A5083483896- Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- CAR-T cell therapy research
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
Charité - Universitätsmedizin Berlin
2019-2025
Humboldt-Universität zu Berlin
2024-2025
Freie Universität Berlin
2024-2025
German Cancer Society
2024
Deutschen Konsortium für Translationale Krebsforschung
2024
German Cancer Research Center
2024
Heidelberg University
2024
ABSTRACT Background In the 8th edition of TNM classification, extracapsular spread (ECS) became a factor in classifying UICC stage oropharyngeal carcinomas (OPSCC). We aimed to find genetic markers for ECS and identify differences between HPV/p16‐positive HPV/p16‐negative cases. Methods performed targeted next‐generation sequencing on 99 samples operable OPSCC retrospective analysis clinical data. Results included 55 44 patients. found significant difference both groups, particularly TP53...
Mucosa-associated lymphoid tissue (MALT) lymphomas are slow-growing B-cell mainly diagnosed in the stomach and termed gastric MALT lymphoma (G-MALT). Despite histological evaluation, immunostaining, additional clonality analysis by fragment analysis, a clear-cut diagnosis is not feasible all cases, especially for clinical follow-up of patients after treatment. We examined clonally rearranged immunoglobulin heavy- light-chain gene sequences 36 genomic DNA samples from six different obtained...
Aggressive B-cell lymphoma encompasses Burkitt (BL), diffuse large (DLBCL), and, as per the 2016 WHO classification, high-grade (HGBL) not otherwise specified (NOS) and HGBL double/triple hit (DH/TH). However, diagnostic distinction of from BL DLBCL is difficult by means histology/immunostaining in a substantial number patients. This study aimed to improve subtyping identification molecular features aggressive lymphomas, with specific focus on HGBL. To this end, we performed comprehensive...
Under the 8th edition of TNM classification, in addition to HPV status, extracapsular growth (ECS) plays an important role classification UICC stage oropharyngeal carcinomas. Both factors could be associated with different mutation profiles. Therefore, aim this study was identify genetic markers for ECS and differences between HPV-positive HPV-negative patients. We sequenced 99 samples operable carcinomas using targeted next-generation sequencing determined status. Clinical data including...
Seit der 8. Auflage TNM-Klassifikation spielt neben dem HPV-Status auch das extrakapsuläre Wachstum (ECS) eine wichtige Rolle bei Einteilung des UICC-Stadiums Oropharynxkarzinomen. Beide könnten mit unterschiedlichen Mutationsprofilen verbunden sein. Unser Ziel war daher einerseits, genetische Marker für ECS herauszufinden, und andererseits Unterschiede je nach zu identifizieren. Wir unterzogen 99 Proben operabler Oropharynxkarzinome einer gezielten Next-Generation-Sequenzierung bestimmten...