A5100615259- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Click Chemistry and Applications
- HIV Research and Treatment
- Virology and Viral Diseases
- Advanced biosensing and bioanalysis techniques
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Chemical Synthesis and Analysis
- Data-Driven Disease Surveillance
- Inflammasome and immune disorders
- interferon and immune responses
- Plant biochemistry and biosynthesis
- Organoselenium and organotellurium chemistry
- Natural product bioactivities and synthesis
- HIV/AIDS drug development and treatment
- Sulfur-Based Synthesis Techniques
Guangzhou University of Chinese Medicine
2023-2024
Zhejiang University of Technology
2022-2023
Dali University
2022
Shanghai Public Health Clinical Center
2017-2020
Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently available prevent treat ZIKV infection. Here we report that synthetic peptide derived from the stem region of envelope protein, designated Z2, potently inhibits infection other flaviviruses in vitro. We show Z2 interacts surface protein disrupts integrity viral membrane. can penetrate...
Aberrant activity of NLRP3 has been shown associations with severe diseases. Palmitoylation is a kind protein post-translational modification, which to regulate cancer development and the innate immune system. Here, we showed that palmitoylated at Cys419 palmitoyltransferase ZDHHC17 predominant enzyme mediates palmitoylation promotes activation by interacting facilitating NIMA-related kinase 7 (NEK7)-NLRP3 interactions. Blockade inhibitor, 2-bromopalmitate, effectively inhibited in vitro....
Abstract A successful DNA‐encoded library (DEL) will consist of diverse skeletons and cover chemical space as comprehensive possible to fully realize its potential in drug discovery biology. However, the lack versatile on‐DNA arylation methods for phenols that are less nucleophilic reactive poses a great hurdle DEL include diaryl ether, privileged chemotype pharmaceuticals natural products. This work describes use “substrate activation” approach address DNA‐conjugated phenols. Diaryliodonium...
Zika virus (ZIKV) is an RNA-enveloped that belongs to the Flavivirus genus, and ZIKV infections potentially induce severe neurodegenerative diseases impair male fertility. Palmitoylation important post-translational modification of proteins mediated by a series DHHC-palmitoyl transferases, which are implicated in various biological processes viral infections. However, it remains be investigated whether palmitoylation regulates In this study, we initially observed inhibition 2-bromopalmitate...
Zika virus (ZIKV) was a re-emerging arbovirus associated with Guillain-Barré Syndrome in adult and congenital syndrome fetus infant. Although ZIKV mainly transmitted by mosquito bites, many sexual transmission cases have been reported since the outbreak 2015. can persist testis semen for long time, causing testicular tissue damage reducing sperm quality. However, no drug has approved prevention or treatment of infection, especially infection male tissue. Previously peptide Z2 could...
HIV-associated morbidity and mortality have markedly declined because of combinational antiretroviral therapy, but HIV readily mutates to develop drug resistance. Developing antivirals against previously undefined targets is essential treat existing drug-resistant strains. Some peptides derived from HIV-1 envelope glycoprotein (Env, gp120-gp41) been shown be effective in inhibiting infection. Therefore, we screened a peptide library Env identified the cytoplasmic region, designated F9170,...
Objective To evaluate the reporting quality of notifiable communicable diseases in hospitals at all levels China, and provide evidence for further improvement quality. Methods A total 116 9 provinces were investigated, which selected through multi-stage stratified cluster sampling 31 provinces, autonomous regions, municipalities Xinjiang Production Construction Corps. Results 1952 outpatient inpatient records analyzed, 1867 reported direct network system. The overall rate was 95.65%....
Selen ist ein vielseitiges Element in der medizinischen Chemie. In ihrem Forschungsartikel (e202206516) stellen Hongtao Xu, Fei Ma, Guang Yang, Wei Hou et al. eine bioinspirierte SeClick-Chemie zwischen Indol und Benzoselenazol vor, die Parallelsynthese von Indol-Selenid-Bibliotheken selenhaltigen DNA-kodierten Bibliotheken (SeDELs) auf modulare Weise eingesetzt werden kann so Entwicklung Selen-Chemie naher Zukunft fördern wird.