A5091318145- Immunotherapy and Immune Responses
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Digital Innovation in Industries
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cervical Cancer and HPV Research
- Ear Surgery and Otitis Media
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Privacy, Security, and Data Protection
- Digital Marketing and Social Media
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
University of Alberta
2025
MSB Medical School Berlin
2022-2024
Charité - Universitätsmedizin Berlin
2014-2024
Humboldt-Universität zu Berlin
2017-2024
Freie Universität Berlin
1998-2024
Heidelberg University
2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2021
HNO-Praxis
2021
Franklin University
2010-2020
Goethe University Frankfurt
2005-2013
Initiation, growth, recurrence, and metastasis of head neck squamous cell carcinomas (HNSCC) have been related to the behavior cancer stem cells (CSC) that can be identified by their aldehyde-dehydrogenase-isoform-1 (ALDH1) activity. We quantified enriched ALDH1+ within HNSCC lines subsequently characterized phenotypical functional properties like invasion capacity epithelial-mesenchymal transition (EMT). Spheroid culture CSC from five up 5-fold. In spheroid-derived (SDC) parental...
Patients with squamous cell carcinoma of the head and neck (SCCHN) have depressed antitumour immunity. The presence CD4+CD25+ (Treg) cells in these patients might be, part, responsible for downregulation immune responses. To evaluate frequency characteristics Treg peripheral circulation SCCHN, we used multicolour flow cytometry. Expression CCR7, CD62L, zeta chain Annexin V binding to non-Treg CD4+ lymphocyte populations were evaluated. confirmed be Foxp3+ GITR+. was significantly elevated...
Many environmental, host, and microbial characteristics have been recognized as risk factors for dissemination of extrapulmonary tuberculosis (EPTB). However, there are few population-based studies investigating the association between primary sites (TB) infection mortality during TB treatment. De-identified surveillance data confirmed patients reported from 2009 to 2015 in Texas, USA, were analyzed. Regression analyses used determine EPTB, well its subsite distribution mortality. We...
Abstract Human papillomavirus (HPV)–associated squamous cell carcinoma of the head and neck (SCCHN) seems to be a suitable target for cancer vaccination. HPV-encoded oncogenic proteins, such as E7, are promising tumor-specific antigens obligatory tumor growth. Because few immunologic studies have analyzed endogenous HPV-specific immune response in this subset SCCHN patients, we studied T-cell frequencies against HPV-16 E711-20 or E786-93 tumor-bearing, human leukocyte antigen (HLA)-A*0201+...
Abstract Background Tumor‐derived membranous vesicles (MV) isolated from sera of the patients with squamous cell carcinomas head and neck (HNSCC) induce apoptosis activated CD8 + T cells. We tested if MV molecular profile activity correlate disease progression. Methods Jurkat cells were incubated MAGE 3/6 , FasL MHC class I 60 HNSCC 25 normal controls by exclusion chromatography ultracentrifugation. Z‐VAD‐FITC binding to was measured correlated clinical data. Results patients' sera, but not...
Participation of people is the most important factor in providing high quality service participatory sensing applications. In this paper, we study monetary incentives order to stimulate user's participation, especially applications that rely on real-time data. Providing such hard because provider cannot determine price at which each user would be willing sell his own Introducing traditional reverse auction mechanisms allow reveal value, but they do not take under consideration fact data are...
The chemotherapeutic agent cisplatin typically induces apoptosis by inhibiting the cell cycle. Cancer Stem Cells (CSCs), which are a proliferative quiescent and slowly-cycling population, less sensitive therefore frequently spared from toxic effects. Thus, it remains priority to increase sensitivity of CSCs cisplatin-based chemotherapy, or specifically target improve therapeutic outcome in breast cancer. Disulfiram (DSF) is drug used clinically for alcoholism treatment that has displayed...
Disulfiram (DSF) is a drug used for treatment of alcoholism that has also displayed promising anti-cancer activity. It unfolds its effects by inhibiting the enzyme activity aldehyde dehydrogenase (ALDH) isoforms.MTT assay, spheroid formation, clonogenicity qRT-PCR, and ALDH analysis were performed using ovarian cancer cell lines IGROV1, SKOV3 SKOV3IP1. Cell cycle analyses measurement intracellular reactive oxygen species (ROS) carried out flow cytometry. ALDH+ ALDH- cells isolated FACS...
Abstract “How strong is this Lewis acid?” a question researchers often approach by calculating its fluoride ion affinity (FIA) with quantum chemistry. Here, we present FIA49k, an extensive FIA dataset 48,986 data points calculated at the RI‐DSD‐BLYP‐D3(BJ)/def2‐QZVPP//PBEh‐3c level of theory, including 13 different p ‐block atoms as accepting site. The FIA49k was used to train FIA‐GNN, two message‐passing graph neural networks, which predict gas and solution phase values molecules excluded...
Patient-derived xenograft (PDX) models have shown to reflect original patient tumors better than any other preclinical model. We embarked in a study establishing large panel of head and neck squamous cell carcinomas PDX for biomarker analysis evaluation established novel compounds. Out 115 transplanted specimens 52 were which 29 characterized response docetaxel, cetuximab, methotrexate, carboplatin, 5-fluorouracil everolimus. Further, subjected sequencing gene expression profiling selected...
Therapeutic vaccination of tumor patients with cytokine gene-transfected cells leads to regression in animal models but has so far not resulted significant clinical benefit. We and others demonstrated that transfected mediate overexpression a gene activate immunologic effector for an improved proliferation rate significantly higher antitumoral cytotoxic activity. Here, we performed pilot study therapeutic metastatic disease. Autologous were simultaneously novel minimalistic, immunogenically...