A5074552329- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Voice and Speech Disorders
- Head and Neck Surgical Oncology
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Airway Management and Intubation Techniques
- Cancer-related gene regulation
- Dysphagia Assessment and Management
- Viral-associated cancers and disorders
- Obstructive Sleep Apnea Research
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Ear and Head Tumors
- Vascular Tumors and Angiosarcomas
- Tumors and Oncological Cases
- Antimicrobial Peptides and Activities
- Polyomavirus and related diseases
- Trauma Management and Diagnosis
- Immune Response and Inflammation
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
Medizinische Hochschule Brandenburg Theodor Fontane
2023-2025
Brandenburg University of Technology Cottbus-Senftenberg
2023-2025
University of Potsdam
2023-2025
Charité - Universitätsmedizin Berlin
2015-2024
Humboldt-Universität zu Berlin
2017-2024
Freie Universität Berlin
2017-2024
MSB Medical School Berlin
2011-2021
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021
Franklin University
2008-2018
Unfallkrankenhaus Berlin
2011-2015
Diffuse large B-cell lymphoma (DLBCL) is the most frequent aggressive lymphoma, with a great demand for novel treatments relapsing and refractory disease. Constitutive activation of phosphatidyl-inositol-3-kinase (PI3K)/Akt/mammalian target rapamycin (mTOR) signaling pathway often detected in this lymphoma. Inhibition cascade pan-class I PI3K inhibitor NVP-BKM120 decreased cell proliferation increased apoptotic death. DLBCL was further if NVP-BKM120-induced autophagy blocked. Treatment...
Abstract Objective/Hypothesis: Evidence‐based guidelines for the selection of appropriately sized ventilation tubes as well their placement do not exist, although iatrogenic injuries to trachea and larynx following endotracheal intubation are infrequent. Our objective was provide recommendations based on anatomic criteria. Study Design: Prospective cross‐sectional study at a tertiary care hospital. Methods: From January 2010 June all patients more than 16 years who underwent computer...
Decreasing numbers of tonsillectomies (TE) and an increasing frequency oropharyngeal squamous cell carcinoma (OPSCC) is a well-known finding in western societies. A retrospective cohort study was performed to investigate the association between history TE development OPSCC. This included all OPSCC patients who were treated 2004 2023 at Department Otorhinolaryngology University Medical Centre Ruppin Brandenburg Germany. Digital patient charts used collect information. Of 320 with OPSCC, 19...
Postoperative vertigo is a well-known complication after cochlear implantation. The aim of the study was to investigate whether electrical stimulation auditory structures via implant electrodes can affect vestibular system and induce vertigo.In first group, 114 patients were surveyed retrospectively questionnaires evaluate occurrence frequency sound-induced In second group 26 patients, effects on studied prospectively.In without any preoperative (n = 104), 20 (18%) reported vertigo, which...
ABSTRACT Background In the 8th edition of TNM classification, extracapsular spread (ECS) became a factor in classifying UICC stage oropharyngeal carcinomas (OPSCC). We aimed to find genetic markers for ECS and identify differences between HPV/p16‐positive HPV/p16‐negative cases. Methods performed targeted next‐generation sequencing on 99 samples operable OPSCC retrospective analysis clinical data. Results included 55 44 patients. found significant difference both groups, particularly TP53...
Noise exposure leads to dramatic physiological and anatomical changes within the central auditory pathway in addition well-known cochlear damage. Our group previously described a significant loss of neurons different structures upon acoustic overstimulation. The aim present study was investigate if declined neuronal cell density is caused by apoptotic mechanisms. Mice were noise-exposed (3 h, 5–20 kHz) at 115 dB SPL under anesthesia investigated immediately after, 6 24 or 7 days after...
The round window membrane (RWM) approach is designed to provide an atraumatic scala tympani implantation with the goal of enhanced preservation hearing and vestibular receptor function. Perimodiolar electrode designs offer advantages in electrophysiologic testing. However, perimodiolar arrays have only been investigated insertion trials using temporal bone material. aim present study was evaluate placement a clinical trial.The prospective nonrandomized included 27 patients (October 2010...
Objective Patients presenting with a cervical mass are common for head and neck specialists present diagnostic challenge against the backdrop of wide variety etiologies. The objective study was to evaluate significance in supraclavicular fossa etiology, procedure, therapy. Study Design Individual retrospective cohort study. Methods We reviewed data 211 consecutive cases (116 male, 95 female) excisional biopsy or tumor removal mass. Results In 202 cases, taken from lymph node. 182 biopsies,...
Abstract Background Liver transplant recipients have an increased risk of developing de novo malignancies. Methods We conducted a prospective evaluation clinicopathological data and predictors for overall survival (OS) in patients with head neck squamous cell carcinoma (HNSCC) after liver transplantation (1988 to 2010). Results Thirty‐three 2040 who underwent (1.6%) developed HNSCC. The incidence HNSCC end‐stage alcoholic disease (26) was 5%. After median follow‐up 9 years, 1‐year, 3‐year,...
This study analyzed the expression of p16 in a large cohort patients suffering from oral squamous cell carcinoma (OSCC) who received initial surgical therapy order to evaluate prognostic significance and analyze its value as surrogate marker determine human papilloma virus (HPV) status.Immunohistochemical staining was performed on tissue microarrays. Different levels (>25%; >50%; ≥70%) with moderate strong intensity were correlated clinical outcome. HPV DNA by polymerase chain reaction...
Background/Aim: Parotid gland tumors are mostly solitary of the salivary tissue. There is limited evidence about multifocal tumor growth parotid gland. Patients and Methods: We reviewed medical records 796 consecutive parotidectomies in 758 patients over last 40 years our department, investigated incidence histological type synchronous metachronous tumors. Multifocal recurrent hybrid were excluded. Results: identified 93 (13%) with multiple lesions. Their mean age was 63 (range=15-93) years....
Postintubation tracheal ruptures (PTR) are rare but cause severe complications. Our objective was to investigate the pattern of injury resulting from cuff inflation tube, study two main factors responsible for PTR (cuff overinsufflation and inapplicable tube sizes), explain context, why small women particularly susceptible PTR.Experimental performed on 28 fresh human laryngotracheal specimens (16 males, 12 females) within 24 hours post autopsy. Artificial ventilation simulated by using an...
Background: Patients presenting with a cystic lateral neck lesion may present diagnostic challenges against backdrop of varied non-malignant and malignant etiologies. Patients: A total 133 consecutive cases who underwent tumor removal were evaluated for etiology procedure in order to develop an algorithm therapeutic efficiency. Results: In 92 cases, was diagnosed. 41 lymphadenopathy found. malignancy, males (p=0.001) the elderly affected more frequently. Primary tumors discovered by...
After stapes surgery, patients with mixed or moderate hearing loss have limited possibilities for improvement. We are reporting on a patient who underwent stapedotomy bilaterally 20 years ago and had sensorineural loss. Recurrent otitis externa prevented the use of aids. This was treated Vibrant Soundbridge (Med-El, Innsbruck, Austria) successively. The Schuknecht piston prostheses remained in situ. Floating Mass Transducer (FMT; Med-El) coupled to round window (RW) provided good acoustic...
Abstract Purpose The aim was to analyze the incidence and survival of patients living with HIV (PLWH) head neck squamous cell carcinoma (HNSCC) compare a control group HIV-negative HNSCC patients. Methods Clinicopathological data predictors for overall (OS) disease-free (DFS) were investigated (2009–2019). Results 50 5151 (0.97%) PLWH, 76% smokers. Age ≤ 60 years, HIV-PCR copies, CD4 cells 200/mm 3 , cART treatment, T UICC classification, oral cavity nasal/paranasal sinuses, therapy...