintenance hemodialysis (MHD) patients infected with COVID-19-Omicron, study aimed examine correlation between IL-6 levels this patient population indentify optimal level for predicting risk death. Method The retrospective observational was conducted MHD diagnosed infection December 01, 2022 January...
Abstract Background and Aims It is well known that serum uric acid (SUA) plays an important role both in patients with without chronic kidney disease (CKD). However, the effect of SUA on renal outcomes CKD patients, especially asymptomatic hyperuricemia, remains controversial. Therefore, our study explores relationship between adverse events early (stage 1-3) a real-world setting. Method This multi-center analyzed data from Chinese Renal Data System (CRDS). Eligible (eGFR) (estimated...
Abstract Aim Acute kidney injury (AKI) is becoming a heavy health burden worldwide. There are no effective therapeutic strategies nowadays. Recent studies showed that autophagy and lysosome stabilization could inhibit tubular cell apoptosis, protect against AKI. Annexin A2 (ANXA2), calcium-regulated phospholipid-binding protein, was found to be highly involved in autophagy. However, its role AKI has not been elucidated. Results We ANXA2 increased renal cells cisplatin-treated mice, the urine...