A5103282638- Robotics and Sensor-Based Localization
- Cancer-related molecular mechanisms research
- Advanced Vision and Imaging
- Metallurgy and Material Forming
- Ubiquitin and proteasome pathways
- HIV Research and Treatment
- Gear and Bearing Dynamics Analysis
- Advanced Neural Network Applications
- Dermatological and COVID-19 studies
- Digital Image Processing Techniques
- Security and Verification in Computing
- Soil, Finite Element Methods
- Antibiotic Resistance in Bacteria
- Rangeland and Wildlife Management
- RNA modifications and cancer
- Medical Image Segmentation Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Genetics, Aging, and Longevity in Model Organisms
- Robotic Path Planning Algorithms
- interferon and immune responses
- Arctic and Antarctic ice dynamics
- Machine Learning in Materials Science
- BIM and Construction Integration
- Computational Drug Discovery Methods
- Numerical methods in engineering
Wuhan University
2017-2023
Huazhong University of Science and Technology
2023
Renmin Hospital of Wuhan University
2022
Beijing Jingshida Electromechanical Equipment Research Institute
2021
Beihang University
2015
Institute of Environmental Protection
2014
Nanjing University of Aeronautics and Astronautics
2011
Southwest University of Science and Technology
2008
Hunan University
2007
The immune system is not only required for preventing threats exerted by pathogens but also essential developing tolerance to avoid tissue damage. This study identifies a distinct mechanism which MYSM1 suppresses innate immunity and autoimmunity. expression of induced upon DNA virus infection intracellular stimulation. subsequently interacts with STING cleaves K63-linked ubiquitination suppress cGAS-STING signaling. Notably, Mysm1-deficient mice exhibit hyper-inflammatory response, acute...
Abstract Aging is a universal feature of life that major focus scientific research and risk factor in many diseases. A comprehensive understanding the cellular molecular mechanisms aging are critical to prevention diseases associated with process. Here, it shown MYSM1 key suppressor aging‐related pathologies. functionally represses senescence process human mice primary cells organs. mechanistically attenuates by promoting DNA repair processes. Remarkably, deficiency facilitates reduces...
Global motion estimation (GME) is a key technology in unmanned aerial vehicle remote sensing (UAVRS). However, when UAV’s and behavior change significantly or the image information not rich, traditional image-based methods for GME often perform poorly. Introducing bottom metadata can improve precision large-scale condition reduce dependence on unreliable information. divided into coarse residual through coordinate transformation based study hypotheses. In GME, an auxiliary built to convert...
Abstract Long noncoding RNAs (lncRNAs) play important roles in regulating HIV-1 infection and virus-host interactions. However, it is unclear whether how ART alters lncRNAs HIV-infected patients. In the present study, we investigated changes of PBMCs from patients pre- post-ART. We identified a total 974 whose expression was restored to normal levels after ART. Cis-acting analysis showed that six have cis-regulated target genes, among which RP11-290F5.1 interferon regulatory factor 2 (IRF2)...
The ubiquitin-proteasome system (UPS) is essential for the degradation of damaged proteins, which takes place in proteasome. Upon activation by cytokines, catalytic subunits proteasome are replaced distinct isoforms resulting formation an immunoproteasome (iProteasome). iProteasome generates peptides used major histocompatibility complex class I (MHC-I) antigen presentation and immune responses. HIV-1 causative agent AIDS, HIV-1-specific cytotoxic T lymphocytes (CTLs) provide responses...
In TrustZone architecture, the Trusted Application (TA) in secure world does not certify identity of Client Applications (CA) normal that request data access, which represents a user leakage risk. This paper proposes private protection mechanism to avoid such risks. We add corresponding modules both and authenticate CA prevent illegal access data. Then we analyze system security, perform validity performance tests. The results show this method can effective recognition control protect...
Involute helical gears mesh based on the intersections of involute helicoids. However, spiral involutes tooth surface do not participate in meshing directly. A new type gear drive, is proposed that works contact involutes. The generation profile introduced detail. Through relative-stagnation method, prove to have conjugation characteristics. To testify whether transmission ratio cylindrical constant, simulation implemented commercial codes ADAMS solid models a pair gears. computed results...
Robot self-localization is one of the key problems to improve robot autonomous ability. In order increase localization precision mobile robot, a algorithm based on odometry, single vision and laser radar proposed. First, odometry estimated robotpsilas pose at every sampling time. At same time, angles between any two landmarks were measured by means camera. Laser obtained information that indicating distance angle landmarks. Then, data provided fused together an extended Kalman filter (EKF)...
There is a growing interest in the role that LLMs play chemistry which lead to an increased focus on development of benchmarks tailored chemical domains assess performance across spectrum tasks varying type and complexity. However, existing this domain fail adequately meet specific requirements research professionals. To end, we propose \textbf{\textit{ChemEval}}, provides comprehensive assessment capabilities wide range tasks. Specifically, ChemEval identified 4 crucial progressive levels...
This paper focuses on addressing the problem of 6DoF object pose estimation with a known 3D model from single RGB image. Some recent works have shown that structure information is effective for but they do not make full use. We propose SE-UF-PVNet, more explicit, flexible, and powerful framework to introduce information. construct keypoint graph in coordinate system, Graph Convolution Network module extract features graph, concatenate them extracted images by keypoints regressing network at...
Abstract Background: Many studies have shown that long noncoding RNAs (lncRNAs) derived from the host and human immunodeficiency virus (HIV) itself play important roles in virus-host interactions viral pathogenesis. To identify potential key lncRNAs regulation of HIV pathogenesis, transcriptome analysis peripheral blood mononuclear cells (PBMCs), which were 6 HIV/acquired syndrome (AIDS) subjects pre-HAART post-HAART with effective control plasma viremia (<20 RNA copies/ml) healthy...
Abstract Proteasome is major protein degradation machinery and plays essential roles in diverse biological functions. Upon cytokine inductions, proteasome subunits β1, β2, β5 are replaced by β1i/LMP2, β2i/MECL-1, β5i/LMP7, leading to the formation of immunoproteasome. Immunoproteasome-degraded products loaded onto histocompatibility complex class I (MHC-I) regulate immune responses induce cytotoxic-T-lymphocytes (CTLs). Human immunodeficiency virus type 1 (HIV-1) causal agent acquired...