A5101747145- Algal biology and biofuel production
- Hedgehog Signaling Pathway Studies
- Kruppel-like factors research
- MicroRNA in disease regulation
- Phytochemical compounds biological activities
- Bacterial biofilms and quorum sensing
- Bioinformatics and Genomic Networks
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- RNA and protein synthesis mechanisms
- Pharmacological Effects and Assays
- Photosynthetic Processes and Mechanisms
- Reproductive Biology and Fertility
- Insect and Pesticide Research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Marine and coastal ecosystems
- Epigenetics and DNA Methylation
- Tumors and Oncological Cases
- Psoriasis: Treatment and Pathogenesis
- Hereditary Neurological Disorders
- Tea Polyphenols and Effects
- Fermentation and Sensory Analysis
Zunyi Medical University
2016-2025
Union Hospital
2013-2024
Huazhong University of Science and Technology
2013-2024
Hainan Medical University
2024
Guangzhou University of Chinese Medicine
2023
Guangdong Provincial People's Hospital
2023
Central South University
2023
Xiangya Hospital Central South University
2023
Shihezi University
2018-2021
Xinxiang Medical University
2021
Abstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies revealed ncRNA-derived micropeptides exhibit regulatory functions in the development many tumours. Although some these inhibit tumour growth, others promote it. Understanding role ncRNA-encoded cancer poses new challenges for research, but also...
Aspongopus chinensis Dallas is used as a traditional Chinese medicine. In China, clinical evidence suggests that it has anticancer activity. However, the active components are not fully elucidated. present study, we purified an component (named CHP) from A. chinensis. To gain comprehensive insight into protein components, shotgun proteomic analysis was conducted. The band cut sodium dodecyl sulphate-polyacrylamide gel electrophoresis and digested with trypsin to generate peptide mixture....
To get a tumor-targeted contrast agent for imaging guide resection of tumors, we designed novel fluorescent probe based on the heptamethine cyanine core, Cy7-MO, which has excellent water solubility and near-infrared photophysical lysosomal targeting properties. The chemical structure Cy7-MO was characterized by nuclear magnetic resonance spectroscopy high-resolution mass spectrometry. toxicity evaluated cell counting kit-8. Then, cellular-level study conducted to evaluate suborganelle...
Melioidosis is a zoonotic disease, with its outbreaks being rare and indicative of an unusual concurrence extreme climate natural environmental factors. An outbreak melioidosis cases emerged in Hainan following Typhoon "Dianmu" from October to December 2021, presenting opportunity identify the sources infection for these due nature as well-defined point-source cluster. To investigate relationship between occurrence environment, we extracted entire genome 25 clinical strains conducted MLST...
The insecticide acetamiprid is used to control noxious agricultural pests. However, it can cause mammalian toxicity. We evaluated the reproductive toxicity of in adult male Sprague Dawley rats. Rats were given oral alone or with vitamin E for 35 days. Rat plasma testosterone concentration and sperm quality decreased significantly as levels luteinizing hormone (LH) increased after exposure. At same time, malondialdehyde nitric oxide (NO) Leydig cells. Further analysis showed that reduced...
With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one most efficient therapeutic strategies. Our study aimed evaluate potential for synergy combined CHIR-090, a potent LpxC inhibitor, against vitro vivoPseudomonas aeruginosa biofilms. Four P. isolates various susceptibilities were chosen evaluation. The tested exhibited MIC values ranging from 1 64...
ABSTRACT Background Haploinsufficiency is widely accepted as the pathogenic mechanism of spastic paraplegia type 4 (SPG4). However, there are some cases that cannot be explained by reduced function spastin protein encoded SPAST . Objectives To identify causative gene autosomal dominant hereditary in three large Chinese families and explore pathological a variant. Methods Three with total 247 individuals (67 patients) were investigated, whom 59 members recruited to study. Genetic testing was...
Natural products from insects can be potent sources for developing a variety of pharmaceutical products. Aspongopus chinensis Dallas has been used as traditional Chinese medicine and there are several clinical evidences to support its anticancer activity. However, the active ingredients present in A. remain unidentified. In study, we investigated effects methanol extract (AME). Gas chromatography mass spectrometry was analyse chemical composition AME. The cell viability MDA-MB-453 HCC-1937...
Chlorella has become an important raw material for biodiesel production in recent years, and sp. TLD6B, a species with high lipid concentrations salt drought tolerance, been cultivated on large scale. To explore the accumulation of TLD6B its relationship to external NaCl concentrations, we performed physiological measurements genome-wide gene expression profiling under different levels stress. was able tolerate stress (0.8 M addition). Lipid initially increased then decreased as were highest...
Aspongopus chinensis Dallas is a traditional Chinese medicinal insect with several anticancer properties can inhibit cancer cell growth, by inhibiting division, autophagy and cycle. However, the precise therapeutics effects mechanisms of this on liver are still unknown. This study examined inhibitory influence A. proliferation hepatocellular carcinoma (HCC) cells explore underlying mechanism using high-throughput sequencing. The results showed that substantially reduced viability Hep G2...
Apoptosis plays an important role in both carcinogenesis and cancer treatment. Drugs or treatment strategies that can restore the apoptotic signaling pathways have potential to eliminate cancer. Caspase 8 (CASP8) a vital propagation of enzymatic cascade results cell apoptosis.In this study, authors investigated inhibitory effects HIV Gag virus-like particles (VLPs) are incorporated with active CASP8 (Gag-CASP8-VLPs) on growth breast Their data shown Gag-CASP8-VLPs, pseudotyped by stomatitis...